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DNA-Activated Protein Kinase

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A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding protein substrates including the TUMOR SUPPRESSOR PROTEIN P53 and a variety of TRANSCRIPTION FACTORS.

Also Known As:

DNA-Dependent Protein Kinase; DNA-Dependent Protein Serine-Threonine Kinase; DNA Activated Protein Kinase; DNA Dependent Protein Kinase; DNA Dependent Protein Serine Threonine Kinase; Kinase, DNA-Activated Protein; Kinase, DNA-Dependent Protein; Protein Kinase, DNA-Activated; Protein Kinase, DNA-Dependent

Networked: 314 relevant articles (3 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Transferases: 4296
    - Phosphotransferases: 30637
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9706
        Protein-Serine-Threonine Kinases: 1353
        DNA-Activated Protein Kinase: 314
        human PRKDC protein
        mouse Prkdc protein

Experts

1.	Sleckman, Barry P: 4 articles (02/2013 - 11/2009)
2.	Lees-Miller, Susan P: 4 articles (11/2011 - 12/2002)
3.	Matsumoto, Yoshihisa: 4 articles (01/2011 - 08/2004)
4.	Hosoi, Yoshio: 4 articles (01/2009 - 08/2004)
5.	Madhusudan, Srinivasan: 3 articles (12/2014 - 07/2014)
6.	Perry, Christina: 3 articles (12/2014 - 07/2014)
7.	Arora, Arvind: 3 articles (12/2014 - 07/2014)
8.	Chen, Benjamin P C: 3 articles (11/2014 - 01/2009)
9.	Paules, Richard S: 3 articles (01/2014 - 01/2008)
10.	Innes, Cynthia L: 3 articles (01/2014 - 01/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2011 - "Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells." 05/24/2011 - "The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer." 07/15/2004 - "Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis." 12/01/2003 - "DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer." 11/30/2001 - "An enhanced tumor development was observed, however, when the PARP-1 null mutation was introduced into severely compromised immune-deficient mice (a mutation in DNA-dependent protein kinase) or mice lacking other DNA repair or chromosomal guardian molecules, such as p53 or Ku80. "
2.	Ataxia Telangiectasia (Louis Bar Syndrome) 09/01/2013 - "Under these conditions, ataxia-telangiectasia mutated activation and accumulation of DNA-dependent protein kinase, catalytic subunit pS2056 foci suggested an increased number of DSBs processed by nonhomologous end-joining (NHEJ). " 11/01/2003 - "These results did not correlate with radiation-induced apoptosis but did correlate with functional impairment of DNA repair and suppressed expression of several repair-related genes, such as Ku70, DNA-dependent protein kinase, ataxia telangiectasia mutated, and X-ray-sensitive complementation group 4. Normal human fibroblast MRC-9 cells showed no impairment in the repair capability due to Ad-p53 despite the suppression of some repair genes. " 12/01/2001 - "Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase." 09/19/1996 - "The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation." 06/15/2008 - "Prognostic significance of ataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer."
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/01/2009 - "[Correlation of DNA-dependent protein kinase catalytic subunit expression to radiosensitivity of non-small cell lung cancer cell lines]." 11/15/2002 - "The inhibition of DNA-dependent protein kinase activity with antisense-oligodeoxynucleotide (As-ODN) and its consequences for the rejoining of DNA-double-strand breaks (Dsbs) and radiation sensitivity was studied in human non-small cell lung cancer (NSCLC) cell lines. " 10/20/2003 - "To study the expression of catalylic subunit of DNA-dependent protein kinase (DNA-PKcs) in non-small cell lung cancer (NSCLC) and its relationship with apoptosis. " 01/01/2015 - "The TP53-null human non-small cell lung cancer cell line H1299 was used for testing the radiosensitizing effect of NHEJR-related DNA-dependent protein kinase (DNA-PK) inhibitor NU7026, HRR-related Rad51 inhibitor B02, or both to C ion irradiation using colony forming assays. " 02/01/2014 - "To examine the effects of combined blockade of DNA-dependent protein kinase (DNA-PK) and poly(adenosine diphosphate-ribose) polymerase-1 (PARP-1) on accelerated senescence in irradiated H460 and A549 non-small cell lung cancer cells. "
4.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/01/2003 - "Using severe combined immunodeficiency mice defective in DNA-dependent protein kinase catalytic subunit, we examined the role of DNA-dependent protein kinase activity in radioadaptation induced by low dose irradiation. " 12/05/1995 - "In this report, we show that the factor defective in the autosomal recessive severe combined immunodeficiency of Arabian foals is required for (i) V(D)J recombination, (ii) resistance to ionizing radiation, and (iii) DNA-dependent protein kinase activity." 12/05/1995 - "Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity." 02/01/2015 - "DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency." 11/01/2015 - "Defects in DNA cross-link repair 1C (DCLRE1C), protein kinase DNA activated catalytic polypeptide (PRKDC), ligase 4 (LIG4), NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway result in radiation-sensitive severe combined immunodeficiency (SCID). "
5.	Carcinoma (Carcinomatosis) 05/01/2006 - "The main aim of this study was to analyse the expression of the heterodimers Ku70 and Ku80, building regulatory subunits of the DNA-dependent protein kinase in 40 oral carcinomas. " 03/01/2001 - "Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas." 01/01/1999 - "DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity." 12/19/2005 - "Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated." 07/01/2007 - "The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
3.	Phosphotransferases (Kinase)
4.	Phosphatidylinositol 3-Kinases
5.	NVP BEZ235
6.	Proteins (Proteins, Gene)
7.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
8.	Messenger RNA (mRNA)
9.	Cisplatin (Platino)
10.	ataxia telangiectasia mutated protein

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Radiotherapy