Malignant Fibrous Histiocytoma

The most commonly diagnosed soft tissue sarcoma. It is a neoplasm with a fibrohistiocytic appearance found chiefly in later adult life, with peak incidence in the 7th decade.
Also Known As:
Histiocytoma, Malignant Fibrous; Malignant Fibrohistiocytic Tumors; Pleomorphic Malignant Fibrous Histiocytoma; Fibrohistiocytic Tumor, Malignant; Fibrohistiocytic Tumors, Malignant; Fibrous Histiocytoma, Malignant; Fibrous Histiocytomas, Malignant; Histiocytomas, Malignant Fibrous; Malignant Fibrohistiocytic Tumor; Malignant Fibrous Histiocytomas; Tumor, Malignant Fibrohistiocytic; Tumors, Malignant Fibrohistiocytic
Networked: 739 relevant articles (19 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Osteosarcoma (Osteogenic Sarcoma)
3. Sarcoma (Soft Tissue Sarcoma)
4. Rhabdomyosarcoma
5. Neoplasm Metastasis (Metastasis)


1. Kawamoto, Teruya: 14 articles (08/2014 - 05/2003)
2. Akisue, Toshihiro: 14 articles (08/2014 - 05/2003)
3. Kurosaka, Masahiro: 13 articles (08/2014 - 05/2003)
4. Yamamoto, Tetsuji: 12 articles (06/2014 - 05/2003)
5. Hitora, Toshiaki: 11 articles (06/2014 - 05/2003)
6. Nakatani, Tetsuya: 8 articles (09/2004 - 05/2003)
7. Marui, Takashi: 8 articles (09/2004 - 05/2003)
8. Fujita, Ikuo: 8 articles (09/2004 - 05/2003)
9. Matsumoto, Keiji: 7 articles (09/2004 - 05/2003)
10. Nagira, Keiko: 7 articles (09/2004 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Malignant Fibrous Histiocytoma:
1. Cyclophosphamide (Cytoxan)FDA LinkGeneric
2. Doxorubicin (Adriamycin)FDA LinkGeneric
3. Dermatofibrosarcoma protuberansIBA
4. Cisplatin (Platino)FDA LinkGeneric
5. Monoclonal AntibodiesIBA
09/01/1989 - "We assessed the osteoclast-like giant cells in a giant cell-rich variant of malignant fibrous histiocytoma (MFH) for characteristics which are specific for osteoclasts, including excavation of bone and binding of osteoclast-specific monoclonal antibodies. "
08/01/1986 - "Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. "
10/01/1994 - "By immunohistochemistry using anti-rat macrophage monoclonal antibodies RM-1, ED1, ED2, ED3, TRPM-3, and Ki-M2R, we studied transplanted rat tumors of 9L (rat gliosarcoma), Ad-2 (rat mammary carcinoma), and MT-P (rat malignant fibrous histiocytoma) cell lines to examine the distribution pattern of macrophages within and around the tumors. "
01/01/1988 - "In this study fresh frozen tissue samples of benign osseous tumors (five non-osteogenic fibromas, one fibrous dysplasia, one chondromyxoidfibroma), tumors of uncertain biological behaviour (eight cases of histiocytosis X, two giant-cell tumors), and of malignant intraosseous tumors (two malignant fibrous histiocytomas, two malignant histiocytosis, four osteosarcomas, one chondrosarcoma and two Ewing sarcomas) were studied with a panel of monoclonal antibodies reactive with monocyte/macrophages and various types of dendritic cells. "
05/01/1989 - "The neoplastic pleomorphic cells in malignant fibrous histiocytomas (MFHs) usually had strongly positive results for AAT, whereas only entrapped histocytes had positive results for lysozyme and for two monoclonal antibodies to histomonocytic cells. "
6. Muramidase (Lysozyme)IBA
7. Factor XIIIaIBA
8. MethylcholanthreneIBA
9. Vincristine (Oncovin)FDA LinkGeneric
10. Caffeine (No Doz)FDA LinkGeneric

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Homologous Transplantation (Allograft)
07/01/2015 - "All cases of osteoarticular allograft reconstruction with or without the S-K procedure following resection of distal radial tumours (giant-cell tumour in 13, desmoplastic fibroma in two, osteosarcoma in one and malignant fibrous histiocytoma in one) performed from 2000 to 2009 were evaluated by clinical and radiologic examinations; the complications, functional outcomes and Musculoskeletal Tumor Society (MSTS) score were recorded. "
01/01/2001 - "The diagnoses were: Ewing's sarcoma 7, osteosarcoma 4, chondrosarcoma 1, and malignant fibrous histiocytoma 1. No megaprostheses or massive allografts were used for reconstruction. "
01/01/1995 - "This study analysed the influence of several factors affecting the consolidation time of 83 massive bone allografts in 79 patients with malignant bone tumours: osteosarcoma 57; Ewing's sarcoma 8; malignant fibrous histiocytoma 3; chondrosarcoma 4; fibrosarcoma 5; and giant cell tumours 2. The mean age of the patients was 19 years and the mean length of the allografts was 18 cm. The minimum follow up was for 12 months. "
02/01/1994 - "From 1987 to 1991, 26 patients with malignant bone tumors (osteosarcoma, Ewing's sarcoma, chondrosarcoma and malignant fibrous histiocytoma) in the diaphysis or metaphysis of long bones have been treated by chemotherapy, radiotherapy and intercalary bone allograft replacement after resection. "
04/01/2007 - "The diagnosis was conventional osteosarcoma in 16 patients, parosteal osteosarcoma in two patients, chondrosarcoma in two patients, leiomyosarcoma in two patients, failed allograft in two patients and one patient each of periosteal osteosarcoma, Ewing's sarcoma, Gorham's disease, synovial sarcoma, malignant fibrous histiocytoma, metastatic renal cell carcinoma, and prosthetic loosening. "
3. Heterologous Transplantation (Xenotransplantation)
4. Amputation
5. Combination Drug Therapy (Combination Chemotherapy)