Hepatocyte Nuclear Factor 3-beta

A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. Mutations in HNF-3beta have been associated with CONGENITAL HYPERINSULINISM.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Halmos, Balazs: 2 articles (07/2008 - 06/2004)
2.	Monti, Stefano: 2 articles (07/2008 - 06/2004)
3.	Tenen, Daniel G: 2 articles (07/2008 - 06/2004)
4.	Eisenberg, Rosana: 1 article (07/2008)
5.	Fu, Pingfu: 1 article (07/2008)
6.	Golub, Todd: 1 article (07/2008)
7.	Huang, Guosheng: 1 article (07/2008)
8.	Lawrence, Earl: 1 article (07/2008)
9.	Löwenberg, Ester: 1 article (07/2008)
10.	Markowitz, Sanford D: 1 article (07/2008)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2004 - "A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer." 07/01/2008 - "15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer."
2.	Lung Neoplasms (Lung Cancer) 06/15/2004 - "A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer." 07/01/2008 - "15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer."
3.	Adenoviridae Infections (Adenovirus Infections) 01/01/2003 - "In previous studies we used transgenic mice or recombinant adenovirus infection to increase hepatic expression of forkhead box A2 (FoxA2, previously called hepatocyte nuclear factor 3beta [HNF-3beta]), which caused diminished hepatocyte glycogen levels and reduced expression of glucose homeostasis genes. "
4.	Insulinoma 07/15/2007 - "Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells."
5.	Hepatocellular Carcinoma (Hepatoma) 02/01/2004 - "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma."

Related Drugs and Biologics

1.	CCAAT-Enhancer-Binding Proteins
2.	Glycogen
3.	Glucose (Dextrose)
4.	Upstream Stimulatory Factors
5.	Pyruvate Carboxylase
6.	Peptides (Polypeptides)
7.	Anions
8.	15-hydroxyprostaglandin dehydrogenase