Fibroblast Growth Factor 7

10/01/2010 - "A significant reduction in the incidence of radiation-induced oral mucositis by Palifermin has been demonstrated. "
10/01/2014 - "Assessment of the hamster cheek pouch as a model for radiation-induced oral mucositis, and evaluation of the protective effects of keratinocyte growth factor using this model."
10/01/2014 - "Additionally, palifermin when administered on days 1, 2 and 3 after irradiation (40 Gy) reduced the severity of oral mucositis. "
01/01/2008 - "Few data are available on the efficacy of and tolerance to palifermin in the preventive treatment of oral mucositis in autograft patients treated with conditioning protocols usually used in France. "
08/01/2007 - "The efficacy of palifermin during less aggressive regimens, which cause less severe oral mucositis, is not known. "

12/01/2011 - "Furthermore, we additionally amended supportive care with palifermin as it reduced severity and prevalence of mucositis [5]."
04/01/2022 - "A meta-analysis included randomised controlled trials (RCT) for palifermin compared to placebo or no palifermin, with the key data extracted being number of events of severe mucositis (defined by WHO criteria grade 3 or 4). "
09/01/2011 - "Further studies are indicated to investigate the prophylactic potential of palifermin against intestinal mucositis."
05/20/2008 - "Future studies should evaluate higher palifermin doses with longer and more standardized assessment of acute mucositis."
08/01/2002 - "Cell kinetic studies in the murine ventral tongue epithelium: mucositis induced by radiation and its protection by pretreatment with keratinocyte growth factor (KGF)."

10/27/2001 - "Keratinocyte growth factor (KGF) ameliorates graft-versus-host disease (GVHD)-associated organ injury in murine BMT models. "
12/15/2000 - "Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury."
01/01/2012 - "Recombinant human KGF, also known as palifermin, protects epithelial cells from injury induced by chemicals, irradiation and acute murine graft-versus-host disease (GVHD). "
10/01/2011 - "However, additional data on the long-term safety of palifermin and its potential influence on graft versus host disease (GvHD) are needed. "
06/15/2009 - "Keratinocyte growth factor (KGF) protects mice from acute graft-vs-host disease and graft rejection by cytoprotective and yet incompletely understood immunological mechanisms. "

05/01/2013 - "The aim of this study was to determine whether the K-sam gene and keratinocyte growth factor (KGF) expression may be used to identify malignant tumors with a poor prognosis. "
08/01/2008 - "Current trials are investigating the use of palifermin in solid tumor settings. "
01/01/2021 - "Palifermin should not be used routinely in pediatric cancer or HSCT patients."
01/01/2020 - "The recombinant human keratinocyte growth factor (rhKGF) is clinically applied to decrease the incidence and duration of cancer therapeutic agents. "
01/01/2019 - "Palifermin reduced the incidence (OR = 4.131, P = 0.000), duration (St diff mean = 0.803, P = 0.000), and severity (St diff mean = 0.637, P = 0.000) of OM in pediatric cancer patients significantly. "

12/01/1999 - "In this study, we investigated the stimulation of epithelial wound closure by keratinocyte growth factor (KGF) in vitro and the mechanisms by which KGF overcomes the inhibition due to mechanical strain. "
06/01/1998 - "Keratinocyte growth factor on trial for wound repair."
01/01/2022 - "Keratinocyte Growth Factor-Based Strategies for Wound Re-Epithelialization."
02/05/2020 - "Finally, the role of keratinocyte growth factor (KGF) in mediating the effect of pre-activated XF-hMSCs was determined in a pulmonary epithelial wound repair model. "
01/01/2019 - "Our results demonstrate, for the first time, that topical miR-155 inhibition increases diabetic wound fibroblast growth factor 7 expression in diabetic wounds, which, in turn, increases re-epithelization and, consequently, accelerates wound closure. "