gamma-Synuclein (Persyn)

A homolog of ALPHA-SYNUCLEIN that plays a role in neurofilament network integrity. It is overexpressed in a variety of human NEOPLASMS and may be involved in modulating AXON architecture during EMBRYONIC DEVELOPMENT and in the adult. Gamma-Synuclein may also activate SIGNAL TRANSDUCTION PATHWAYS associated with ETS-DOMAIN PROTEIN ELK-1.

Also Known As:

Networked: 95 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Surguchov, Andrei: 7 articles (12/2008 - 04/2002)
2.	Jiang, Yangfu: 6 articles (01/2022 - 07/2003)
3.	Surgucheva, Irina: 6 articles (12/2008 - 04/2002)
4.	Trojanowski, J Q: 6 articles (09/2001 - 05/2000)
5.	Buchman, Vladimir L: 5 articles (01/2015 - 05/2008)
6.	Lee, V M: 5 articles (04/2001 - 05/2000)
7.	Ninkina, Natalia: 4 articles (01/2015 - 05/2008)
8.	Feng, Bo: 4 articles (06/2010 - 10/2008)
9.	Ye, Qing: 4 articles (06/2010 - 10/2008)
10.	Hua, Hui: 3 articles (01/2022 - 03/2009)

Related Diseases

1.	Glaucoma 12/26/2008 - "gamma-Synuclein (Syn G) is highly expressed in retinal ganglion cells and the loss of these cells in glaucoma is associated with significant reduction of the intracellular Syn G level. " 02/01/2020 - "We used genetic naturally occurring glaucoma (DBA/2J) and experimentally induced optic nerve crush (ONC) as models to study gamma-synuclein expression change in retinal ganglion cells and optic nerves. " 02/01/2020 - "Gene chip microarray analysis demonstrated downregulated expression of the gamma-synuclein gene in DBA/2J mice as they developed age-associated glaucoma with concomitant with retinal ganglion cell loss. " 04/01/2002 - "In the optic nerve from control and glaucomatous individuals, nerve bundles are immunopositive for gamma-synuclein; however, a strong gamma-synuclein-immunopositive staining in a subset of glial cells was observed in the lamina and postlamina cribrosa regions of the optic nerve only in glaucoma patients. " 08/22/2008 - "Previous studies have described gamma-synuclein as a protein highly expressed in retinal ganglion cells (RGCs), and a loss of RGCs correlates with a downregulation of gamma-synuclein gene expression in glaucoma. "
2.	Ovarian Epithelial Carcinoma 06/10/2011 - "In human ovarian cancer epithelial A2780 cells, gamma-synuclein overexpression improved cell adhesion and microtubule structure upon paclitaxel treatment. "
3.	Neoplasms (Cancer) 03/01/2009 - "Previous studies have demonstrated that gamma-synuclein is overexpressed in a variety of human malignancies. " 09/01/1998 - "Detailed characterization of the human persyn locus is important for further studies of the involvement of persyn in neurodegeneration and malignancy." 01/01/2021 - "Gamma-synuclein (SNCG) promotes invasive behavior and is reportedly a prognostic factor in a range of cancers. " 01/01/2018 - "Gamma-synuclein (SNCG) is overexpressed in a variety of invasive and metastatic cancer. " 01/01/2018 - "Gamma synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion."
4.	Parkinson Disease (Parkinson's Disease) 10/01/2003 - "[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease]." 08/01/2009 - "Although beta-syn is a neuroprotective molecule counteracting the alpha-syn pathology in tg mice, it was previously shown that both beta-syn and gamma-synuclein were associated with axonal pathology in the hippocampus of sporadic cases of Parkinson's disease and DLB. " 10/01/2003 - "To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area. " 09/14/2001 - "Evaluation of the gamma-synuclein gene in German Parkinson's disease patients." 01/04/1999 - "No pathogenic mutations in the persyn gene in Parkinson's disease."
5.	Breast Neoplasms (Breast Cancer) 03/01/2009 - "The up-regulation of gamma-synuclein expression by endoplasmic reticulum stress is mediated, at least in part, by activation transcription factor (ATF) 4. Knockdown of gamma-synuclein sensitized human breast cancer cells to endoplasmic reticulum stress-induced apoptosis. " 03/01/2009 - "Overexpression of gamma-synuclein in human breast cancer cells leads to an increase in cell motility, resistance to chemotherapeutic drugs, and mitotic checkpoint dysfunction. " 07/01/2006 - "Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer." 09/01/2003 - "Stage-specific expression of breast cancer-specific gene gamma-synuclein." 05/01/2000 - "Abnormal expression of gamma synuclein has recently been reported in some breast tumors. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Proteins (Proteins, Gene)
3.	Antibodies
4.	alpha-Synuclein
5.	Amyloidogenic Proteins
6.	Janus Kinase 1
7.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
8.	Semaphorin-3A
9.	Fibroblast Growth Factor 1 (FGF-1)
10.	Cadherins (E-Cadherin)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Denervation
4.	Cautery