ADAM Proteins

A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. They are responsible for the proteolytic cleavage of many transmembrane proteins and the release of their extracellular domain.

Also Known As:

Networked: 24 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Muc-Wierzgoń, Małgorzata: 2 articles (01/2019 - 01/2018)
2.	Nowakowska-Zajdel, Ewa: 2 articles (01/2019 - 01/2018)
3.	Walkiewicz, Katarzyna: 2 articles (01/2019 - 01/2018)
4.	Gül, Ceren: 1 article (04/2022)
5.	Kılıc, Sevilay: 1 article (04/2022)
6.	Şehitoğlu, Hilal: 1 article (04/2022)
7.	Fan, You-Fen: 1 article (01/2022)
8.	Le, Xin: 1 article (01/2022)
9.	Andrade, M V S: 1 article (01/2020)
10.	Bezerra, T G: 1 article (01/2020)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "In the present study, we investigated the role of ADAM proteins in colorectal cancer (CRC) cell migration and invasion focusing on the epigenetic mechanism whereby ADAM transcription is regulated. " 01/01/2019 - "In this article, we present results of study on the role of ADAM proteins in colorectal cancer. " 01/01/2018 - "The role of some ADAM-proteins and activation of the insulin growth factor-related pathway in colorectal cancer."
2.	Neoplasms (Cancer) 01/01/2020 - "ADAM proteins are associated with diseases like cancers. " 07/01/2013 - "The ADAM proteins have also been implicated in various diseases, including cancer. " 12/01/2008 - "ADAM proteins - therapeutic potential in cancer." 12/01/2004 - "ADAM genes have been associated with cancer, with ADAM expression, genomic rearrangements, and, by implication of ADAM proteins in the altered behavior found in tumor cells. " 01/01/2012 - "Both ADAM proteins cleave various substrates, and therefore have been associated with tumorigenesis and tumor progression."
3.	Neoplasm Metastasis (Metastasis) 12/01/2008 - "Emerging evidence has suggested that the ADAM proteins are involved in tumour cell proliferation, in angiogenesis as well as metastasis. " 04/03/2023 - "ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. " 06/15/2004 - "To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9, -10, -12, -15, and -17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. " 10/11/2022 - "However, the most translational advance of this study is to reveal, for the first time, the possibility of reducing metastasis by pharmacological inhibition of ITGA9 with a synthetic peptide simulating a key interaction domain of ADAM proteins, in experimental metastasis models, not only in childhood cancers but also in a breast cancer model." 08/15/2011 - "Oxidative stress plays a role in the regulation of cancer cell metastasis which involves cell invasion and adhesion that could be supported by ADAM proteins through the activities of their metalloprotease and disintegrin domains. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "A number of ADAM proteins have been implicated in the occurrence of breast cancer, including ADAM 9, ADAM12, ADAM15, ADAM17, ADAM22, and ADAM28. " 10/11/2022 - "However, the most translational advance of this study is to reveal, for the first time, the possibility of reducing metastasis by pharmacological inhibition of ITGA9 with a synthetic peptide simulating a key interaction domain of ADAM proteins, in experimental metastasis models, not only in childhood cancers but also in a breast cancer model."
5.	Carcinogenesis 01/01/2012 - "Both ADAM proteins cleave various substrates, and therefore have been associated with tumorigenesis and tumor progression." 08/01/2010 - "In this review, we focus on the contribution of ADAM proteins to HCC tumorigenesis and cancer progression. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Metalloproteases (Metalloproteinases)
3.	Disintegrins
4.	Integrins
5.	ErbB Receptors (EGF Receptor)
6.	Amyloid Precursor Protein Secretases (beta-Secretase)
7.	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	MicroRNAs (MicroRNA)
10.	Biomarkers (Surrogate Marker)