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Malignant Fibrous Histiocytoma

Subscribe to New Research on Malignant Fibrous Histiocytoma

The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.

Also Known As:

Histiocytoma, Malignant Fibrous; Malignant Fibrohistiocytic Tumors; Pleomorphic Malignant Fibrous Histiocytoma; Fibrohistiocytic Tumor, Malignant; Fibrohistiocytic Tumors, Malignant; Fibrous Histiocytoma, Malignant; Fibrous Histiocytomas, Malignant; Histiocytomas, Malignant Fibrous; Malignant Fibrohistiocytic Tumor; Malignant Fibrous Histiocytomas; Tumor, Malignant Fibrohistiocytic; Tumors, Malignant Fibrohistiocytic

Networked: 739 relevant articles (19 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Sarcoma: 14738
      - Malignant Fibrous Histiocytoma: 739
    - Connective Tissue Neoplasms: 6
      - Fibrous Tissue Neoplasms
        Histiocytoma: 90
        Malignant Fibrous Histiocytoma: 739

Related Diseases

1.	Neoplasms (Cancer)
2.	Osteosarcoma (Osteogenic Sarcoma)
3.	Sarcoma (Soft Tissue Sarcoma)
4.	Rhabdomyosarcoma
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Kawamoto, Teruya: 14 articles (08/2014 - 05/2003)
2.	Akisue, Toshihiro: 14 articles (08/2014 - 05/2003)
3.	Kurosaka, Masahiro: 13 articles (08/2014 - 05/2003)
4.	Yamamoto, Tetsuji: 12 articles (06/2014 - 05/2003)
5.	Hitora, Toshiaki: 11 articles (06/2014 - 05/2003)
6.	Nakatani, Tetsuya: 8 articles (09/2004 - 05/2003)
7.	Marui, Takashi: 8 articles (09/2004 - 05/2003)
8.	Fujita, Ikuo: 8 articles (09/2004 - 05/2003)
9.	Matsumoto, Keiji: 7 articles (09/2004 - 05/2003)
10.	Nagira, Keiko: 7 articles (09/2004 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Malignant Fibrous Histiocytoma:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/01/1988 - "Two cases of unresectable retroperitoneal malignant fibrous histiocytoma (MFH) achieving a prolonged complete remission by a combination of chemotherapy (adriamycin plus cyclophosphamide) and abdominal irradiation are reported. " 04/01/1986 - "In a young woman with multiple malignant fibrous histiocytoma of bone and soft tissue with a rapidly progressive course, long-term chemotherapy with prednisone and cyclophosphamide resulted in a complete remission still lasting after an 11-year follow-up." 09/01/1985 - "With the use of human LDH as a marker, growth and remission of four human osteosarcomas (KOS-1, KOS-2, KOS-3, OST) and a malignant fibrous histiocytoma (KMF) transplanted into nude mice were monitored during chemotherapies (Adriamycin [doxorubicin], cisplatin, mitomycin C, cyclophosphamide and vincristine). "
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 12/01/1987 - "The malignancy index, furthermore, was compatible with the histological evaluation of the effectiveness of chemotherapy in an adriamycin-treated malignant fibrous histiocytoma." 01/01/1990 - "Intra-arterial cisplatinum and intravenous adriamycin in the treatment of osteosarcoma and malignant fibrous histiocytoma of bone: early surgical and clinical results." 01/01/2015 - "Doxorubicin is used as the standard treatment for cancers that express the highest levels of CREB3L1 such as osteosarcoma and malignant fibrous histiocytoma but is not generally used to treat those that express the lowest levels of CREB3L1 such as RCC. " 12/01/1998 - "Between October 1979 and December 1995, 15 patients with a median age of 45 (range 16-66) and a resected primary cardiac sarcoma [angiosarcoma (six), malignant fibrous histiocytoma (three), leiomyosarcoma (two), rhabdomyosarcoma (two), liposarcoma (one) and synoviosarcoma (one)] received a doxorubicin-containing regimen within 6 weeks of surgery. " 11/01/1997 - "In vivo tumouricidal effect of T lymphocytes activated by liposomes containing adriamycin on chemically-induced rat malignant fibrous histiocytoma."
