Focal Adhesion Kinase 1

A non-receptor protein tyrosine kinase with PROTEIN PHOSPHATASE 1 regulatory activity that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.

Also Known As:

Networked: 56 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hao, Kai-Min: 4 articles (01/2022 - 05/2020)
2.	Liu, Zhen: 4 articles (01/2022 - 05/2020)
3.	Qi, Wen-Xiu: 4 articles (01/2022 - 05/2020)
4.	Wang, Hao-Yu: 4 articles (01/2022 - 05/2020)
5.	De Zio, Daniela: 2 articles (01/2021 - 01/2021)
6.	Di Leo, Luca: 2 articles (01/2021 - 01/2021)
7.	Haas, Laura T: 2 articles (12/2016 - 02/2016)
8.	Strittmatter, Stephen M: 2 articles (12/2016 - 02/2016)
9.	Babu, S Haresh: 1 article (01/2022)
10.	Chen, Shuang: 1 article (01/2022)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 08/01/2018 - "Further, Cas scaffolding protein family member 4 could be used as a novel target for the treatment of Alzheimer's disease by inhibiting the protein tyrosine kinase 2 pathway." 08/01/2018 - "Molecular docking servers were used to predict the common interacting residues in both Cas scaffolding protein family member 4 and protein tyrosine kinase 2 and their involvement in Alzheimer's disease-mediated pathways. " 08/01/2018 - "Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer's disease by evaluating protein interactions through molecular docking and dynamic simulations." 08/01/2018 - "Cas scaffolding protein family member 4 and protein tyrosine kinase 2 are signaling proteins, which are involved in neuritic plaques burden, neurofibrillary tangles, and disruption of synaptic connections in Alzheimer's disease. " 01/01/2020 - "As proof of concept, we demonstrate that overexpression of protein tyrosine kinase 2 beta-an Alzheimer's disease genetic risk factor involved in synaptic plasticity and shown to decrease in Alzheimer's disease brains at gene expression and protein levels-selectively in postsynaptic neurons is protective against amyloid β1-42-induced synaptotoxicity. "
2.	Cognitive Dysfunction 10/01/2020 - "The aim of this study was to investigate the effects of histone deacetylase-6 (HDAC6) on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). " 05/15/2020 - "The aim of this study was to investigate the effects of histone deacetyltase (HDAC) 6 on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). " 05/15/2020 - "Histone deacetyltase 6 modulates amyloid β-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta." 10/25/2021 - "The aim of the present study was to explore the correlation between ptk2b/PTK2B (protein tyrosine kinase 2 beta, a ptk2b-encoded protein) and the level of low density lipoprotein receptor-related protein-1 (LRP-1), as well as to uncover the relationship between the changes in beta amyloid protein (Aβ) levels in blood and brain and the expression of ptk2b in Aβ-induced cognitive dysfunction mice. "
3.	Wounds and Injuries (Trauma) 05/15/2014 - "Focus on "Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice"." 05/15/2014 - "Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice." 06/30/2017 - "The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. "
4.	Acute Lung Injury 01/01/2023 - "This study was implemented to probe circular RNA (circRNA) protein tyrosine kinase 2 (circPTK2)-associated regulatory mechanisms in septic acute lung injury (ALI). "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 06/30/2017 - "The study aims to explore the effects of miR-135b-5p on myocardial ischemia/reperfusion (I/R) injuries by regulating Janus protein tyrosine kinase 2 (JAK2)/signal transducer and activator of transcription (STAT) signaling pathway by mediating inhalation anesthesia with sevoflurane. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Amyloid (Amyloid Fibrils)
3.	Amyloid beta-Peptides
4.	Circular RNA
5.	Histones (Histone)
6.	Proline (L-Proline)
7.	Focal Adhesion Protein-Tyrosine Kinases
8.	Non-Receptor Type 11 Protein Tyrosine Phosphatase
9.	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)
10.	Protein Tyrosine Phosphatases

Related Therapies and Procedures

1.	Inhalation Anesthesia
2.	Moxibustion