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Cytochrome P-450 CYP3A

A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Also Known As:
CYP3A4; CYP3A5; Cytochrome P-450 CYP3A4; Cytochrome P-450 CYP3A5; Cytochrome P-450IIIA; Cytochrome P450 3A; Cytochrome P450 3A4; Cytochrome P450 3A5; Erythromycin N-Demethylase; Taurochenodeoxycholate 6-alpha-Monooxygenase; 3A5, Cytochrome P450; 6-alpha-Monooxygenase, Taurochenodeoxycholate; Cytochrome P 450 CYP3A; Cytochrome P 450 CYP3A4; Cytochrome P 450 CYP3A5; Cytochrome P 450IIIA; Erythromycin N Demethylase; N-Demethylase, Erythromycin; P-450 CYP3A, Cytochrome; P-450 CYP3A4, Cytochrome; P-450 CYP3A5, Cytochrome; P-450IIIA, Cytochrome; P450 3A, Cytochrome; P450 3A5, Cytochrome; Taurochenodeoxycholate 6 alpha Monooxygenase; CYP3A
Networked: 2017 relevant articles (76 outcomes, 401 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. van Schaik, Ron H N: 15 articles (01/2020 - 04/2004)
2. Kawakami, Junichi: 14 articles (08/2022 - 11/2011)
3. Naito, Takafumi: 14 articles (08/2022 - 11/2011)
4. Mathijssen, Ron H J: 13 articles (01/2022 - 07/2002)
5. Beijnen, Jos H: 12 articles (01/2022 - 01/2006)
6. Miura, Masatomo: 11 articles (01/2019 - 08/2008)
7. Kim, Richard B: 10 articles (01/2019 - 09/2005)
8. Thummel, Kenneth E: 10 articles (01/2018 - 09/2003)
9. Sparreboom, Alex: 9 articles (09/2015 - 07/2002)
10. Verweij, Jaap: 9 articles (09/2015 - 07/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
3. Prostatic Neoplasms (Prostate Cancer)
4. Hypertension (High Blood Pressure)
5. Body Weight (Weight, Body)

Related Drugs and Biologics

1. Cytochrome P-450 CYP3A
2. Cytochrome P-450 Enzyme System (Cytochrome P450)
3. Cytochrome P-450 CYP2C19
4. Enzymes
5. Proteins (Proteins, Gene)
6. Tacrolimus (Prograf)
7. Cytochrome P-450 CYP2D6 (CYP2D6)
8. Midazolam (Versed)
9. Cytochrome P-450 CYP2C9
10. Cytochrome P-450 CYP2C8

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Kidney Transplantation
4. Oral Administration
5. Renal Dialysis (Hemodialysis)