3.	Dermatofibrosarcoma protuberansIBA 02/01/2014 - "Dermatofibrosarcoma protuberans (DFSP) is a malignant fibrohistiocytic tumor that may be difficult to distinguish from DF. " 06/01/2008 - "3D-Histological evaluation of surgery in dermatofibrosarcoma protuberans and malignant fibrous histiocytoma: differences in growth patterns and outcome." 03/01/1988 - "Biopsy specimens from the recurrences revealed a gradual change in appearance from dermatofibrosarcoma protuberans to malignant fibrous histiocytoma." 05/01/1987 - "These results are discussed in the context of the published findings in other so-called fibrohistiocytic tumours including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma. " 11/01/2010 - "To date, studies analysing HLA class I and class II expression levels in malignant fibrous histiocytomas, fibrosarcomas and dermatofibrosarcoma protuberans are limited. "
4.	Cisplatin (Platino)FDA LinkGeneric 04/01/2007 - "[A case of retroperitoneal malignant fibrous histiocytoma with marked response to concurrent cisplatin and radiation therapy: a case report]." 04/01/2007 - "Potential osteogenic differentiation of cisplatin-resistant rat malignant fibrous histiocytoma-derived cell lines." 08/01/1996 - "The histogenesis of malignant fibrous histiocytoma (MFH) was studied using cisplatin (CDDP)-resistant MT-R8 and MT-R9 cells derived from cloned undifferentiated MT-8 and fibrohistiocytic MT-9 cells, respectively, which had been established from transplantable rat MFH. " 08/01/1996 - "Phenotypic modulation in cisplatin-resistant cloned cells derived from transplantable rat malignant fibrous histiocytoma." 08/01/1990 - "A cis-diamminedichloroplatinum (CDDP)-selected cell line (MT-R10) was induced by continuous exposure of an in vitro passaged cell line (MT-P) established from a transplantable rat malignant fibrous histiocytoma (MFH-MT) to CDDP. "
5.	Monoclonal AntibodiesIBA 09/01/1989 - "We assessed the osteoclast-like giant cells in a giant cell-rich variant of malignant fibrous histiocytoma (MFH) for characteristics which are specific for osteoclasts, including excavation of bone and binding of osteoclast-specific monoclonal antibodies. " 08/01/1986 - "Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. " 10/01/1994 - "By immunohistochemistry using anti-rat macrophage monoclonal antibodies RM-1, ED1, ED2, ED3, TRPM-3, and Ki-M2R, we studied transplanted rat tumors of 9L (rat gliosarcoma), Ad-2 (rat mammary carcinoma), and MT-P (rat malignant fibrous histiocytoma) cell lines to examine the distribution pattern of macrophages within and around the tumors. " 01/01/1988 - "In this study fresh frozen tissue samples of benign osseous tumors (five non-osteogenic fibromas, one fibrous dysplasia, one chondromyxoidfibroma), tumors of uncertain biological behaviour (eight cases of histiocytosis X, two giant-cell tumors), and of malignant intraosseous tumors (two malignant fibrous histiocytomas, two malignant histiocytosis, four osteosarcomas, one chondrosarcoma and two Ewing sarcomas) were studied with a panel of monoclonal antibodies reactive with monocyte/macrophages and various types of dendritic cells. " 05/01/1989 - "The neoplastic pleomorphic cells in malignant fibrous histiocytomas (MFHs) usually had strongly positive results for AAT, whereas only entrapped histocytes had positive results for lysozyme and for two monoclonal antibodies to histomonocytic cells. "
6.	Muramidase (Lysozyme)IBA 03/01/1987 - "Lysozyme could be demonstrated in the cells of the one proven malignant fibrous histiocytoma; all malignant epithelial cells were negative. " 11/01/1982 - "Some malignant fibrous histiocytomas showed scattered lysozyme positive neoplastic cells, indicating their probable histiocytic origin or differentiation. " 11/01/1982 - "Cells positive for lysozyme were found only in 13 out of 100 cases of dermatofibroma, one out of 4 cases of xanthogranuloma and 8 out of 33 cases of malignant fibrous histiocytoma. " 05/01/1994 - "The results of lysozyme and CD68 stainings were interesting especially in malignant fibrous histiocytoma (MFH), fibrosarcoma and osteosarcoma. " 05/01/1989 - "The neoplastic pleomorphic cells in malignant fibrous histiocytomas (MFHs) usually had strongly positive results for AAT, whereas only entrapped histocytes had positive results for lysozyme and for two monoclonal antibodies to histomonocytic cells. "
