KCNQ Potassium Channels

A family of delayed rectifier voltage-gated potassium channels that share homology with their founding member, KCNQ1 PROTEIN. KCNQ potassium channels have been implicated in a variety of diseases including LONG QT SYNDROME; DEAFNESS; and EPILEPSY.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cheng, Jun: 1 article (01/2018)
2.	Fu, Xiaodong: 1 article (01/2018)
3.	Wei, Xiaohong: 1 article (01/2018)
4.	Wen, Jing: 1 article (01/2018)
5.	Yin, Benlan: 1 article (01/2018)
6.	Zhang, Yujiao: 1 article (01/2018)
7.	Bøtker, Hans Erik: 1 article (04/2016)
8.	Hedegaard, Elise R: 1 article (04/2016)
9.	Jespersen, Nichlas R: 1 article (04/2016)
10.	Johnsen, Jacob: 1 article (04/2016)

Related Diseases

1.	Epilepsy (Aura) 09/01/2002 - "These studies may help understand the pathophysiology of human epilepsies and represent the first step towards the discovery of new therapeutic targets, as exemplified in the case of the KCNQ potassium channels." 05/21/2013 - "Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels." 09/01/2008 - "As a result of genetic and functional investigations, not only will the pathophysiology of epilepsy be better understood, but newly discovered genes and pathophysiological pathways may also determine novel targets for pharmacotherapy, as has been shown for the anticonvulsant drug retigabine, which enhances the activity of neuronal KCNQ potassium channels."
2.	Channelopathies 01/01/2001 - "On the basis of genetic and electrophysiologic studies of the channelopathies, novel therapeutic strategies can be developed, as has been shown recently for the antiepileptic drug retigabine activating neuronal KCNQ potassium channels."
3.	Stroke (Strokes) 02/04/2015 - "Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury."
4.	Pre-Eclampsia (Preeclampsia) 01/01/2018 - "The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia."
5.	Nervous System Diseases (Neurological Disorders) 11/01/2006 - "Mutations in neuronal Kv7 (KCNQ) potassium channels can cause episodic neurological disorders. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	ezogabine (retigabine)
3.	Phosphatidylinositols (Phosphatidylinositol)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)