Leucine-Responsive Regulatory Protein

A LEUCINE and DNA-binding protein that is found primarily in BACTERIA and ARCHAEA. It regulates GENETIC TRANSCRIPTION involved in METABOLISM of AMINO ACIDS in response to the increased concentration of LEUCINE.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Choi, Garam: 1 article (01/2020)
2.	Choi, Sang Ho: 1 article (01/2020)
3.	Chung, Kyung Min: 1 article (01/2020)
4.	Hwang, Seung-Ho: 1 article (01/2020)
5.	Jang, Kyung Ku: 1 article (01/2020)
6.	Kim, Byoung Sik: 1 article (01/2020)
7.	Lee, Tae Hee: 1 article (01/2020)
8.	Lee, Zee-Won: 1 article (01/2020)
9.	Jiao, Lingxia: 1 article (01/2019)
10.	Liang, Xinhong: 1 article (01/2019)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2020 - "In this study, we found that a leucine-responsive regulatory protein (Lrp) activates rtxA by binding directly and specifically to the rtxA promoter, P rtxA Phased hypersensitivity resulting from DNase I cleavage of the P rtxA regulatory region suggests that Lrp probably induces DNA bending in P rtxA Lrp activates P rtxA independently of H-NS and HlyU, and leucine inhibits Lrp binding to P rtxA and reduces the Lrp-mediated activation. "
2.	Pyelonephritis 12/01/1995 - "Pyelonephritis-associated pili (Pap) expression in Escherichia coli is subject to a phase variation control mechanism that is regulated by the leucine-responsive regulatory protein (Lrp), PapI, and deoxyadenosine methylase (Dam). " 04/01/2005 - "Pyelonephritis-associated pili (Pap) expression in uropathogenic Escherichia coli is regulated by a complex phase variation mechanism involving the competition between leucine-responsive regulatory protein (Lrp) and DNA adenine methylase (Dam). " 09/01/1992 - "Pyelonephritis-associated pilus (Pap) expression is regulated by a phase variation control mechanism involving PapB, Papl, catabolite activator protein (CAP), leucine-responsive regulatory protein (Lrp) and deoxyadenosine methylase (Dam). " 12/10/2002 - "In the pyelonephritis-associated pili (pap) system, global regulators [catabolite gene activator protein (CAP), leucine-responsive regulatory protein (Lrp), DNA adenine methylase (Dam)] and local regulators (PapI and PapB) control phase switching. "
3.	Starvation 01/01/2008 - "The bacterial leucine-responsive regulatory protein (Lrp) is a global transcriptional regulator that controls the expression of many genes during starvation and the transition to stationary phase. "
4.	Scrapie 01/01/2019 - "We report here that ridA is positively regulated by leucine responsive regulatory protein (Lrp) and leucine antagonizes the activation by Lrp. "
5.	Gastroesophageal Reflux (GERD) 01/01/2019 - "Those differential expressed proteins were mainly involved in cell wall hydrolysis, cell morphological changes, protein synthesis and folding, perception of external stimuli and signal transduction etc., and we observed that germination receptor D (GerD), cell wall hydrolase, transpeptidase, peptidase S1 and two-component regulatory system phoR were significantly up-regulated, but hydrolase NlpC/P60, peptidoglycan glycosyltransferase, spore coat proteins CotX, CotJB and the Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C products) protein were significantly down-regulated in the experiment, which implied the important roles of identified proteins during the spore germination. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Leucine (L-Leucine)
3.	Deoxyribonuclease I (Nickase)
4.	Cyclic AMP Receptor Protein (Catabolite Activator Protein)
5.	Adenine
6.	polyaminopropylbiguanide (PAPB)
7.	2'-deoxyadenosine
8.	Peptidoglycan Glycosyltransferase
9.	Proteins (Proteins, Gene)
10.	Peptidyl Transferases (Peptidyltransferase)