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Von Hippel-Lindau Tumor Suppressor Protein

A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
Also Known As:
VHL Tumor Suppressor Protein; Von Hippel Lindau Tumor Suppressor Protein
Networked: 118 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kaelin, William G: 12 articles (01/2022 - 02/2003)
2. Ohh, Michael: 10 articles (11/2019 - 03/2003)
3. Shah, Yatrik M: 4 articles (01/2013 - 06/2008)
4. Lee, Stephen: 4 articles (02/2009 - 08/2002)
5. Minervini, Giovanni: 3 articles (01/2019 - 07/2015)
6. Tosatto, Silvio C E: 3 articles (01/2019 - 07/2015)
7. Krek, Wilhelm: 3 articles (05/2014 - 08/2007)
8. Gonzalez, Frank J: 3 articles (05/2012 - 06/2008)
9. Simon, M Celeste: 3 articles (05/2010 - 12/2007)
10. Khacho, Mireille: 3 articles (02/2009 - 08/2004)

Related Diseases

1. Hypoxia (Hypoxemia)
2. Renal Cell Carcinoma (Grawitz Tumor)
3. Neoplasms (Cancer)
4. Carcinogenesis
5. Kidney Neoplasms (Kidney Cancer)

Related Drugs and Biologics

1. Oxygen (Dioxygen)
2. Transcription Factors (Transcription Factor)
3. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5. Ubiquitin
6. Proteins (Proteins, Gene)
7. Ligases (Synthetase)
8. Elongin
9. Messenger RNA (mRNA)
10. Prolyl Hydroxylases (Prolyl Hydroxylase)

Related Therapies and Procedures

1. Therapeutics
2. Ligation