NFI Transcription Factors

Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.

Also Known As:

CAAT Box Transcription Factor; Nuclear Factor I; Nuclear Factor I-A; Nuclear Factor I-B; Nuclear Factor I-C; Nuclear Factor I-X; Nuclear Factor-1; TGGCA-Binding Protein; Nuclear Factor 1; Nuclear Factor I A; Nuclear Factor I B; Nuclear Factor I C; Nuclear Factor I X; TGGCA Binding Protein; Transcription Factors, NFI

Networked: 176 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - NFI Transcription Factors: 176
  - DNA-Binding Proteins: 2009
    - NFI Transcription Factors: 176

Experts

1.	Ellard, S: 5 articles (04/2009 - 11/2000)
2.	Brun, Miranda: 4 articles (01/2019 - 08/2009)
3.	Godbout, Roseline: 4 articles (01/2019 - 08/2009)
4.	Hattersley, A T: 4 articles (04/2009 - 05/2004)
5.	Bunt, Jens: 3 articles (01/2021 - 12/2017)
6.	Richards, Linda J: 3 articles (01/2021 - 12/2017)
7.	Bellanne-Chantelot, Christine: 3 articles (01/2020 - 03/2004)
8.	Giuffrida, Fernando M A: 3 articles (01/2020 - 06/2009)
9.	Monckton, Elizabeth A: 3 articles (01/2019 - 08/2009)
10.	Wollheim, C B: 3 articles (12/2001 - 03/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "In our study, we used The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to investigate that the expression of nuclear factor I B (NFIB) is significantly higher in KIRC than in adjacent tissues. " 01/01/2023 - "Nuclear factor I B (NFIB) plays an important role in tumors. " 06/01/2022 - "Nuclear factor I/B (NFIB), a tumor suppressor gene in various cancers, was predicted to be a potential target of miR-626 by using three algorithms. " 01/01/2022 - "Nuclear factor I (NFI) family is emerging found playing oncogenic or tumor-suppressive potential in cancers. " 02/01/2021 - "The relationship between nuclear factor I/B (NFIB) and cancer attracts growing research interest. "
2.	Carcinoma (Carcinomatosis) 01/01/2020 - "We analyzed P504S expression in 48 cervical carcinomas (32 GAS and 16 CCC), as well as the expression of other markers including hepatocyte nuclear factor-1 beta (HNF-1β) and NapsinA. " 01/01/2020 - "Recently, hepatocyte nuclear factor-1 beta (HNF-1β), a marker for clear cell carcinoma, has also been shown to be positive in mesonephric carcinomas. " 12/01/2018 - "Nuclear factor I X is a recurrent target for HPV16 insertions in anal carcinomas." 12/01/2003 - "Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma." 03/01/2019 - "Recent studies have indicated that a recurrent t(6;9)(q22-23;p23-24) chromosomal translocation in salivary adenoid cystic carcinoma (ACC) results in a MYB proto-oncogene transcription factor-nuclear factor I/B (MYB-NFIB) gene fusion, which has not previously been detected in any non-ACC carcinomas of the head and neck. "
3.	Type 2 Diabetes Mellitus (MODY) 05/01/2013 - "Mutations in the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are the most common cause of MODY in most adult populations studied. " 03/01/2012 - "The patient was investigated for MODY 2 and MODY 3, and a mutation of hepatocyte nuclear factor-1 alpha gene was found. " 01/10/2012 - "In view of her presentation at such a young age and strong family history, a possibility of maturity onset diabetes in young was considered and the genetic test confirmed hepatocyte nuclear factor-1 α mutation on chromosome 12. " 06/02/2009 - "Type 2 diabetes mellitus (T2DM) is a genetically heterogeneous disease, hepatocyte nuclear factor-1 homeobox A (HNF1A) single-nucleotide polymorphisms (SNPs) playing a minor role in its pathogenesis. " 04/01/2003 - "To ascertain whether Ala98Val variant in exon 1 of hepatocyte nuclear factor-1 alpha (HNF-1 alpha) gene is associated with late-onset Type 2 diabetes in Chinese Han nationality. "
4.	Mason-Type Diabetes 01/01/2022 - "Maturity-onset diabetes of the young due to hepatocyte nuclear factor-1 alpha variants (HNF1A-MODY) causes monogenic diabetes. " 01/01/2020 - "Maturity-onset diabetes of the young caused by hepatocyte nuclear factor-1 alpha (HNF1A) variants (HNF1A-MODY) is a common form of monogenetic diabetes. " 12/01/2001 - "Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice." 10/01/1997 - "Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene." 01/01/2020 - "Liver adenomatosis in patients with hepatocyte nuclear factor-1 alpha maturity onset diabetes of the young (HNF1A-MODY): Clinical, radiological and pathological characteristics in a French series."
5.	Glioma (Gliomas) 12/30/2019 - "Circular RNA nuclear factor I X (circNFIX) has been reported to play an important role in glioma progression. " 01/01/2019 - "Effects of nuclear factor I phosphorylation on calpastatin (CAST) gene variant expression and subcellular distribution in malignant glioma cells." 08/16/2013 - "Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines." 09/29/2000 - "Regulation of brain fatty acid-binding protein expression by differential phosphorylation of nuclear factor I in malignant glioma cell lines." 01/01/2017 - "The nuclear factor I-A (NFIA) transcription factor promotes glioma growth and inhibits apoptosis in glioblastoma (GBM) cells. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	RNA (Ribonucleic Acid)
3.	Insulin (Novolin)
4.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
5.	Phosphoric Monoester Hydrolases (Phosphatases)
6.	Circular RNA
7.	Temozolomide (Temodar)
8.	COUP Transcription Factor II
9.	Cyclooxygenase 2 (Cyclooxygenase-2)
10.	Tretinoin (Retinoic Acid)

Related Therapies and Procedures

1.	Therapeutics