Hypoxia-Inducible Factor 1

A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.

Also Known As:

Networked: 1411 relevant articles (11 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Semenza, Gregg L: 64 articles (03/2021 - 01/2002)
2.	Harada, Hiroshi: 18 articles (06/2021 - 09/2008)
3.	Hirota, Kiichi: 12 articles (01/2015 - 10/2002)
4.	Brüne, Bernhard: 12 articles (09/2014 - 04/2004)
5.	Harris, Adrian L: 10 articles (12/2015 - 01/2004)
6.	Park, Jong-Wan: 9 articles (08/2021 - 04/2003)
7.	Hiraoka, Masahiro: 9 articles (03/2018 - 09/2008)
8.	Luo, Weibo: 8 articles (01/2021 - 05/2011)
9.	Gilkes, Daniele M: 8 articles (11/2020 - 09/2011)
10.	Simos, George: 8 articles (04/2013 - 08/2006)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2020 - "In this study, we not only provide convincing evidence that hypoxia exists during endometrial breakdown, but also further explore the role of hypoxia and hypoxia-inducible factor 1 (HIF1) in this process. " 02/16/2017 - "The present study was designed to test the hypothesis that the hypoxia-induced increase in P4 synthesis during luteinization in bovine GCs is mediated by hypoxia-inducible factor 1 (HIF-1). " 05/10/2016 - "In this study, we investigated the role of HIF-1 α (hypoxia-inducible factor -1 alpha) in the inflammatory process induced by hypoxia. " 12/15/2012 - "The aim of this study was to test the effect of hypoxia and its master transcriptional regulator hypoxia-inducible factor 1 (HIF-1) on S100A8/A9 expression. " 12/01/2012 - "The study objective was to investigate the role of hypoxia-inducible factor 1 (HIF-1) in the transcriptional activation of MUC5AC in human bronchial epithelial (HBE) 16 cells under hypoxia conditions and the effect of hypoxia on expression and secretion of MUC5AC. "
2.	Neoplasms (Cancer) 06/01/2008 - "To enhance the efficacy of cancer treatment, we propose a complex approach: simultaneous delivery to the tumor of a chemotherapeutic agent and a suppressor of hypoxia-inducible factor 1 alpha (HIF1A). " 10/01/2020 - "Although many studies have revealed essential roles of HIF1A (hypoxia inducible factor 1 subunit alpha) in regulating various pathways associated with cancer development, a systematic investigation of associations of HIF1A expression with tumor immunity, the tumor microenvironment and other tumor phenotypes in pan-cancer is lacking. " 01/01/2014 - "The results from the published studies on the association between hypoxia-inducible factor-1(Hif-1/HIF-1) polymorphisms and cancer risk are conflicting. " 01/01/2023 - "Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. " 10/01/2022 - "Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular responses to hypoxic stress, is essential for tumor progression. "
3.	Ischemia 01/01/2019 - "MicroRNA-7b attenuates ischemia/reperfusion-induced H9C2 cardiomyocyte apoptosis via the hypoxia inducible factor-1/p-p38 pathway." 01/01/2016 - "Hypoxia-inducible factor 1-α (HIF1-α), rapidly degraded during normoxia, is stabilized during ischemia and upregulates various cardioprotective genes. " 02/01/2015 - "Hypoxia-inducible factor 1-α in chronic gastrointestinal ischemia." 01/01/2015 - "Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic response and has been a prime therapeutic target for ischemia/reperfusion (I/R)-derived myocardial dysfunction and tissue damage. " 12/04/2012 - "To explore the expression of hypoxia-inducible factor 1 alpha (HIF-1a) in rat lower limb skeletal muscle with acute ischemia. "
4.	Carcinoma (Carcinomatosis) 07/01/2017 - "This meta-analysis was carried out to explore hypoxia inducible factor 1 alpha in esophageal carcinoma and its correlation with clinicopathological features and prognosis, in order to provide comprehensive reference for clinic. " 07/01/2017 - "Expression of hypoxia inducible factor 1 alpha and its clinical significance in esophageal carcinoma: A meta-analysis." 01/01/2012 - "Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells." 05/01/2008 - "To observe the influence of hypoxia-inducible factor 1 alpha (HIF-1alpha) on angiogenesis in prostate carcinoma in vivo and to investigate its molecular mechanism. " 08/01/2007 - "Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma."
5.	Inflammation (Inflammations) 01/01/2022 - "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation." 12/01/2019 - "Hypoxia-inducible factor 1 (HIF-1) has several roles in cells, such as inducing inflammation and angiogenesis. " 02/01/2019 - "In this study, we examined the kinetics of endodontic infection-induced inflammation in TLR2/IL-10 dKO mice and explored a potential mechanism of periapical wound healing mediated by the hypoxia-inducible factor 1 alpha (HIF-1α) subunit and arginase 1. " 11/01/2018 - "DEX targets chronic inflammation while DNR inhibits excessive cell proliferation as well as suppresses hypoxia-inducible factor 1 to reduce scarring. " 01/01/2018 - "Here, we aimed to investigate the underlying mechanism of hypoxia interaction with inflammation in ALI and to evaluate hypoxia-inducible factor 1 alpha (HIF-1α)-the crucial modulator in hypoxia-as a potential therapeutic target against ALI. "

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