Inhibitor of Differentiation Protein 1

A HELIX-LOOP-HELIX MOTIF-containing negative regulator of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS that blocks activation of CYCLIN-DEPENDENT KINASE INHIBITOR P16 and is de-regulated in a variety of NEOPLASMS.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baker, Laura A: 1 article (01/2020)
2.	Cazet, Aurélie S: 1 article (01/2020)
3.	Chan, Chia-Ling: 1 article (01/2020)
4.	Harvey, Kate: 1 article (01/2020)
5.	Holliday, Holly: 1 article (01/2020)
6.	Junankar, Simon: 1 article (01/2020)
7.	Kaplan, Warren: 1 article (01/2020)
8.	Karthikeyan, Nitheesh: 1 article (01/2020)
9.	Konrad, Christina Valbirk: 1 article (01/2020)
10.	Lakhani, Sunil R: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "Further functional analyses indicated that water eluate fraction and p38 inhibitor treatment exerted a synergic inhibitory effect on cancer cells growth, which was related to their suppressive effect on expression level of ID1 (inhibitor of differentiation protein 1), which was highly expressed in cancer cells. " 06/01/2002 - "The radiosensitivity gene ATDC and the genes encoding the DNA-binding protein inhibitor ID1 and the phospholipase inhibitor uteroglobin were significantly down-regulated in the cancer samples. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "The Inhibitor of Differentiation Protein 1 (Id1) and its closely related family member Inhibitor of Differentiation 3 (Id3) (collectively termed Id) are expressed by a diversity of stem cells and are required for metastatic dissemination in experimental models of breast cancer. " 12/01/2009 - "We report here a novel function for Abi1 in the regulation of invadopodia formation and Src-inhibitor of differentiation protein 1 (Id1)-matrix metalloproteinase (MMP)-9 pathway in MDA-MB-231 human breast cancer cells. "
3.	Vascular Remodeling 01/01/2013 - "Furthermore, sildenafil restored the antiproliferative response to BMP4 in PASMCs harboring mutations in BMPR-II. In the monocrotaline rat model of PAH, which is characterized by BMPR-II deficiency, sildenafil prevented the development of pulmonary hypertension and vascular remodeling, and partly restored Smad1/5 phosphorylation and Inhibitor of DNA binding protein 1 gene expression in vivo in monocrotaline exposed rat lungs. "
4.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2014 - "Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. " 07/01/2014 - "Inhibitor of DNA-binding protein 1 knockdown arrests the growth of colorectal cancer cells and suppresses hepatic metastasis in vivo."
5.	Neoplasm Metastasis (Metastasis) 07/01/2014 - "Inhibitor of DNA-binding protein 1 knockdown arrests the growth of colorectal cancer cells and suppresses hepatic metastasis in vivo."

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Monocrotaline
3.	Uteroglobin
4.	Phospholipases (Phospholipase)
5.	Sildenafil Citrate (Viagra)