HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Proto-Oncogene Proteins c-vav

Proteins that are guanine nucleotide exchange factors for RHO GTPASES. They contain pleckstrin homology and SH2 domains, through which they function as signal transducing adaptor proteins.
Also Known As:
Proto-Oncogene Protein c-vav; Proto-Oncogene Protein vav; Proto-Oncogene Protein vav1; vav Guanine-Nucleotide Exchange Factor; Proteins c-vav, Proto-Oncogene; Proto Oncogene Protein c vav; Proto Oncogene Protein vav; Proto Oncogene Protein vav1; Proto Oncogene Proteins c vav; Proto-Oncogene Protein, vav; c vav Protein; c-vav, Proto-Oncogene Protein; c-vav, Proto-Oncogene Proteins; vav Guanine Nucleotide Exchange Factor; vav Proto Oncogene Protein; vav, Proto-Oncogene Protein; vav1, Proto-Oncogene Protein; c-vav Protein; vav Proto-Oncogene Protein
Networked: 12 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Cheng, Bin: 1 article (01/2022)
2. Deng, Miao: 1 article (01/2022)
3. Hu, Jiaqi: 1 article (01/2022)
4. Li, Wei: 1 article (01/2022)
5. Li, Yuanyuan: 1 article (01/2022)
6. Ling, Zihang: 1 article (01/2022)
7. Ren, Xianyue: 1 article (01/2022)
8. Tao, Xiaoan: 1 article (01/2022)
9. Wu, Tong: 1 article (01/2022)
10. Xia, Juan: 1 article (01/2022)

Related Diseases

1. Neoplasms (Cancer)
2. Glioblastoma (Glioblastoma Multiforme)
3. Hypoxia (Hypoxemia)
4. Neoplasm Metastasis (Metastasis)
01/01/2022 - "Herein, we showed that C-C motif chemokine ligand 2 (CCL2)- C-C motif chemokine receptor 4 (CCR4) signaling, but not the CCL2- C-C motif chemokine receptor 2 (CCR2) axis, induces the formation of the vav guanine nucleotide exchange factor 2 (Vav2)- Rac family small GTPase 1 (Rac1) complex to activate the phosphorylation of myosin light chain (MLC), which is involved in the regulation of cell motility and cancer metastasis. "
09/01/2021 - ": ARNO: ADP-ribosylation factor nucleotide binding site opener; CML: carboxyl methylation; Epac: exchange protein directly activated by cAMP; ER stress: endoplasmic reticulum stress; FTase: farnesyltransferase; GAP: GTPase activating protein; GDI: GDP dissociation inhibitor; GEF: guanine nucleotide exchange factor; GGTase: geranylgeranyltransferase; GGpp: geranylgeranylpyrophosphate; GGPPS: geranylgeranyl pyrophosphate synthase; GSIS: glucose-stimulated insulin secretion; HGPRTase: hypoxanthine-guanine phosphoribosyltransferase; IMPDH: inosine monophosphate dehydrogenase; α-KIC: α-ketoisocaproic acid; MPA: mycophenolic acid; MVA: mevalonic acid; NDPK: nucleoside diphosphate kinase; NMPK: nucleoside monophosphate kinase; Nox2: phagocyte-like NADPH oxidase; PAK-I: p21-activated kinase-I; β-PIX: β-Pak-interacting exchange factor; PRMT: protein arginine methyltransferase; Rac1: ras-related C3 botulinum toxin substrate 1; Tiam1: T-cell lymphoma invasion and metastasis-inducing protein 1; Trx-1: thioredoxin-1; Vav2: vav guanine nucleotide exchange factor 2."
5. T-Cell Lymphoma (Lymphoma, T Cell)

Related Drugs and Biologics

1. Chemokine Receptors
2. Chemokines
3. Protein Kinases (Protein Kinase)
4. Ligands
5. SOS1 Protein
6. Leptin
7. Arrestin
8. Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
9. Proteins (Proteins, Gene)
10. p21-Activated Kinases

Related Therapies and Procedures

1. Aftercare (After-Treatment)