X-Linked Inhibitor of Apoptosis Protein

An inhibitor of apoptosis protein that is translated by a rare cap-independent mechanism. It blocks caspase-mediated cellular destruction by inhibiting CASPASE 3; CASPASE 7; and CASPASE 9.

Also Known As:

Networked: 225 relevant articles (9 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zou, Bing: 7 articles (10/2012 - 03/2006)
2.	Wong, Benjamin C Y: 6 articles (09/2009 - 03/2006)
3.	Li, Jingxia: 5 articles (08/2014 - 05/2011)
4.	Huang, Chuanshu: 5 articles (08/2014 - 05/2011)
5.	Qiao, Liang: 5 articles (09/2009 - 06/2008)
6.	Wang, Jide: 5 articles (09/2009 - 03/2006)
7.	Tsang, Benjamin K: 4 articles (08/2013 - 05/2002)
8.	Zhang, Dongyun: 4 articles (07/2013 - 05/2011)
9.	Devi, Gayathri R: 4 articles (01/2013 - 06/2004)
10.	Asselin, Eric: 4 articles (12/2011 - 08/2008)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2010 - "Most importantly, multivariate analysis also showed statistically significant worse outcomes for patients with tumors exhibiting X-linked inhibitor of apoptosis protein expression of at least 50% compared with those with X-linked inhibitor of apoptosis protein expression less than 50%. " 08/30/2014 - "These studies identified a new function of XIAP protein in cellular nucleus is to regulate E2F1 transcriptional activity by binding with E2F1 in cancer cells. " 03/01/2008 - "And it was observed in previous studies that high levels of X-linked inhibitor of apoptosis protein (XIAP) were related to resistance to chemotherapeutics in many cancer cell lines. " 01/01/2015 - "X-linked inhibitor of apoptosis protein (XIAP) associated factor 1 (XAF1) exhibits aberrantly low or absent expression in various human malignancies, closely associated with anti-apoptosis and overgrowth of cancer cells. " 10/01/2014 - "The X-linked inhibitor of apoptosis protein (XIAP) is a potent caspase inhibitor, best known for its anti-apoptotic function in cancer. "
2.	Prostatic Neoplasms (Prostate Cancer) 06/01/2011 - "In conclusion, the present study indicates that the DATS-induced apoptosis in prostate cancer cells is mediated in part by suppression of XIAP protein expression, and that XIAP represents a viable biomarker of DATS response for future clinical investigations." 05/01/2010 - "Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy." 10/15/2007 - "Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence." 06/01/2004 - "In this study, we identified the critical role of X-linked inhibitor of apoptosis protein (XIAP), a potent antiapoptotic factor, in conferring chemotherapy resistance in an androgen-insensitive DU145 human prostate cancer cell line. " 06/01/2004 - "X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells."
3.	Leukemia 02/01/2008 - "[Effect of (-)-epigallocatechin-3-gallate and 5-AZA-CdR on expression of X-linked inhibitor of apoptosis protein-associated factor 1 in human leukemia HL-60 and K562 cells]." 05/15/2005 - "X-linked inhibitor of apoptosis protein (XIAP) antagonist N-[(5R)-6-[(anilinocarbonyl)amino]-5-((anilinocarbonyl){[(2R)-1-(4-cyclohexylbutyl)pyrrolidin-2-yl]methyl}amino)hexyl]-N-methyl-N'-phenylurea (1396-12), but not a structurally related control compound, induced apoptosis of primary leukemia samples with a lethal dose (LD50) of less than 10 microM in 16 of 27 (60%) samples. " 05/01/2000 - "Altogether, these findings show that IAPs are widely but differentially expressed in human cancers and leukemias and suggest that higher XIAP protein levels may have adverse prognostic significance for patients with AML." 02/01/2008 - "To study the expression of X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (Xaf1) in human leukemia HL-60 and K562 cells treated with interferon alpha (INFalpha) and the demethylating agent 5-AZA-CdR, and observe the synergetic antitumor effect of Xaf1 inducer and (-)-epigallocatechin-3-gallate (EGCG). " 08/01/2006 - "[Expression and significance of X-linked inhibitor of apoptosis protein and its antagonized proteins in acute leukemia]."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 04/18/2013 - "To investigate the effect on cell proliferation and chemosensitivity of human pancreatic cancer cells Panc-1 after X-linked inhibitor of apoptosis protein (XIAP) and Survivin are inhibited simultaneously, and to compare it with the separate gene suppression strategy by which expression of XIAP or Survivin is inhibited respectively. " 04/18/2013 - "[X-linked inhibitor of apoptosis protein (XIAP) and Survivin suppression on human pancreatic cancer cells Panc-1 proliferation and chemosensitivety]." 09/01/2012 - "To investigate the simultaneous inhibition of X-linked inhibitor of apoptosis protein (XIAP) and survivin expression on epithelial-mesenchymal transition (EMT) and invasiion of pancreatic cancer cells Panc-1, and its mechanism. " 06/21/2012 - "Targeting X-linked inhibitor of apoptosis protein inhibits pancreatic cancer cell growth through p-Akt depletion." 03/01/2007 - "Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein."
5.	Melanoma (Melanoma, Malignant) 09/01/2010 - "Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy." 09/01/2010 - "The aim of this study was to determine the prognostic and therapeutic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma through correlation of XIAP expression with disease stage, RAS/RAF mutational status, clinical outcome, and susceptibility to endoplasmic reticulum (ER) stress-induced cell death. " 03/01/2011 - "Targeting x-linked inhibitor of apoptosis protein for melanoma therapy: the need for more homogeneous samples and the importance of cell lines." 09/01/2010 - "In this issue, Hiscutt et al. report on the prognostic significance of X-linked inhibitor of apoptosis protein (XIAP) in melanoma. " 09/01/2010 - "X-linked inhibitor of apoptosis protein as a therapeutic target in metastatic melanoma."

Related Drugs and Biologics

1.	Inhibitor of Apoptosis Proteins
2.	Messenger RNA (mRNA)
3.	Caspase 3 (Caspase-3)
4.	Staphylococcal Protein A (A, Protein)
5.	Quercetin
6.	Protons (Proton)
7.	Etoposide (VP 16)
8.	gemcitabine
9.	Proteins (Proteins, Gene)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Carotid Endarterectomy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Therapeutics
5.	Castration