A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Also Known As:
CYP3A4; CYP3A5; Cytochrome P-450 CYP3A4; Cytochrome P-450 CYP3A5; Cytochrome P-450IIIA; Cytochrome P450 3A; Cytochrome P450 3A4; Cytochrome P450 3A5; Erythromycin N-Demethylase; Taurochenodeoxycholate 6-alpha-Monooxygenase; 3A5, Cytochrome P450; 6-alpha-Monooxygenase, Taurochenodeoxycholate; Cytochrome P 450 CYP3A; Cytochrome P 450 CYP3A4; Cytochrome P 450 CYP3A5; Cytochrome P 450IIIA; Erythromycin N Demethylase; N-Demethylase, Erythromycin; P-450 CYP3A, Cytochrome; P-450 CYP3A4, Cytochrome; P-450 CYP3A5, Cytochrome; P-450IIIA, Cytochrome; P450 3A, Cytochrome; P450 3A5, Cytochrome; Taurochenodeoxycholate 6 alpha Monooxygenase; CYP3A