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Lithostathine

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The proteinaceous component of the pancreatic stone in patients with PANCREATITIS.

Also Known As:

Lithostatin; Pancreatic Thread Protein; Regenerating Islet-Derived 1 alpha Protein; Regenerating Islet-Derived 1 beta Protein; Regenerating Islet Derived 1 alpha Protein; Regenerating Islet Derived 1 beta Protein; Pancreatic Stone Protein

Networked: 79 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Lithostathine: 79

Experts

1.	Graf, Rolf: 15 articles (09/2015 - 06/2006)
2.	Marchal, Stéphane: 4 articles (02/2012 - 12/2003)
3.	Eggimann, Philippe: 3 articles (09/2015 - 10/2011)
4.	Raptis, Dimitri Aristotle: 3 articles (01/2014 - 01/2012)
5.	Verdier, Jean-Michel: 3 articles (02/2012 - 12/2003)
6.	Bimmler, Daniel: 3 articles (02/2011 - 06/2006)
7.	Hayakawa, Tetsuo: 3 articles (01/2011 - 03/2002)
8.	Ishiguro, Hiroshi: 3 articles (01/2011 - 03/2002)
9.	Kitagawa, Motoji: 3 articles (01/2011 - 03/2002)
10.	Kaneko, Kenitiro: 3 articles (07/2009 - 11/2004)

Related Diseases

1.	Pancreatitis 06/15/2006 - "Regenerating protein (reg) and pancreatic stone protein (PSP) have been discovered independently in the fields of diabetes and pancreatitis. " 02/01/1999 - "Molecular forms of serum pancreatic stone protein in acute pancreatitis." 08/01/1998 - "The hypothesis has been advanced that in chronic calcifying pancreatitis the abnormal biosynthesis of lithostathine might be the original defect to which genetic proneness to the disease may be ascribed. " 05/01/1993 - "Recent literature indicates that a decrease in the activity of pancreatic stone protein (PSP), which inhibits CaCO3 crystal formation in pancreatic juice, is closely related to the development of chronic calcifying pancreatitis. " 09/20/1986 - "Pancreatic stone protein in serum of patients with pancreatitis."
2.	Infection 01/01/2015 - "We investigated the role of pancreatic stone protein (PSP) in predicting the occurrence of infection in the postoperative course of cardiac surgery patients. " 01/01/2012 - "We investigate the prognostic value of pancreatic stone protein/regenerating protein (PSP/reg) concentration in patients with severe infections. " 01/01/2015 - "Pancreatic stone protein predicts postoperative infection in cardiac surgery patients irrespective of cardiopulmonary bypass or surgical technique." 01/01/2012 - "In this issue of Critical Care, Que and colleagues describe the prognostic value of pancreatic stone protein/regenerating protein (PSP/reg) concentration in patients with severe infections. " 01/01/2015 - "In this study, we investigated pancreatic stone protein/regenerating protein in postmortem serum in a series of sepsis-related fatalities, local infections and non-infectious cases that underwent medico-legal investigations. "
3.	Chronic Pancreatitis 11/01/2004 - "Pancreatic stone protein (PSP) is reported to be a key protein to form protein plugs in chronic pancreatitis. " 03/01/2003 - "Human lithostathine was initially isolated from pancreatic stones in patients with alcoholic calcifying chronic pancreatitis. " 05/01/1998 - "A decreased concentration of lithostathine S2-5 seems to increase the risk of stone formation in the ducts during the course of chronic pancreatitis because of insufficient inhibition of CaCO3 crystal growth." 05/01/1998 - "The mean concentrations of lithostathine S2-5 were significantly (p=0.002) lower in chronic pancreatitis, 16.3 microg/mg of total protein, than in the control, 47.1 microg/mg of total protein. " 05/01/1998 - "The concentration of lithostathine S2-5 was compared between control and chronic pancreatitis groups. "
4.	Sepsis (Septicemia) 11/01/2015 - "To evaluate the value of pancreatic stone protein/regenerating protein (PSP/reg) in severity evaluation and prognosis prediction for children with sepsis. " 11/01/2015 - "[Value of pancreatic stone protein/regenerating protein in severity evaluation and prognosis prediction for children with sepsis]." 01/01/2015 - "Pancreatic stone protein (PSP) has been identified as a promising sepsis marker in adults, children and neonates. " 01/01/2015 - "Statistically significant differences in pancreatic stone protein/regenerating protein concentrations were observed between sepsis and control patients. " 04/01/2014 - "Pancreatic stone protein - a possible biomarker of multiorgan failure and mortality in children sepsis."
5.	Pancreatic Diseases (Pancreatic Disease) 04/01/1995 - "This study showed with this assay that lithostathine concentrations (microgram/mg of total protein) were similar in CCP patients with alcoholic aetiology (mean (SD) 6.3 (2.7)) and other aetiologies (7.2 (3.7)), but one third of those estimated in patients without pancreatic disease (16.7 (4.3)). " 04/01/2015 - "Pancreatic stone protein/regenerating protein (PSP/reg) is a secretory protein produced in the pancreas and up-regulated dramatically during pancreatic disease. " 05/01/2009 - "The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease. " 04/01/1993 - "Serum pancreatic stone protein in pancreatic diseases." 08/01/1985 - "Patients with chronic calcifying pancreatitis of different etiologies had significantly lower levels of pancreatic stone protein when compared with other pancreatic diseases and controls. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Lactoferrin
3.	Biological Markers (Surrogate Marker)
4.	Cytokines
5.	pancreatitis-associated protein
6.	Proteins (Proteins, Gene)
7.	Trypsin
8.	Salts
9.	Calcium
10.	Lithostathine

Related Therapies and Procedures

1.	Critical Care
2.	Cardiopulmonary Bypass (Heart-Lung Bypass)