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Focal Adhesion Protein-Tyrosine Kinases

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A family of non-receptor, PROLINE-rich protein-tyrosine kinases.

Also Known As:

Focal Adhesion Kinase; Focal Adhesion Protein-Tyrosine Kinase; Focal Adhesion Protein Tyrosine Kinase Family; Focal Adhesion Protein Tyrosine Kinases; Focal Adhesion Protein-Tyrosine Kinase Family

Networked: 974 relevant articles (9 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cance, William G: 47 articles (09/2015 - 01/2003)
2.	Golubovskaya, Vita M: 40 articles (01/2015 - 08/2003)
3.	Frame, Margaret C: 13 articles (09/2015 - 12/2004)
4.	Beierle, Elizabeth A: 13 articles (06/2015 - 04/2007)
5.	Sood, Anil K: 11 articles (06/2015 - 10/2004)
6.	Guan, Jun-Lin: 11 articles (01/2015 - 02/2005)
7.	Hochwald, Steven N: 10 articles (08/2015 - 08/2009)
8.	Kurenova, Elena V: 9 articles (01/2015 - 02/2006)
9.	Basson, Marc D: 9 articles (12/2011 - 06/2004)
10.	Ho, Baotran: 8 articles (09/2015 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/08/2015 - "A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. " 10/01/2015 - "A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors." 01/01/2015 - "Mechanistic studies in tumor-derived cell lines demonstrated that focal adhesion kinase (FAK)/Src/JNK signaling regulated the enhanced proliferation downstream of Apc mutation. " 01/01/2014 - "Focal adhesion kinase (FAK) has been implicated in cellular invasion in several cell types, and FAK inhibitors are in clinical trials for cancer treatment. " 03/01/2013 - "Many studies have shown that focal adhesion kinase (FAK) is a positive regulator of tumor progression and invasion. "
2.	Neoplasm Metastasis (Metastasis) 03/01/2013 - "The aim of this study was to investigate whether focal adhesion kinase (FAK) overexpression correlates with lymph node metastases and prognosis. " 05/01/2008 - "This study was designed to investigate the inhibitory effect of AE on the metastasis potential of HO-8910PM cell line in vitro, and the role of AE in focal adhesion kinase (FAK) expression. " 04/01/2004 - "Because circumstantial evidence suggested that these properties were mediated via focal adhesion kinase (FAK), the purpose of this study was to elucidate the role of GRP-induced activation of this enzyme on properties fundamental to metastasis including cell attachment, motility, and deformability. " 08/01/2014 - "Finally, miR-129-3p decreased multiple metastasis-related genes in RCC cells, including SOX4, phosphorylation of focal adhesion kinase and MMP-2/9 expression. " 01/01/2014 - "Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. "
3.	Carcinoma (Carcinomatosis) 01/01/2014 - "High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype." 01/01/2013 - "Inhibition of focal adhesion kinase induces apoptosis in human gastric carcinoma cells (SGC-7901)." 01/01/2011 - "Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma." 01/01/2011 - "The carcinomas compared with mammary glands from untreated rats, showed upregulation of CD29 (Integrin β1) and CD49f expression, increased FAK (focal adhesion kinase) activation especially in the CD29hi population, and decreased CD61 (Integrin β3) expression. " 10/01/2010 - "Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance."
4.	Colonic Neoplasms (Colon Cancer) 08/01/2003 - "Studies of colon cancer formation in mice genetically incapable of synthesizing GRP-R suggested that this receptor's morphogenic properties were mediated via focal adhesion kinase (FAK). " 09/05/2013 - "We identified several potential PTK6 substrates in the human SW620 colon cancer cell line using mass spectrometry, including FAK (focal adhesion kinase). " 12/27/2011 - "Lunasin (10 μM) inhibited the activation of focal adhesion kinase (FAK) by 28%, 39% and 60% in RKO, HCT-116 and KM12L4 human colon cancer cells, respectively. " 06/01/2010 - "Focal adhesion kinase (FAK), which plays a pivotal role in mediating cell proliferation, survival and migration, is frequently overexpressed in human colon cancer. " 12/01/2008 - "In this work, we highlighted how focal adhesion kinase (FAK) and SFKs interacted and we analyzed how PI3K/Akt and MAPK/Erk1/2 signaling pathways were activated in early stages of colon cancer cell adhesion. "
5.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2014 - "Nuclear expression of phosphorylated focal adhesion kinase is associated with poor prognosis in human colorectal cancer." 12/01/2009 - "Focal adhesion kinase functions as an akt downstream target in migration of colorectal cancer cells." 04/01/2003 - "[Integrin/focal adhesion kinase signal transduction pathway and the invasion and metastasis of colorectal carcinoma]." 01/01/2003 - "Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses." 04/01/1997 - "Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation."

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