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Proto-Oncogene Proteins c-bcr

A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Also Known As:
Breakpoint Cluster Region Protein; Proto-Oncogene Protein bcr; Proto-Oncogene Protein c-bcr; c-bcr Proto-Oncogene Proteins; Proto Oncogene Protein bcr; Proto Oncogene Protein c bcr; Proto Oncogene Proteins c bcr; Proto-Oncogene Proteins, bcr; Proto-Oncogene Proteins, c-bcr; bcr Proto Oncogene Proteins; c bcr Proteins; c bcr Proto Oncogene Proteins; c-bcr, Proto-Oncogene Protein; c-bcr, Proto-Oncogene Proteins; bcr Proto-Oncogene Proteins; c-bcr Proteins
Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Chang, Dong-Jo: 1 article (01/2020)
2. Cross, Michael: 1 article (01/2020)
3. Fei, Jia: 1 article (01/2020)
4. Franke, Georg-Nikolaus: 1 article (01/2020)
5. Giles, Francis J: 1 article (01/2020)
6. Gu, Chunming: 1 article (01/2020)
7. Hochhaus, Andreas: 1 article (01/2020)
8. Huang, Guiping: 1 article (01/2020)
9. Kang, Julie: 1 article (01/2020)
10. Lange, Thoralf: 1 article (01/2020)

Related Diseases

1. Leukemia
2. BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Philadelphia Chromosome
5. Neoplasms (Cancer)

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