Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)

A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.

Also Known As:

Networked: 436 relevant articles (9 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Perner, Sven: 8 articles (10/2015 - 12/2010)
2.	Pitteloud, Nelly: 8 articles (03/2013 - 03/2005)
3.	Otlewski, Jacek: 7 articles (01/2022 - 01/2017)
4.	Wang, Fen: 7 articles (01/2021 - 03/2002)
5.	Wolf, Jürgen: 7 articles (09/2017 - 12/2010)
6.	Cho, Byoung Chul: 5 articles (04/2020 - 02/2013)
7.	Ogata, Tsutomu: 5 articles (01/2017 - 03/2004)
8.	Franzen, Alina: 5 articles (09/2014 - 10/2012)
9.	Plummer, Lacey: 5 articles (03/2013 - 07/2006)
10.	Quinton, Richard: 5 articles (03/2013 - 07/2006)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2019 - "In the present study, these data were further analysed and fibroblast growth factor receptor 1 (FGFR1) amplification was identified in a panel of 416 cancer-associated genes. " 11/01/2023 - "Incidental detection of myeloid/lymphoid neoplasms with fibroblast growth factor receptor 1 rearrangement on fluorodeoxyglucose positron emission tomography." 06/14/2023 - "Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. " 04/14/2023 - "FGFR1 tyrosine kinase domain duplication in infantile soft tissue spindle cell tumor." 01/01/2023 - "Complementary insights into the possible mechanism of their anti-cancer activity were provided by molecular docking calculations, exploring their ability to bind to the overexpressed fibroblast growth factor receptor 1 (FGFR1), affecting cancer cells' functionalities."
2.	Carcinoma (Carcinomatosis) 08/01/2016 - "FGFR1 protein is expressed in the majority of lung carcinomas, though it is higher in ADC and PLEOMC (the latter may reflect the importance of FGFR1 control of the EMT pathway). " 08/01/2016 - "Amplification of FGFR1 gene and expression of FGFR1 protein is found in different histological types of lung carcinoma." 07/01/2016 - "Fibroblast Growth Factor Receptor 1 Overexpression Is Associated with Poor Survival in Patients with Resected Muscle Invasive Urothelial Carcinoma." 06/15/2013 - "The fibroblast growth factor receptor 1 (FGFR1) is ectopically expressed in prostate carcinoma cells, but its functional contributions are undefined. " 01/01/2008 - "For invasive carcinoma, molecular studies will allow refinement of therapy and the possibility of novel targeted therapies, for example directed against fibroblast growth factor receptor 1."
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "Fibroblast Growth Factor Receptor 1 (FGFR1) Amplification Detected by Droplet Digital Polymerase Chain Reaction (ddPCR) Is a Prognostic Factor in Colorectal Cancers." 01/01/2015 - "Fibroblast growth factor receptor 1 (FGFR1) has been reported to be overexpressed in colorectal cancer (CRC) and suggested to be a therapeutic target. " 01/01/2013 - "Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer." 08/01/2014 - "Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression." 01/01/2013 - "Resembling a potential therapeutic drug target, fibroblast growth factor receptor 1 (FGFR1) amplification and expression was assessed in 515 human colorectal cancer (CRC) tissue samples, lymph node metastases and CRC cell lines. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2017 - "This study was conducted to explore programmed cell death-ligand-1 (PD-L1) expression and fibroblast growth factor receptor 1 (FGFR1) amplification in stage IIIB/IV lung squamous cell carcinoma (SQC). " 02/01/2023 - "High expression of fibroblast growth factor receptor 1 and phosohorylated Akt were associated with poor overall survival and disease-free survival in tongue squamous cell carcinoma, although only fibroblast growth factor receptor 1 expression was significantly associated with poor overall survival (p = 0.024; HR: 4.9, 95% CI: 1.2-19.9). " 02/01/2023 - "Fibroblast growth factor receptor 1 gene amplification was analyzed by fluorescent in situ hybridization in the tongue squamous cell carcinoma cases. " 01/01/2018 - "Association Between Fibroblast Growth Factor Receptor 1 Gene Amplification and Human Papillomavirus Prevalence in Tonsillar Squamous Cell Carcinoma With Clinicopathologic Analysis." 01/01/2018 - "Fibroblast growth factor receptor 1 (FGFR1) has been noted to be amplified in a variety of squamous cell carcinomas (SCCa) of the head, neck, and lung and increased copy number (CN) is a predictor of poor outcomes. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "The aim of this study was to investigate effects of single-nucleotide polymorphisms (SNPs) in FGFR1 on breast cancer susceptibility and FGFR1 protein expression. " 01/01/2023 - "Fibroblast growth factor receptor 1 (FGFR1) amplification is associated with breast cancer development and aberrant FGF signaling found in the biological processes related to both high mammographic density and breast cancer microenvironment. " 10/01/2022 - "FGFR1 Antibody Validation and Characterization of FGFR1 Protein Expression in ER+ Breast Cancer." 03/30/2022 - "Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts." 11/01/2020 - "Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
2.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
3.	Phosphotransferases (Kinase)
4.	Fibroblast Growth Factors (Fibroblast Growth Factor)
5.	infigratinib
6.	Aurora Kinase A
7.	Tyrosine (L-Tyrosine)
8.	ENMD 2076
9.	ErbB Receptors (EGF Receptor)
10.	Anaplastic Lymphoma Kinase

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Chemoradiotherapy
5.	Molecular Targeted Therapy