7.	Factor XIIIaIBA 07/01/1988 - "Factor XIIIa and the classic histiocytic markers in malignant fibrous histiocytoma: a comparative immunohistochemical study." 01/01/2005 - "Histiocyte-like cells expressing factor XIIIa do not belong to the neoplastic cell population in malignant fibrous histiocytoma." 01/01/1991 - "All cases of malignant fibrous histiocytoma showed positive staining for factor XIIIa, alpha-1-antitrypsin and alpha-1-antichymotrypsin. " 08/01/2004 - "Differentiation from atypical dermatofibroma and dermatomyofibroma, as well as from malignant fibrous histiocytoma, whose prognosis is usually much less favorable, can be improved by immunostaining for CD 34 and Factor XIIIa. " 01/01/1997 - "An unusual soft tissue tumor with features of angiomatoid malignant fibrous histiocytoma composed of bimodal CD34 and factor XIIIa positive dendritic cell subsets. "
8.	MethylcholanthreneIBA 02/01/1990 - "In murine sarcomas induced by 20-methylcholanthrene, histological features of malignant fibrous histiocytoma (MFH) as well as rhabdomyosarcoma were found in the same tumour both at light microscopy and at ultrastructural level. " 01/01/1988 - "In the study presented here we used methylcholanthrene induced sarcomas (rhabdomyosarcomas and undifferentiated sarcomas in part showing the picture of storiform/pleomorphic malignant fibrous histiocytomas) which were produced in NMRI mice and examined (1) whether or not metastasis formation could be triggered or enhanced by repeated inadequate tumor surgery in these animals, and (2) the efficacy of the same surgical procedure following xenotransplantation of the tumors into nude mice. "
9.	Vincristine (Oncovin)FDA LinkGeneric 02/01/2000 - "[A case of malignant fibrous histiocytoma of mesocolon successfully resected after combined chemotherapy with epirubicin, CDDP and vincristine]." 09/01/1985 - "With the use of human LDH as a marker, growth and remission of four human osteosarcomas (KOS-1, KOS-2, KOS-3, OST) and a malignant fibrous histiocytoma (KMF) transplanted into nude mice were monitored during chemotherapies (Adriamycin [doxorubicin], cisplatin, mitomycin C, cyclophosphamide and vincristine). "
10.	Caffeine (No Doz)FDA LinkGeneric 12/01/2000 - "Caffeine potentiated chemotherapy was effective in minimizing the extent of tumor excision, in this case of high-grade malignant fibrous histiocytoma representing transformation from a benign giant cell tumor." 04/01/1990 - "[Intra-arterial infusion of cisplatin and caffeine for a recurrent malignant fibrous histiocytoma]." 04/01/1990 - "We treated a 43-year-old man with recurrent malignant fibrous histiocytoma in right distal femur with intra-arterial infusion of cisplatin and caffeine 5 years after wide excision and chemotherapy. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/1986 - "Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. " 09/01/1978 - "Prolonged complete remission in malignant fibrous histiocytoma treated with chemotherapy." 04/01/1990 - "[Remission of a malignant fibrous histiocytoma treated with combined radio-chemotherapy: follow-up using MRT]." 05/01/1980 - "Recurrence rates of approximately 44 per cent of malignant fibrous histiocytoma in other sites are not improved by radiation or chemotherapy as adjuvants or primary means of treatment. " 12/01/1987 - "Nuclear magnetic resonance studies on malignant fibrous histiocytoma--evaluation of the effectiveness of chemotherapy in anticancer drug."
2.	Homologous Transplantation (Allograft) 07/01/2015 - "All cases of osteoarticular allograft reconstruction with or without the S-K procedure following resection of distal radial tumours (giant-cell tumour in 13, desmoplastic fibroma in two, osteosarcoma in one and malignant fibrous histiocytoma in one) performed from 2000 to 2009 were evaluated by clinical and radiologic examinations; the complications, functional outcomes and Musculoskeletal Tumor Society (MSTS) score were recorded. " 01/01/2001 - "The diagnoses were: Ewing's sarcoma 7, osteosarcoma 4, chondrosarcoma 1, and malignant fibrous histiocytoma 1. No megaprostheses or massive allografts were used for reconstruction. " 01/01/1995 - "This study analysed the influence of several factors affecting the consolidation time of 83 massive