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Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)

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Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.

Also Known As:

Hepatocyte Nuclear Factor 1 alpha; Albumin Proximal Factor; HNF-1alpha; Hepatocyte Nuclear Factor 1alpha; LFB1 Transcription Factor; Liver-Specific Transcription Factor LF-B1; HNF 1alpha; Liver Specific Transcription Factor LF B1

Networked: 143 relevant articles (0 outcomes, 13 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hattersley, A T: 11 articles (11/2007 - 07/2000)
2.	Zucman-Rossi, Jessica: 10 articles (02/2010 - 05/2003)
3.	Froguel, P: 8 articles (01/2007 - 01/2000)
4.	Pedersen, O: 7 articles (11/2007 - 03/2000)
5.	Ellard, S: 7 articles (11/2007 - 09/2000)
6.	Hansen, T: 7 articles (11/2007 - 03/2000)
7.	Bioulac-Sage, Paulette: 6 articles (02/2010 - 11/2003)
8.	Hattersley, Andrew T: 6 articles (02/2006 - 01/2002)
9.	Rebouissou, Sandra: 5 articles (02/2010 - 09/2004)
10.	Ellard, Sian: 4 articles (05/2013 - 12/2002)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 08/01/2008 - "The purpose of this study was to assess the 1,5-AG levels in patients with HNF-1alpha MODY and in type 2 diabetic subjects with a similar degree of metabolic control. " 05/01/2008 - "The aim of this study was to determine the prevalence of exocrine pancreas dysfunction in HNF-1alpha MODY patients. " 01/01/2007 - "In summary, our study showed no association between HNF-1alpha mutations resulting in MODY phenotype and apoM levels. " 01/01/2007 - "The aim of this study was to evaluate apoM as a biomarker for HNF-1alpha MODY. " 02/01/2003 - "The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY. "
2.	Insulin Resistance 03/01/2001 - "In this study, we tested the primary hypotheses that previously described variants in the pancreatic sulfonylurea receptor gene (SUR1 or ABCC8), glucokinase (GCK) gene, or hepatocyte nuclear factor 1alpha (TCF1 or HNF1alpha) gene contribute to the inherited deficiencies of insulin secretion and beta-cell compensation to insulin resistance, as well as the secondary hypotheses that these variants altered insulin sensitivity. "
3.	Adenoviridae Infections (Adenovirus Infections) 04/01/2002 - "In previous studies we increased liver expression of HNF-3beta by using either transgenic mice (transthyretin HNF-3beta) or recombinant adenovirus infection (AdHNF3beta), and observed diminished hepatic levels of glycogen, and glucose transporter 2 (Glut-2), as well as the HNF-6, HNF-3, HNF-1alpha, HNF-4alpha, and C/EBPalpha transcription factors. "
4.	Diabetes Mellitus 09/22/2006 - "Maturity-onset diabetes of the young (MODY3), a monogenic form of type II diabetes mellitus, results most commonly from mutations in hepatocyte nuclear factor 1alpha (HNF-1alpha). " 12/01/2002 - "Maturity onset diabetes of the young type 3 (MODY3) is a monogenic form of diabetes mellitus caused by mutations in the gene encoding for hepatocyte nuclear factor 1 alpha, HNF1 alpha. " 11/01/2002 - "Mutations in Hnf-1alpha are the most common Mendelian cause of diabetes mellitus. " 07/13/2001 - "The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus." 04/01/1997 - "The mechanisms by which mutations in the HNF-1alpha gene cause diabetes mellitus are unclear but might include abnormal pancreatic islet development during foetal life thereby limiting their later function, as well as impaired transcriptional regulation of genes that play a key role in normal pancreatic beta cell function."
5.	Neoplasms (Cancer) 05/01/2008 - "HNF-1alpha transcripts were also detected in five out of six anaplastic tumors, but not in the papillary tumors except one with weak PCR signal. " 09/30/2004 - "Mutation of TCF1 encoding hepatocyte nuclear factor 1alpha in gynecological cancer." 11/01/2003 - "Somatic inactivation of the second HNF-1alpha allele was found in liver tumors in both families. " 02/01/2010 - "Among these tumors, biallelic inactivating mutations of the hepatocyte nuclear factor 1alpha (HNF1A) transcription factor have been frequently identified and in rare cases of hepatocellular carcinomas developed in noncirrhotic liver. " 09/01/2008 - "Hepatocellular adenomas (HCAs) are a group of benign tumors forming three molecular pathological subgroups: (1) hepatocyte nuclear factor 1alpha (HNF-1alpha)-inactivated, (2) beta-catenin-activated, and (3) inflammatory. "

Related Drugs and Biologics

1.	Glucokinase
2.	Transcription Factors (Transcription Factor)
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Facilitative Glucose Transport Proteins (Glucose Transporter)
6.	CCAAT-Enhancer-Binding Protein-alpha
7.	Glycogen
8.	sulfonylurea receptor
9.	Hepatocyte Nuclear Factor 1-beta
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Contraception (Birth Control)