Activating Transcription Factor 1

An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.

Also Known As:

ATF1 Transcription Factor; Activating Transcription Factor-1; Transcription Factor, ATF1

Networked: 53 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic-Leucine Zipper Transcription Factors: 187
      - Activating Transcription Factors: 32
        Activating Transcription Factor 1: 53
        human ATF1 protein
        mouse Atf1 protein
        S pombe atf1 protein
  - DNA-Binding Proteins: 2009
    - Basic-Leucine Zipper Transcription Factors: 187
      - Activating Transcription Factors: 32
        Activating Transcription Factor 1: 53
        human ATF1 protein
        mouse Atf1 protein
        S pombe atf1 protein

Experts

1.	Huang, Guo-Liang: 4 articles (01/2022 - 01/2012)
2.	He, Zhiwei: 3 articles (01/2022 - 12/2016)
3.	Li, Tong: 3 articles (01/2022 - 12/2016)
4.	Lu, Yan: 3 articles (01/2019 - 01/2012)
5.	Bar-Eli, Menashe: 3 articles (12/2008 - 10/2004)
6.	Poremba, Christopher: 3 articles (07/2006 - 05/2002)
7.	Schaefer, Karl-Ludwig: 3 articles (07/2006 - 05/2002)
8.	Wai, Daniel H: 3 articles (07/2006 - 05/2002)
9.	Melnikova, Vladislava O: 2 articles (12/2008 - 07/2008)
10.	Brachwitz, Kristin: 2 articles (07/2006 - 05/2004)

