Classical Pathway Complement C3 Convertase

A serine protease that cleaves multiple COMPLEMENT 3 into COMPLEMENT 3A (anaphylatoxin) and COMPLEMENT 3B in the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It is a complex of COMPLEMENT 4B and COMPLEMENT 2A (C4b2a).

Also Known As:

Networked: 10 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Zhaojun: 1 article (04/2022)
2.	Wang, Jing: 1 article (04/2022)
3.	Wu, Haijie: 1 article (04/2022)
4.	Zhang, Sen: 1 article (04/2022)
5.	Zhang, Ying: 1 article (04/2022)
6.	Elvington, M: 1 article (03/2015)
7.	Schepp-Berglind, J: 1 article (03/2015)
8.	Tomlinson, S: 1 article (03/2015)
9.	Atkinson, John P: 1 article (12/2012)
10.	Casper, James T: 1 article (12/2012)

Related Diseases

1.	Infections 03/01/2015 - "Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis. "
2.	Colitis 03/01/2015 - "Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis. "
3.	Hemolysis 09/08/2009 - "We characterize the catalytic activity of C2 against C3 and short paranitroanilide peptide substrates, and identify potent small molecule inhibitors of C2 that also inhibit classical pathway C3 convertase, MAC formation, and hemolysis of sensitized sheep erythrocytes. " 04/24/2022 - "Most surprising finding in the current study was that esculetin could inhibit the complement activation both in classical and alternative pathway using in vitro hemolysis assay, further enzyme assay suggested that esculetin blocked the C3 convertase (C4b2a) to exert this inhibitory capability. " 09/01/1999 - "The principle of this assay is based on the hemolysis of sensitized sheep erythrocytes (EA) by complement components in two sera: C42 (the classical pathway C3 convertase) is generated on EA by C1, C4 and C2 in the first serum, followed by a second reaction leading to hemolysis by C3-C9 supplied by the addition of the second serum in the presence of EDTA. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 10/01/1983 - "Relative importance of C4 binding protein in the modulation of the classical pathway C3 convertase in patients with systemic lupus erythematosus." 07/01/1980 - "Stabilization of the classical pathway C3 convertase C42, by a factor F-42, isolated from serum of patients with systemic lupus erythematosus." 01/01/1988 - "Nephritic factor of the classical complement pathway (C4NeF) is an IgG antibody which stabilizes the C3 convertase (C4b2a) and has been detected in sera from patients with systemic lupus erythematosus (SLE) and acute postinfectious glomerulonephritis. " 06/01/1984 - "Heterogeneity, polypeptide chain composition and antigenic reactivity of autoantibodies (F-42) that are directed against the classical pathway C3 convertase of complement and isolated from sera of patients with systemic lupus erythematosus."
5.	Amyloid Plaque 12/01/1997 - "In order to test this hypothesis, we sought to determine if a major peptide component of amyloid plaques, A beta 1-42, supports the formation of the classical pathway C3 convertase. "

Related Drugs and Biologics

1.	Mannose-Binding Lectin (Mannan-Binding Lectin)
2.	Sodium
3.	Opsonin Proteins (Opsonins)
4.	Dextrans (Dextran)
5.	Enzymes
6.	esculetin
7.	Peptides (Polypeptides)
8.	Complement System Proteins (Complement)
9.	Autoantibodies
10.	complement 4 nephritic factor