bone allografts in 79 patients with malignant bone tumours: osteosarcoma 57; Ewing's sarcoma 8; malignant fibrous histiocytoma 3; chondrosarcoma 4; fibrosarcoma 5; and giant cell tumours 2. The mean age of the patients was 19 years and the mean length of the allografts was 18 cm. The minimum follow up was for 12 months. " 02/01/1994 - "From 1987 to 1991, 26 patients with malignant bone tumors (osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma) in the diaphysis or metaphysis of long bones have been treated by chemotherapy, radiotherapy and intercalary bone allograft replacement after resection. " 04/01/2007 - "The diagnosis was conventional osteosarcoma in 16 patients, parosteal osteosarcoma in two patients, chondrosarcoma in two patients, leiomyosarcoma in two patients, failed allograft in two patients and one patient each of periosteal osteosarcoma, Ewing's sarcoma, Gorham's disease, synovial sarcoma, malignant fibrous histiocytoma, metastatic renal cell carcinoma, and prosthetic loosening. "
3.	Heterologous Transplantation (Xenotransplantation) 01/01/1996 - "Serial growth of human malignant fibrous histiocytoma xenografts in immunodeficient mice." 11/01/1996 - "Structure, growth and cell proliferation of human osteosarcoma and malignant fibrous histiocytoma xenografts in serial transplantation in nude mice." 04/01/1982 - "Unusual intranuclear inclusions in malignant fibrous histiocytoma: presence in primary tumor, metastases, and xenografts." 10/01/1990 - "From a panel of 48 human soft tissue sarcomas growing as permanent xenografts, 10 tumor lines (five leiomyosarcomas, three malignant fibrous histiocytomas, two neurofibrosarcomas) have been selected to determine the radiation response to photons and fast neutrons. " 01/01/1988 - "In the study presented here we used methylcholanthrene induced sarcomas (rhabdomyosarcomas and undifferentiated sarcomas in part showing the picture of storiform/pleomorphic malignant fibrous histiocytomas) which were produced in NMRI mice and examined (1) whether or not metastasis formation could be triggered or enhanced by repeated inadequate tumor surgery in these animals, and (2) the efficacy of the same surgical procedure following xenotransplantation of the tumors into nude mice. "
4.	Amputation 03/01/1988 - "A 79-year-old woman required amputation of her left leg for the control of a rapidly growing malignant fibrous histiocytoma. " 01/01/1998 - "These results show that a high percentage of patients with malignant fibrous histiocytoma of the extremities can be cured with neoadjuvant chemotherapy and that for most of them it is possible to avoid amputation." 03/01/1989 - "One patient with malignant fibrous histiocytoma required amputation at the fourth and fifth carpometacarpal joints, one patient with extraskeletal myxoid chondrosarcoma amputation in the proximal third of the forearm. " 12/01/1988 - "Between January, 1974 and July, 1985 66 patients with non-metastatic malignant fibrous histiocytoma (MFH) of bone in the estremities were surgically treated with amputation (34 cases) or resection (32 cases) according to the extension of the tumor. " 01/01/1984 - "One patient developed malignant fibrous histiocytoma in an amputation site, and the other patient developed it in a previous hernioplasty scar. "
5.	Combination Drug Therapy (Combination Chemotherapy) 06/01/1984 - "A patient with metastatic malignant fibrous histiocytoma (MFH) achieved a complete remission with polychemotherapy lasting 42+ months. " 06/01/1984 - "Prolonged remission of metastatic malignant fibrous histiocytoma induced by combination chemotherapy." 07/01/1993 - "Considering the difficulty of medical treatment for malignant fibrous histiocytoma, this case suggests that combination chemotherapy of Carboplatin and Etoposide is valuable. " 07/01/1993 - "For metastatic lung region, a 82-year-old woman with malignant fibrous histiocytoma was successfully treated with combination chemotherapy of Carboplatin and Etoposide. " 07/01/1993 - "[A combination chemotherapy of carboplatin and etoposide for malignant fibrous histiocytoma with marked effect on the metastatic lung region]."