Hepatocyte Nuclear Factor 1-beta

A hepatocyte nuclear factor that is closely related to HEPATOCYTE NUCLEAR FACTOR 1-ALPHA but is only weakly expressed in the LIVER. Mutations in hepatocyte nuclear factor 1-beta are associated with renal CYSTS and MATURITY-ONSET DIABETES MELLITUS type 5.

Also Known As:

Networked: 92 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Igarashi, Peter: 8 articles (01/2010 - 10/2002)
2.	Hattersley, A T: 8 articles (12/2006 - 01/2000)
3.	Hattersley, Andrew T: 7 articles (07/2009 - 01/2002)
4.	Hiesberger, Thomas: 7 articles (01/2009 - 10/2002)
5.	Ellard, Sian: 7 articles (07/2008 - 12/2002)
6.	Bellanné-Chantelot, Christine: 6 articles (10/2010 - 04/2004)
7.	Bingham, Coralie: 6 articles (07/2008 - 04/2002)
8.	Ellard, S: 6 articles (12/2006 - 01/2001)
9.	Pontoglio, Marco: 5 articles (01/2010 - 10/2002)
10.	Bingham, C: 5 articles (12/2006 - 01/2001)

Related Diseases

1.	Carcinoma (Carcinomatosis) 09/01/2008 - "The aim of this study was to systematically analyze clear cell carcinoma of the pancreas and its unique biomarker hepatocyte nuclear factor-1beta. " 04/01/2007 - "Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1beta (HNF-1beta) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary. " 01/01/2015 - "We evaluated the diagnostic value of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma. " 01/01/2015 - "Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma." 12/01/2012 - "Hepatocyte nuclear factor 1-beta (HNF1β) has recently emerged as a relatively sensitive and specific marker for ovarian clear cell carcinoma. "
2.	Type 2 Diabetes Mellitus (MODY) 10/01/1999 - "These studies strongly suggest that heterozygous mutations in the HNF-1beta gene are associated with a syndrome characterized by MODY and severe, non-diabetic renal disease. " 01/01/2008 - "Mutation in hepatocyte nuclear factor-1beta gene (TCF2) associated with MODY. " 12/01/2004 - "These results suggest that HNF-1beta gene mutations may be associated with nondiabetic renal dysfunction and diabetes in Chinese, but they are responsible for only a small percentage of early onset or multiple affected diabetes pedigrees including MODY." 12/01/2004 - "Mutation of HNF-1beta gene has been reported in early onset diabetes or MODY families and this gene has been defined as MODY5 gene. " 01/01/2002 - "Identification of a gain-of-function mutation in the HNF-1beta gene in a Japanese family with MODY."
3.	Clear Cell Adenocarcinoma 07/01/2007 - "Recent studies have noted specific expression of hepatocyte nuclear factor (HNF) 1beta in ovarian clear-cell adenocarcinoma (CCA). " 07/01/2007 - "Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium." 03/01/2007 - "Specific expression of hepatocyte nuclear factor-1beta in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis." 03/01/2007 - "Previous studies using DNA microarrays have demonstrated that hepatocyte nuclear factor-1beta (HNF-1beta) is expressed specifically in clear cell adenocarcinoma (CCC). "
4.	Neoplasms (Cancer) 01/01/2015 - "A review on hepatocyte nuclear factor-1beta and tumor." 01/01/2006 - "Our results indicate that HNF-1beta is an excellent molecular marker for ovarian clear cell tumors, including benign, borderline and malignant lesions. " 01/01/2006 - "In nine of the 12 cases, distinct nuclear immunostaining for HNF-1beta was detected in the endometriotic epithelium, as well as in the clear cell tumor. " 01/01/2006 - "All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed it. " 02/01/2005 - "HNF-1beta was not expressed or expressed very weakly in other papillary, follicular, and Hurthle cancer cell lines and primary cultures of normal thyroid cells and benign thyroid conditions. "
5.	Endometriosis (Adenomyosis) 04/01/2009 - "Recent studies based on genome-wide expression analysis technology have noted specific expression of hepatocyte nuclear factor-1beta (HNF-1beta) in endometriosis and CCC, suggesting that early differentiation into the clear cell lineage takes place in the endometriosis. " 01/01/2006 - "HNF-1beta expression was observed either in atypical endometriosis (four cases), or in endometriosis of a reactive nature (five cases). " 11/01/2009 - "HNF-1beta is also expressed in ovarian endometriosis, which is a probable origin of clear cell carcinoma. " 06/01/2006 - "Clear-cell carcinomas are characterized by mutations of TGFbetaR2 and over-expression of HNF-1beta, and probably arise from ovarian endometriosis. " 01/01/2006 - "Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary."

Related Drugs and Biologics

1.	Hepatocyte Nuclear Factor 1-beta
2.	Transcription Factors (Transcription Factor)
3.	DNA (Deoxyribonucleic Acid)
4.	Coenzyme A (CoA)
5.	papillary Thyroid cancer
6.	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)
7.	Glucokinase
8.	Insulin (Novolin)
9.	Renal cysts and diabetes syndrome
10.	insulin promoter factor 1

Related Therapies and Procedures

1.	Kidney Transplantation