Related Diseases

1.	Hypoxia (Hypoxemia) 08/01/2009 - "The 5' element binds CREB/activating transcription factor 1, and the 3' element is a functional hypoxia-responsive element binding hypoxia-inducible factor 1alpha. " 11/15/1999 - "The protective effects of iron chelators are correlated with their ability to enhance DNA binding of HIF-1 and activating transcription factor 1(ATF-1)/cAMP response element-binding protein (CREB) to the hypoxia response element in cortical cultures and the H19-7 hippocampal neuronal cell line. "
2.	Neoplasms (Cancer) 01/01/2022 - "Studies have revealed an important role of activating transcription factor 1 (ATF1) and phosphorylated ATF1 at Ser63 in tumors. " 01/01/2021 - "Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in children and young adults characterized by fusion of a FET family gene (usually EWSR1, but rarely FUS) to a CREB family transcription factor (ATF1, CREB1, or CREM), and have been variously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. " 06/01/2015 - "Reverse transcription polymerase chain reaction demonstrated Ewing's sarcoma oncogene-activating transcription factor 1 fusion transcripts in the tumor cells. " 01/01/2021 - "The cAMP response element binding protein (CREB) family activating transcription factor 1 (ATF1) and cAMP response element binding protein 1 (CREB1) have been reported in a diverse group of tumors, however, the mechanistic basis for this remains unclear. " 11/01/1997 - "The prototypic soft tissue tumor showing "clear" cytoplasmic features is the so-called clear cell sarcoma or malignant melanoma of soft parts, a tumor characterized by immunophenotypic and ultrastructural melanogenic differentiation and specific cytogenetic and molecular abnormalities, ie, t(12;22)(q13;q12) translocation and Ewing's sarcoma oncogene/activating transcription factor 1 rearrangement. "
3.	Oculocutaneous Albinism (Albinism, Yellow Mutant) 01/01/2015 - "Serum 25(OH)D and SNPs (n = 960) related to genes with relevance for skin pigmentation (tyrosinase [TYR], TYR-related protein 1 [TYRP1], dopachrome tautomerase [DCT], oculocutaneous albinism II [OCA2], two pore segment channel 2 [TPCN2], solute carrier family 24 A4 [SLC24A4], solute carrier family 45 A2 [SLC45A2], agouti signalling peptide [ASIP], cyclic AMP-dependent transcription factor [ATF1], microphthalmia-associated transcription factor [MITF], proopiomelanocortin [POMC], cAMP-dependent protein kinase catalytic subunit beta [PRKACB], cAMP-dependent protein kinase catalytic subunit gamma [PRKACG], cAMP-dependent protein kinase type I-alpha regulatory subunit [PRKAR1A], cAMP-dependent protein kinase type II-alpha regulatory subunit [PRKAR2A], cAMP-dependent protein kinase type II-beta regulatory subunit [PRKAR2B], tubulin beta-3 chain/melanocortin receptor 1 [TUBB3/MC1R], Cadherin-1 [CDH1], catenin beta 1 [CTNNB1], Endothelin 1 [EDN1], endothelin 3 [EDN3], endothelin receptor type B [EDNRB], fibroblast growth factor 2 [FGF2], KIT, KIT ligand [KITLG], nerve growth factor [NGF], interferon regulatory factor 4 [IRF4], exocyst complex component 2 [EXOC2], and tumor protein 53 [TP53]) were analyzed in a cohort of participants of the Ludwigshafen Risk and Cardiovascular Health Study (n = 2970). "
4.	Oculocutaneous albinism type 2 01/01/2015 - "Serum 25(OH)D and SNPs (n = 960) related to genes with relevance for skin pigmentation (tyrosinase [TYR], TYR-related protein 1 [TYRP1], dopachrome tautomerase [DCT], oculocutaneous albinism II [OCA2], two pore segment channel 2 [TPCN2], solute carrier family 24 A4 [SLC24A4], solute carrier family 45 A2 [SLC45A2], agouti signalling peptide [ASIP], cyclic AMP-dependent transcription factor [ATF1], microphthalmia-associated transcription factor [MITF], proopiomelanocortin [POMC], cAMP-dependent protein kinase catalytic subunit beta [PRKACB], cAMP-dependent protein kinase catalytic subunit gamma [PRKACG], cAMP-dependent protein kinase type I-alpha regulatory subunit [PRKAR1A], cAMP-dependent protein kinase type II-alpha regulatory subunit [PRKAR2A], cAMP-dependent protein kinase type II-beta regulatory subunit [PRKAR2B], tubulin beta-3 chain/melanocortin receptor 1 [TUBB3/MC1R], Cadherin-1 [CDH1], catenin beta 1 [CTNNB1], Endothelin 1 [EDN1], endothelin 3 [EDN3], endothelin receptor type B [EDNRB], fibroblast growth factor 2 [FGF2], KIT, KIT ligand [KITLG], nerve growth factor [NGF], interferon regulatory factor 4 [IRF4], exocyst complex component 2 [EXOC2], and tumor protein 53 [TP53]) were analyzed in a cohort of participants of the Ludwigshafen Risk and Cardiovascular Health Study (n = 2970). "
5.	Ewing Sarcoma (Sarcoma, Ewing) 10/01/2022 - "It is characterized by a balanced t(12;22) (q13;q12) chromosomal translocation, resulting in a fusion of the Ewing's sarcoma gene EWSR1 with activating transcription factor 1 (ATF1) to give an oncogene EWSR1-ATF1. " 06/01/2015 - "Reverse transcription polymerase chain reaction demonstrated Ewing's sarcoma oncogene-activating transcription factor 1 fusion transcripts in the tumor cells. " 06/19/2014 - "This sarcoma is defined by t(12;22)(q13;q12) translocation, which leads to the fusion of Ewing sarcoma gene (EWS) to activating transcription factor 1 (ATF1) gene, producing a chimeric EWS-ATF1 fusion gene. " 09/15/2003 - "Clear cell sarcoma (CCS) is associated with the EWS/ATF1 oncogene that is created by chromosomal fusion of the Ewings Sarcoma oncogene (EWS) and the cellular transcription factor ATF1. " 08/08/2023 - "Targeted RNA sequencing revealed Ewing Sarcoma Breakpoint Region 1 (EWSR1)- activating transcription factor 1 (ATF1) fusion. "

Related Drugs and Biologics

1.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
2.	DNA (Deoxyribonucleic Acid)
3.	Iron
4.	Chelating Agents
5.	Proteins (Proteins, Gene)
6.	Cyclic AMP (AMP, Cyclic)
7.	Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit
8.	Microphthalmia-Associated Transcription Factor
9.	beta Catenin
10.	Interferon Regulatory Factors

Related Therapies and Procedures

1.	Therapeutics