Transcription Factor TFIIH

A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.

Also Known As:

BTF2 Transcription Factor; Basic Transcription Factor 2; Transcription Factor BTF2; Transcription Factor IIH; BTF2, Transcription Factor; TFIIH, Transcription Factor; Transcription Factor, BTF2; Transcription Factor, TFIIH; TFIIH Transcription Factor

Networked: 77 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - General Transcription Factors: 14
      - TFII Transcription Factors: 1
        Transcription Factor TFIIH: 77
        Xeroderma Pigmentosum Group D Protein: 3
        Drosophila mrn protein
        human GTF2H1 protein
        human p34 TFIIH subunit
        human p44 TFIIH subunit
        mouse Gtf2h1 protein
        S cerevisiae CCL1 protein
        S cerevisiae SSL1 protein
        S cerevisiae SSL2 protein
        S cerevisiae Tfb2 protein
        S cerevisiae Tfb5 protein
        S pombe Ptr8 protein
  - DNA-Binding Proteins: 2009
    - General Transcription Factors: 14
      - TFII Transcription Factors: 1
        Transcription Factor TFIIH: 77
        Xeroderma Pigmentosum Group D Protein: 3
        Drosophila mrn protein
        human GTF2H1 protein
        human p34 TFIIH subunit
        human p44 TFIIH subunit
        mouse Gtf2h1 protein
        S cerevisiae CCL1 protein
        S cerevisiae SSL1 protein
        S cerevisiae SSL2 protein
        S cerevisiae Tfb2 protein
        S cerevisiae Tfb5 protein
        S pombe Ptr8 protein

Experts

1.	Egly, Jean-Marc: 9 articles (02/2015 - 11/2002)
2.	Compe, Emmanuel: 5 articles (01/2021 - 11/2007)
3.	Botta, Elena: 4 articles (01/2021 - 11/2002)
4.	Orioli, Donata: 3 articles (01/2021 - 02/2015)
5.	Hoeijmakers, Jan H J: 3 articles (01/2019 - 07/2004)
6.	Lehmann, Alan: 3 articles (01/2019 - 11/2006)
7.	Raams, Anja: 3 articles (01/2019 - 07/2004)
8.	Stefanini, Miria: 3 articles (02/2015 - 11/2002)
9.	Ibuki, Yuko: 2 articles (07/2022 - 01/2022)
10.	Komaki, Yukako: 2 articles (07/2022 - 01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Using biophysical methods during the current study, we have screened 76 compounds (grouped into 16 mixtures) against the p8 subunit of the general transcription factor (TFIIH), which has recently been validated as an anti-cancer drug target. " 01/01/2020 - "Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. " 01/01/2018 - "Covalent CDK7 inhibitor THZ1 is a newly discovered anti-tumor drug.THZ1 affects the function of transcription factor TFIIH by inhibiting CDK7, which in turn affects RNA polymerase II, and ultimately affects transcription initiation. " 10/10/2017 - "Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. " 02/03/2015 - "Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in distinct clinical entities, including the cancer-prone xeroderma pigmentosum (XP) and the multisystem disorder trichothiodystrophy (TTD), which share only cutaneous photosensitivity. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 09/01/2018 - "In this study, we aimed to evaluate the association of 10 single nucleotide polymorphisms (SNPs) of the Fas cell surface death receptor (FAS), trinucleotide repeat containing 6C (TNRC6C), transmembrane channel like 8 (TMC8), DNA meiotic recombinase 1 (DMC1), deoxyuridine triphosphatase (DUT), sulfatase 1 (SULF1), 2'-5-oligoadenylate synthetase 3 (OAS3), general transcription factor IIH subunit 4 (GTF2H4) and interferon gamma (IFNG) genes with susceptibility to precancerous lesions and cervical cancer. "
3.	Xeroderma Pigmentosum (Kaposi's Disease) 08/01/2020 - "The xeroderma pigmentosum group D (XPD) gene is a member of the transcription factor IIH complex and serves an important role in gene repair. " 04/07/2016 - "The xeroderma pigmentosum group D (XPD) helicase is a component of the transcription factor IIH complex in eukaryotes and plays an essential role in DNA repair in the nucleotide excision repair pathway. " 05/29/2015 - "Xeroderma pigmentosum group D (XPD) helicase is a component of the transcription factor IIH (TFIIH) transcription complex and plays essential roles in transcription and nucleotide excision repair. " 01/01/2013 - "TTD is caused primarily by mutations in the xeroderma pigmentosum group D (XPD) gene, which encodes a subunit of the basal transcription factor IIH. " 04/01/1994 - "Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)."
4.	Trichothiodystrophy Syndromes 12/22/2018 - "The genes associated to photosensitive trichothiodystrophy encode subunits of transcription factor IIH, involved in the nucleotide excision repair pathway. " 10/01/2014 - "To further grasp the molecular mechanisms that govern transcription, we focused our attention on the general transcription factor TFIIH, which gives rise, once mutated, to Trichothiodystrophy (TTD), a rare autosomal premature-ageing disease causing inter alia, metabolic dysfunctions. " 08/01/2012 - "Trichothiodystrophy (TTD) is a rare, autosomal recessive nucleotide excision repair (NER) disorder caused by mutations in components of the dual functional NER/basal transcription factor TFIIH. " 10/15/2009 - "Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH." 08/02/2008 - "Mutations in three of the genes encoding the XPB, XPD and TTDA components of transcription factor TFIIH can result in the clinical phenotype of trichothiodystrophy (TTD). "
5.	Complementation Group B Xeroderma Pigmentosum 07/05/1996 - "A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription." 10/11/1994 - "The XPB/ERCC3 gene corrects the nucleotide excision-repair defect in the human hereditary disease xeroderma pigmentosum group B and encodes the largest subunit of the basal transcription factor BTF2/TFIIH. " 06/01/1994 - "The human ERCC3 gene, which corrects specifically the nucleotide excision repair defect in human xeroderma pigmentosum group B and cross-complements the repair deficiency in rodent UV-sensitive mutants of group 3, encodes a presumed DNA helicase that is identical to the p89 subunit of the general transcription factor TFIIH/BTF2. " 01/01/2020 - "Since spironolactone causes degradation of xeroderma pigmentosum group B-complementing protein (XPB), a component of human transcription factor TFIIH, in both B lymphocytes and epithelial cells, we hypothesized that SM utilizes XPB to specifically activate transcription of SM target promoters. " 11/01/2000 - "The p89/xeroderma pigmentosum complementation group B (XPB) ATPase-helicase of transcription factor IIH (TFIIH) is essential for promoter melting prior to transcription initiation by RNA polymerase II (RNAPII). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	DNA (Deoxyribonucleic Acid)
3.	Sulfatases
4.	DNA-Directed RNA Polymerases (RNA Polymerase)
5.	Interferon-gamma (Interferon, gamma)
6.	Histone Chaperones
7.	Recombinases (Recombinase)
8.	fas Receptor (CD95 Antigen)
9.	Nucleosomes (Nucleosome)
10.	Ligases (Synthetase)

Related Therapies and Procedures

1.	Treatment Delay