Sterol Regulatory Element Binding Protein 2

A sterol regulatory element binding protein that regulates GENES involved in CHOLESTEROL synthesis and uptake.

Also Known As:

SRE-2 Binding Protein; SREBP2 Protein; Sterol-Regulatory Element-Binding Protein 2; SRE 2 Binding Protein

Networked: 52 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        Sterol Regulatory Element Binding Proteins: 237
        Sterol Regulatory Element Binding Protein 2: 52
        human SREBF2 protein
        mouse Srebf2 protein
    - Basic-Leucine Zipper Transcription Factors: 187
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        Sterol Regulatory Element Binding Proteins: 237
        Sterol Regulatory Element Binding Protein 2: 52
        human SREBF2 protein
        mouse Srebf2 protein
  - DNA-Binding Proteins: 2009
    - Basic Helix-Loop-Helix Transcription Factors: 510
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        Sterol Regulatory Element Binding Proteins: 237
        Sterol Regulatory Element Binding Protein 2: 52
        human SREBF2 protein
        mouse Srebf2 protein
    - Basic-Leucine Zipper Transcription Factors: 187
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors: 3
        Sterol Regulatory Element Binding Proteins: 237
        Sterol Regulatory Element Binding Protein 2: 52
        human SREBF2 protein
        mouse Srebf2 protein

Experts

1.	Liu, Xiaoyu: 2 articles (01/2022 - 01/2022)
2.	Hamakubo, Takao: 2 articles (01/2017 - 07/2010)
3.	Kodama, Tatsuhiko: 2 articles (01/2017 - 07/2010)
4.	Sakai, Juro: 2 articles (01/2017 - 07/2010)
5.	Chen, Zhen: 2 articles (10/2014 - 08/2013)
6.	Chan, Anthony W H: 1 article (01/2022)
7.	Cheng, Alfred S L: 1 article (01/2022)
8.	Egawa, Naohiro: 1 article (01/2022)
9.	Enami, Takako: 1 article (01/2022)
10.	Feng, Yu: 1 article (01/2022)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2023 - "Specifically, hypoxia reduced cholesterol biosynthesis flux and provoked a compensatory activation of sterol regulatory element-binding protein 2 (SREBP2) in monocytes. " 01/01/2020 - "Docking studies revealed a strong affinity of AGP versus NF-kB (- 6.8 kcal/mol), DPA versus Cutlike-homeobox (- 5.1 kcal/mol), BPP versus Hypoxia inducing factor 1 (- 7.7 kcal/mol), ATS versus Sterol Regulatory Element Binding Protein 2 (- 7.2 kcal/mol), BZS versus Ephrin type-A receptor 2 (- 4.4 kcal/mol) and TCD versus Ying Yang 1 (- 9.4 kcal/mol). " 09/01/2023 - "High glucose also interferes with lipid metabolism and glycolysis by activating the sterol-regulatory element-binding protein-2/cleavage-activating protein pathway and increasing hypoxia inducible factor-1α expression, leading to angiogenesis and peritoneal fibrosis. " 01/01/2023 - "Mechanistically, intermittent hypoxia-induced SREBP2 (sterol regulatory element-binding protein 2) bound to the promoter region of miR-210, which in turn inhibited the iron-sulfur cluster assembly enzyme and led to mitochondrial dysfunction. "
2.	Obesity 06/18/2014 - "To study the relationship between rs2228314 polymorphism in sterol regulatory element binding protein 2 gene (SREBP2) and obesity, serum lipid levels in children and adolescents. " 05/18/2001 - "We show here that sterol regulatory element-binding protein 2 (SREBP-2) and its target genes are induced in the adipose tissue of several models of rodent obesity, suggesting cholesterol imbalance in enlarged adipocytes. " 01/01/2022 - "Mechanistically, sterol regulatory element-binding protein 2 (SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells, which were supported by findings in people with obesity, NAFLD and NAFLD-HCC. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2017 - "Studies performed in vitro revealed that treatment of prostate cancer cells with 27-hydroxycholesterol (27HC), an enzymatic product of CYP27A1, reduced cellular cholesterol content in prostate cancer cell lines by inhibiting the activation of sterol regulatory-element binding protein 2 and downregulating low-density lipoprotein receptor expression. " 12/30/2009 - "It has been previously reported that in vitro, prostate cancer cells lack sterol-mediated feedback regulation of the major transcription factor in cholesterol homeostasis, sterol-regulatory element binding protein 2 (SREBP-2). "
4.	Breast Neoplasms (Breast Cancer) 01/01/2019 - "In this study, we demonstrated that important roles sterol regulatory element-binding protein 2 (SREBP-2) play in osteoclast formation a function, and in breast cancer metastasis. " 09/25/2022 - "Fatostatin (Fato), an inhibitor of sterol-regulatory element binding protein 2 (SREBP2), was reported as a synergistic inhibitor of ER-positive breast cancer with TMX, but the hepatic lipid regulation of this combination is still unknown. "
5.	Tuberous Sclerosis (Bourneville's Disease) 01/01/2022 - "Subsequent functional studies revealed that miR-673-5p targets the regulator of mechanistic target of the rapamycin (mTOR) complex 1 (mTORC1) tuberous sclerosis complex 2 in SCs, leading to the activation of downstream signaling pathways including mTORC1 and sterol-regulatory element binding protein 2. In vivo experiments further confirmed that miR-673-5p activates the tuberous sclerosis complex 2/mTORC1/sterol-regulatory element binding protein 2 axis, thus promoting the synthesis of cholesterol and related lipids and subsequently accelerating myelin sheath maturation in peripheral nerves. "

Related Drugs and Biologics

1.	Cholesterol
2.	Lipids
3.	LDL Receptors (LDL Receptor)
4.	Sirtuin 1
5.	Amyloid Precursor Protein Secretases (beta-Secretase)
6.	Ephrins
7.	Sirolimus (Rapamycin)
8.	NF-kappa B (NF-kB)
9.	Mechanistic Target of Rapamycin Complex 1
10.	27-hydroxycholesterol