Transcription Factor RelB

A transcription factor that takes part in the NF-kappa-B complex by interacting with NF-KAPPA B P50 SUBUNIT or NF-KAPPA B P52 SUBUNIT. It regulates GENETIC TRANSCRIPTION that is involved in immune and inflammatory responses.

Also Known As:

Inhibitory Rel Protein; Rel-Related Protein; v-Rel Reticuloendotheliosis Viral Oncogene Homolog B; Rel Protein, Inhibitory; Rel Related Protein; RelB, Transcription Factor; v Rel Reticuloendotheliosis Viral Oncogene Homolog B

Networked: 11 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Guo, Feng: 2 articles (01/2018 - 06/2014)
2.	Xu, Jingjing: 2 articles (01/2018 - 06/2014)
3.	McCall, Charles E: 2 articles (02/2011 - 01/2010)
4.	Yoza, Barbara K: 2 articles (02/2011 - 01/2010)
5.	Han, Jinming: 1 article (12/2019)
6.	Jin, Tao: 1 article (12/2019)
7.	Liang, Hudong: 1 article (12/2019)
8.	Sun, Li: 1 article (12/2019)
9.	Yang, Meng-Ge: 1 article (12/2019)
10.	Zheng, Chao: 1 article (12/2019)

Related Diseases

1.	Sepsis (Septicemia) 02/01/2011 - "In both human sepsis blood leukocytes and an LPS tolerant human THP-1 cell model, we show that IκBα and v-rel reticuloendotheliosis viral oncogene homolog B (RelB) function as dominant labile mediators of fHC formation at the IL-1β promoter. " 01/08/2010 - "We previously reported that NF-kappaB transcription factor RelB and histone H3 lysine methyltransferase G9a directly interact to induce facultative heterochromatin assembly and regulate epigenetic silencing during endotoxin tolerance, which is a major feature of sepsis. "
2.	Infections 08/01/2006 - "Chimeric mice generated with bone marrow from RelB-deficient (-/-), RelB-heterozygous (+/-) and wild-type (+/+) mice were used to determine how total or partial absence of the transcription factor RelB in haematopoietic cells affects the immune response generated after lymphocytic choriomeningitis virus (LCMV) infection. " 01/01/2018 - "Pathway analysis of inflammatory gene expression predicted activation of NF-κB transcription factor RelB and inhibition of bone morphogenetic protein type-2 in the setting of SHIVnef infection. "
3.	Tics (Tic) 12/15/2017 - "Here, we show that in advanced ovarian cancers NFκB signaling via the RelB transcription factor supports TIC populations by directly regulating the cancer stem-like associated enzyme aldehyde dehydrogenase (ALDH). "
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 06/01/2014 - "To investigate the effect of nuclear transcription factor RelB on the proteasome inhibitor-sensitivity of chronic lymphocytic leukemia (CLL) cells. " 06/01/2014 - "[Effect of nuclear transcription factor RelB on the proteasome inhibitor-sensitivity of chronic lymphocytic leukemia cells]."
5.	Virus Diseases (Viral Diseases) 01/01/2018 - "In contrast, transcription factor RelB (RELB), histone acetyltransferase p300 (EP300), acetyl-CoA carboxylase 2 (ACACB), adiponectin (ADIPOQ) and phosphoenolpyruvate carboxykinase 2 mitochondrial (PCK2) had major contributions to viral infections and lipid metabolism as significant events in RP. "

Related Drugs and Biologics

1.	Proteasome Inhibitors
2.	Adiponectin
3.	Histone Acetyltransferases (Histone Acetyltransferase)
4.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
5.	NF-kappa B (NF-kB)
6.	Phosphoenolpyruvate
7.	Methyltransferases
8.	Lysine (L-Lysine)
9.	Histones (Histone)
10.	Heterochromatin