Aquaporin 2

Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.

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Networked: 386 relevant articles (8 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Deen, Peter M T: 20 articles (10/2018 - 02/2002)
2.	Nielsen, Søren: 14 articles (12/2013 - 03/2003)
3.	Bichet, Daniel G: 11 articles (06/2012 - 04/2002)
4.	Fenton, Robert A: 10 articles (11/2021 - 03/2008)
5.	Knepper, Mark A: 10 articles (01/2019 - 05/2003)
6.	Valenti, Giovanna: 9 articles (03/2019 - 10/2000)
7.	Sasaki, Sei: 9 articles (06/2013 - 06/2002)
8.	Wang, Weidong: 8 articles (01/2021 - 05/2003)
9.	Kwon, Tae-Hwan: 8 articles (06/2019 - 01/2004)
10.	Zhang, Yue: 7 articles (01/2020 - 03/2010)

Related Diseases

1.	Polyuria 11/01/2022 - "Similar to Cul3-/- mice, Cul3-/-/Δ9 mice displayed polyuria with loss of aquaporin 2 and collecting duct injury; proximal tubule injury also occurred. " 01/01/2012 - "Li-induced polyuria, and decreases in urine osmolality and AQP2 protein abundance in the renal medulla, were significantly less compared with WT mice despite the lack of differences in Li intake or terminal serum or inner medullary tissue Li levels. " 01/01/2010 - "Enhanced expression of renal aquaporin-2 (AQP2) has been reported when polyuria occurs in diabetic animal models. " 02/01/2007 - "The polyuria might also be attributed to reduced aquaporin 2 expression and the attendant urinary concentrating defect. " 04/27/2023 - "Animal models of a variety of acquired nephrogenic diabetes insipidus (NDI) disorders have identified a common feature: all such models are associated with the loss of aquaporin-2 (AQP2) from collecting duct principal cells, explaining the associated polyuria. "
2.	Nephrogenic Diabetes Insipidus 07/01/2010 - "In the present study, we measured whether MI could increase expression of two human aquaporin 2 (AQP2) mutants which were recently identified as causing nephrogenic diabetes insipidus (NDI). " 10/01/2000 - "Importance of aquaporin-2 expression levels in genotype -phenotype studies in nephrogenic diabetes insipidus." 01/01/2023 - "Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus." 10/01/2022 - "A Novel AQP2 Sequence Variant Causing Aquaporin-2 Retention in the Cytoplasm and Autosomal Dominant Nephrogenic Diabetes Insipidus." 01/01/2021 - "Molecular Characterization of an Aquaporin-2 Mutation Causing Nephrogenic Diabetes Insipidus."
3.	Heart Failure 08/01/2002 - "Previous studies showed that aquaporin 2 (AQP2) is elevated in the kidney of the heart failure rat suggesting that an increased amount of AQP2 contributes to water retention in heart failure. " 01/01/2019 - "Expression and subcellular distribution of aquaporin 2 (AQP2) were detected by immunoblotting and immunofluorescence in mouse inner medullary collecting duct-3 (mIMCD-3) cells and congestive heart failure model rats. " 03/01/2011 - "Effect of exercise training on renal function and renal aquaporin-2 expression in rats with chronic heart failure." 01/01/2006 - "Patients with chronic heart failure (CHF) have decreased ability to excrete water and increased urinary excretion of aquaporin-2 (U-AQP2). " 03/06/2022 - "Predictive Value of Urinary Aquaporin 2 for Acute Kidney Injury in Patients with Acute Decompensated Heart Failure."
4.	Acute Kidney Injury (Acute Renal Failure) 04/01/2000 - "The present study was aimed at investigating the changes of aquaporin 2 (AQP2) expression and its underlying mechanisms in ischemic acute renal failure (ARF). " 01/01/2019 - "Cholemic Nephropathy Causes Acute Kidney Injury and Is Accompanied by Loss of Aquaporin 2 in Collecting Ducts." 01/01/2000 - "These results suggest that reductions in expression of Na+-cotransporter genes in the proximal tubules may be important factors in the impairment in Na+-dependent reabsorption of solutes and that decrease in AQP2 protein may be involved in defect in urinary concentration ability in rabbits with ischemic acute renal failure." 03/06/2022 - "Predictive Value of Urinary Aquaporin 2 for Acute Kidney Injury in Patients with Acute Decompensated Heart Failure." 04/01/2000 - "Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats."
5.	Ischemia 01/01/2018 - "It has been reported that erythropoietin (EPO) could prevent the down-regulation of aquaporin-2 (AQP2) and urinary-concentrating defects induced by renal ischemia/reperfusion (I/R) injury. " 10/21/2008 - "To investigate the effects of erythropoietin (EPO) on the expression of aquaporin 2 (AQP(2)) after renal ischemia/reperfusion (IR). " 11/01/2005 - "Semiquantitative immunoblotting showed that NAC prevented the decreased expression of Na-K-2Cl co-transporter and aquaporin 2 after renal ischemia/reperfusion. " 08/01/1999 - "Whole kidney aquaporin-2 protein abundance was 45% of controls at 18 h, 55% of controls at 36 h, and returned to normal 72 h after ischemia. " 10/01/2014 - "Meanwhile, recombinant human erythropoietin greatly improved the ischemia-reperfusion-induced attenuation of transient receptor potential channel-6 expression (48 hr: 42% ± 2% vs 67% ± 2% and 72 hr: 55% ± 2% vs 66% ± 2%), as well as aquaporin-2 and Na,K-ATPase expression in collecting ducts. "

Related Drugs and Biologics

1.	Lithium
2.	Aquaporins (Water Channels)
3.	Vasopressin Receptors (Arginine Vasopressin Receptor)
4.	Proteins (Proteins, Gene)
5.	Adenosine Triphosphatases (ATPase)
6.	Tolvaptan
7.	Erythropoietin
8.	Ghrelin
9.	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Denervation
2.	Therapeutics
3.	Surgical Instruments (Clip)
4.	Intravenous Administration
5.	Rewarming