KCNQ3 Potassium Channel

A very slow opening and closing voltage-gated potassium channel that is expressed in NEURONS and is closely related to KCNQ2 POTASSIUM CHANNEL. It is commonly mutated in BENIGN FAMILIAL NEONATAL CONVULSIONS.

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ambrosino, Paolo: 1 article (03/2015)
2.	De Maria, Michela: 1 article (03/2015)
3.	Miceli, Francesco: 1 article (03/2015)
4.	Migliore, Michele: 1 article (03/2015)
5.	Migliore, Rosanna: 1 article (03/2015)
6.	Soldovieri, Maria Virginia: 1 article (03/2015)
7.	Taglialatela, Maurizio: 1 article (03/2015)
8.	Hirose, Shinichi: 1 article (03/2008)
9.	Nakamura, Yuki: 1 article (03/2008)
10.	Shioya, Takao: 1 article (03/2008)

Related Diseases

1.	Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions) 05/01/2007 - "Human mutations of KCNQ2 and KCNQ3 potassium channel genes result in reduction or loss of channel activity and cause benign familial neonatal convulsions (BFNCs). " 12/01/2003 - "KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum." 12/17/1998 - "Potassium channels are important regulators of electrical signalling, and benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, is caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. "
2.	Epilepsy (Aura) 03/01/2008 - "Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy." 12/17/1998 - "Potassium channels are important regulators of electrical signalling, and benign familial neonatal convulsions (BFNC), an autosomal dominant epilepsy of infancy, is caused by mutations in the KCNQ2 or the KCNQ3 potassium channel genes. "
3.	Seizures (Absence Seizure) 11/01/2023 - "To evaluate the efficacy and safety of XEN1101, a novel small-molecule selective Kv7.2/Kv7.3 potassium channel opener, in the treatment of focal-onset seizures (FOSs). "
4.	Brain Diseases (Brain Disorder) 03/04/2015 - "Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits."
5.	Epileptic Syndromes 01/01/2005 - "In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated with an inherited epilepsy syndrome. "

Related Drugs and Biologics

1.	Potassium Channels (Potassium Channel)
2.	XEN1101