Aryl Hydrocarbon Receptor Nuclear Translocator

Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.

Also Known As:

Networked: 125 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chang, Wen-Chang: 4 articles (05/2015 - 04/2009)
2.	Chen, Ben-Kuen: 4 articles (05/2015 - 04/2009)
3.	Gonzalez, Frank J: 4 articles (06/2011 - 11/2003)
4.	Depping, Reinhard: 3 articles (01/2015 - 01/2013)
5.	Whitelaw, Murray L: 3 articles (06/2013 - 02/2004)
6.	Shah, Yatrik M: 3 articles (10/2012 - 06/2008)
7.	Park, Jong-Wan: 3 articles (02/2009 - 01/2004)
8.	Chun, Yang-Sook: 3 articles (02/2009 - 01/2004)
9.	Chang, Kwang-Yu: 2 articles (05/2015 - 04/2009)
10.	Mandl, Markus: 2 articles (01/2015 - 01/2014)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 06/19/1998 - "Studies in mutant hepatoma cells indicate that induction requires both the aromatic hydrocarbon receptor (AhR) and the AhR nuclear translocator (Arnt). " 04/15/2012 - "Here, we investigated the role of aryl hydrocarbon receptor nuclear translocator (ARNT), another bHLH/PAS protein, in hepatocellular carcinoma (HCC). " 01/01/2005 - "We assayed the capacity of extracts of these fruits and vegetables to induce NQO1 [by more than 1.5-fold: ratio of induction (cells treated/control) >1.5, 8-mg/ml dose] in two murine hepatoma cell lines: Hepa 1c1c7 and BPrC1, a modified cell line that possesses a nonfunctional aryl hydrocarbon receptor nuclear translocator system and is thus nonresponsive to bifunctional inducers. " 04/15/2012 - "Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma." 02/01/2010 - "c4 is a derivative of the mouse hepatoma cell line, Hepa-1, that harbors a mutation in the aryl hydrocarbon receptor nuclear translocator gene (Arnt, or hypoxia inducible factor 1beta [HIF-1beta]) leading to loss of activity. "
2.	Neoplasms (Cancer) 05/10/2015 - "The aryl hydrocarbon receptor nuclear translocator (ARNT) is broadly involved in regulating tumorigenesis by inducing genes that are involved in tumor growth and angiogenesis. " 01/01/2014 - "The aryl hydrocarbon receptor nuclear translocator (ARNT) is an important mediator of tumor progression. " 10/01/2010 - "Similar to human AIP-deficient pituitary adenomas, immunohistochemical studies showed that expression of aryl hydrocarbon receptor nuclear translocator 1 or 2 (ARNT or ARNT2) protein was lost in the mouse tumors, suggesting that mechanisms of AIP-related tumorigenesis involve aberrant ARNT function. " 01/01/2014 - "Dimerization of hypoxia-inducible factor-1 beta (HIF-1β) [aryl hydrocarbon receptor nuclear translocator (ARNT)] with HIF-1α is involved in various aspects of cancer biology, including proliferation and survival under hypoxic conditions. " 04/15/2012 - "Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma."
3.	Breast Neoplasms (Breast Cancer) 10/20/2011 - "Recent human studies found that the mRNA expression level of aryl-hydrocarbon receptor nuclear translocator 2 (ARNT2) was positively associated with the prognosis of breast cancer. " 10/20/2011 - "siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells." 03/01/2014 - "In this study, we used zinc finger nuclease-mediated knockout of the aryl hydrocarbon receptor (AHR) or AHR nuclear translocator (ARNT) in MCF7 and AHR knockout in MDA-MB-231 human breast cancer cells to investigate cross talk among AHR, ARNT, and estrogen receptor α (ERα). " 10/10/2011 - "Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism." 06/01/2003 - "Transfection of siRNAs for the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) mRNAs in MCF-7 breast cancer cells resulted in a 60 to 80% decrease in levels of AhR and ARNT proteins in whole-cell extracts and decreased binding of nuclear extracts to 32P-labeled dioxin-responsive element. "
4.	Anoxia (Hypoxia) 01/01/2014 - "In the present study we demonstrate that the aryl hydrocarbon receptor nuclear translocator (Arnt), which is central in hypoxia-induced signaling, forms a complex with Miz-1, an important transcriptional regulator in Myc-mediated transcriptional repression. " 12/01/2015 - "Increasing evidence indicates that AhR might compete with AhR nuclear translocator (ARNT) for complex formation with hypoxia-inducible factor-1α (HIF-1α) for transactivation, which could alter several physiological variables. " 07/18/2014 - "We have previously shown that ERβ suppresses hypoxia inducible factor (HIF)-1-mediated transcription through aryl hydrocarbon receptor nuclear translocator (ARNT) degradation via ubiquitination processes. " 06/01/2014 - "The hypoxia-inducible factors HIF-1α or HIF-2α form heterodimeric complexes with the aryl hydrocarbon receptor nuclear translocator (ARNT). " 02/01/2014 - "Activation of AhR responsive genes requires AhR dimerization with the aryl hydrocarbon receptor nuclear translocator (ARNT), a heterodimeric partner also shared by the hypoxia-inducible factor-1α (HIF-1α) protein. "
5.	Pituitary Neoplasms (Pituitary Adenoma) 10/01/2010 - "Similar to human AIP-deficient pituitary adenomas, immunohistochemical studies showed that expression of aryl hydrocarbon receptor nuclear translocator 1 or 2 (ARNT or ARNT2) protein was lost in the mouse tumors, suggesting that mechanisms of AIP-related tumorigenesis involve aberrant ARNT function. " 12/01/2009 - "The expressions of the AIP-related proteins aryl hydrocarbon receptor (AHR), AHR nuclear translocator (ARNT), cyclin-dependent kinase inhibitor 1B encoding p27(Kip1), and hypoxia-inducible factor 1-alpha were examined in 14 AIPmut+ and 53 AIPmut- pituitary adenomas to detect possible expression differences. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Cytochrome P-450 CYP1A1 (CYP1A1)
3.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
4.	Proteins (Proteins, Gene)
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	Estrogens (Estrogen)
7.	cytochrome P-450 CYP1B1 (CYP1B1)
8.	Luciferases
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Lipopolysaccharides