Hypoxia-Inducible Factor 1

A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.

Also Known As:

Networked: 791 relevant articles (4 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Semenza, Gregg L: 55 articles (11/2015 - 01/2002)
2.	Hirota, Kiichi: 12 articles (01/2015 - 10/2002)
3.	Brüne, Bernhard: 12 articles (09/2014 - 04/2004)
4.	Harris, Adrian L: 10 articles (12/2015 - 01/2004)
5.	Harada, Hiroshi: 10 articles (01/2015 - 09/2008)
6.	Simos, George: 8 articles (04/2013 - 08/2006)
7.	Fandrey, Joachim: 8 articles (06/2012 - 09/2004)
8.	Zhou, Jie: 8 articles (09/2009 - 04/2004)
9.	Gilkes, Daniele M: 7 articles (11/2015 - 09/2011)
10.	Hiraoka, Masahiro: 7 articles (01/2015 - 09/2008)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2008 - "To enhance the efficacy of cancer treatment, we propose a complex approach: simultaneous delivery to the tumor of a chemotherapeutic agent and a suppressor of hypoxia-inducible factor 1 alpha (HIF1A). " 01/01/2014 - "The results from the published studies on the association between hypoxia-inducible factor-1(Hif-1/HIF-1) polymorphisms and cancer risk are conflicting. " 11/01/2015 - "Furthermore, low doses of LMP-400 decreased the protein levels of hypoxia-inducible factor 1 (HIF-1α), one of a family of factors studied as potential metastatic drivers in these tumors. " 01/28/2015 - "Moreover, the antitumor activity of LCL-SIM depends on the presence of functional tumor-associated macrophages (TAM) in tumor tissue and is mainly based on the reduction of the TAM-mediated oxidative stress as well as of the production of the hypoxia-inducible factor 1 α (HIF-1 α) in tumors. " 07/01/2014 - "Microvascular density (MVD), Ki67 tumor cell proliferation index and hypoxia-inducible factor 1 alpha (HIF-1 alpha) index were determined by immunohistochemistry. "
2.	Carcinoma (Carcinomatosis) 03/01/2010 - "Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas." 05/01/2008 - "To observe the influence of hypoxia-inducible factor 1 alpha (HIF-1alpha) on angiogenesis in prostate carcinoma in vivo and to investigate its molecular mechanism. " 08/01/2007 - "Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma." 03/01/2003 - "Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1." 02/25/2002 - "Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma."
3.	Reperfusion Injury 01/01/2014 - "Hypoxia-inducible factor 1 alpha contributes to pulmonary vascular dysfunction in lung ischemia-reperfusion injury." 06/20/2011 - "The aim of this study was to investigate whether isoflurane preconditioning provides a protection against renal ischemic-reperfusion injury and whether hypoxia inducible factor 1 α (HIF-1 α) is responsible for the protection afforded by isoflurane in mice. " 04/01/2010 - "[Isoflurane produces delayed preconditioning against renal ischemia/reperfusion injury via hypoxia inducible factor 1 alpha activation]."
4.	Unstable Angina 11/01/2008 - "Expression of hypoxia-inducible factor 1 alpha regulated genes was not influenced by cardioplegia and reperfusion, ischemic preconditioning or unstable angina. " 11/01/2008 - "We hypothesized that preceding unstable angina and/or ischemic preconditioning activated genes regulated by nuclear factor kappa B (NFkappaB) or hypoxia-inducible factor 1 alpha in parallel to improved cardiac function. " 11/01/2008 - "Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart."
5.	Anoxia (Hypoxia) 12/15/2012 - "The aim of this study was to test the effect of hypoxia and its master transcriptional regulator hypoxia-inducible factor 1 (HIF-1) on S100A8/A9 expression. " 12/01/2012 - "The study objective was to investigate the role of hypoxia-inducible factor 1 (HIF-1) in the transcriptional activation of MUC5AC in human bronchial epithelial (HBE) 16 cells under hypoxia conditions and the effect of hypoxia on expression and secretion of MUC5AC. " 12/01/2009 - "The purpose of this study was to construct a novel mutant TKGFP fusion reporter gene with low cytotoxicity and high temporal resolution for use in the real-time monitoring of temporal dynamics and spatial heterogeneity of hypoxia-inducible factor 1 (HIF-1) signal transduction activity mediated by hypoxia and reoxygenation in vitro and in vivo. " 11/01/2006 - "In this study, we specifically investigated the role of hypoxia inducible factor 1 alpha (HIF-1alpha) in the hepatocellular response to hypoxia. " 11/01/2006 - "In this study we tested the hypothesis that hypoxia-induced changes in PASMC pH homeostasis are mediated by the transcriptional regulator hypoxia-inducible factor 1 (HIF-1). "

Related Drugs and Biologics

1.	Isoflurane
2.	NF-kappa B (NF-kB)
3.	Topotecan (Hycamtin)
4.	Antisense Oligonucleotides
5.	130-nm albumin-bound paclitaxel
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Messenger RNA (mRNA)
8.	Transcription Factors (Transcription Factor)
9.	Carbonic Anhydrases (Carbonic Anhydrase)
10.	Oxygen

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Cystectomy
4.	Lasers (Laser)
5.	Heterologous Transplantation (Xenotransplantation)