Aquaporin 2

Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.

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Networked: 262 relevant articles (6 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Deen, Peter M T: 18 articles (10/2014 - 02/2002)
2.	Nielsen, Søren: 14 articles (12/2013 - 03/2003)
3.	Bichet, Daniel G: 11 articles (06/2012 - 04/2002)
4.	Sasaki, Sei: 9 articles (06/2013 - 06/2002)
5.	Valenti, Giovanna: 7 articles (10/2014 - 10/2004)
6.	Knepper, Mark A: 7 articles (12/2012 - 05/2003)
7.	Frøkiaer, Jørgen: 7 articles (04/2010 - 05/2003)
8.	Fenton, Robert A: 6 articles (01/2015 - 03/2008)
9.	Svelto, Maria: 6 articles (10/2014 - 10/2004)
10.	Tamma, Grazia: 6 articles (10/2014 - 10/2004)

Related Diseases

1.	Polyuria 01/01/2012 - "Li-induced polyuria, and decreases in urine osmolality and AQP2 protein abundance in the renal medulla, were significantly less compared with WT mice despite the lack of differences in Li intake or terminal serum or inner medullary tissue Li levels. " 01/01/2010 - "Enhanced expression of renal aquaporin-2 (AQP2) has been reported when polyuria occurs in diabetic animal models. " 02/01/2007 - "The polyuria might also be attributed to reduced aquaporin 2 expression and the attendant urinary concentrating defect. " 05/31/2002 - "Severe polyuria was observed as an early event with no other obvious sequelae after Stx administration, in parallel with elevated urinary level of aquaporin 2 (AQP2) water channel protein that was determined by a sandwich EIA assay. " 06/01/1999 - "The present study was undertaken to determine whether urinary excretion of aquaporin-2 (AQP-2) water channel under ad libitum water intake is of value to differentiate polyuria caused by psychogenic polydipsia from central diabetes insipidus. "
2.	Nephrogenic Diabetes Insipidus 07/01/2010 - "In the present study, we measured whether MI could increase expression of two human aquaporin 2 (AQP2) mutants which were recently identified as causing nephrogenic diabetes insipidus (NDI). " 03/01/2004 - "The aim of this study was to describe the urological complications associated with nephrogenic diabetes insipidus (NDI) due to a mutation in aquaporin-2 (AQP2), a collecting-duct protein activated by ADH signalling. " 10/01/2000 - "Importance of aquaporin-2 expression levels in genotype -phenotype studies in nephrogenic diabetes insipidus." 01/01/2015 - "Partial nephrogenic diabetes insipidus caused by a novel AQP2 variation impairing trafficking of the aquaporin-2 water channel." 01/01/2015 - "We analyzed the impact of the aquaporin 2 mutation V71M, which causes nephrogenic diabetes insipidus in humans, on aquaporin structure and activity, using the bacterial aquaglyceroporin GlpF as a model. "
3.	Acute Kidney Injury (Acute Renal Failure) 04/01/2000 - "The present study was aimed at investigating the changes of aquaporin 2 (AQP2) expression and its underlying mechanisms in ischemic acute renal failure (ARF). " 01/01/2000 - "These results suggest that reductions in expression of Na+-cotransporter genes in the proximal tubules may be important factors in the impairment in Na+-dependent reabsorption of solutes and that decrease in AQP2 protein may be involved in defect in urinary concentration ability in rabbits with ischemic acute renal failure." 04/01/2000 - "Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats." 09/01/2003 - "Polyuria in rats with gentamicin-induced acute renal failure was associated with down-regulation of renal aquaporin 2 in the inner and outer renal medulla, and cortex. " 09/01/2003 - "The aim of this study was to investigate the effects of glycyrrhizin (200 mg/kg/day) on renal function in association with the regulation of aquaporin 2 water channel in rats with gentamicin (100 mg/kg/day)-induced acute renal failure. "
4.	Ischemia 08/01/1999 - "Whole kidney aquaporin-2 protein abundance was 45% of controls at 18 h, 55% of controls at 36 h, and returned to normal 72 h after ischemia. " 10/21/2008 - "To investigate the effects of erythropoietin (EPO) on the expression of aquaporin 2 (AQP(2)) after renal ischemia/reperfusion (IR). " 11/01/2005 - "Semiquantitative immunoblotting showed that NAC prevented the decreased expression of Na-K-2Cl co-transporter and aquaporin 2 after renal ischemia/reperfusion. " 10/01/2014 - "Meanwhile, recombinant human erythropoietin greatly improved the ischemia-reperfusion-induced attenuation of transient receptor potential channel-6 expression (48 hr: 42% ± 2% vs 67% ± 2% and 72 hr: 55% ± 2% vs 66% ± 2%), as well as aquaporin-2 and Na,K-ATPase expression in collecting ducts. " 03/08/2006 - "The present study was designed to examine whether Yukmijihwang-tang (YJT), which is a Korean decoction for the treatment of renal disease, has an effect on renal functional parameters in association with the expression of aquaporin 2 (AQP 2), Na,K-ATPase, heme oxygenase-1 (HO-1) in rats with ischemia/reperfusion-induced acute renal failure (ARF). "
5.	Hypokalemia 04/15/1996 - "Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex." 01/01/2015 - "Autophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus." 07/01/2012 - "Dietary potassium (K(+)) restriction and hypokalemia have been reported to change the abundance of most renal Na(+) and K(+) transporters and aquaporin-2 isoform, but results have not been consistent. " 10/01/2013 - "It also normalized protein levels of the large conductance calcium-activated potassium channel and the water channel aquaporin 2, and improved polyuria and hypokalemia in mutant mice. " 12/01/2012 - "Aquaporin-2 (AQP2), the vasopressin-regulated water channel of the renal collecting duct, is dysregulated in numerous disorders of water balance in people and animals, including those associated with polyuria (urinary tract obstruction, hypokalemia, inflammation, and lithium toxicity) and with dilutional hyponatremia (syndrome of inappropriate antidiuresis, congestive heart failure, cirrhosis). "

Related Drugs and Biologics

1.	Lithium
2.	Vasopressin Receptors (Arginine Vasopressin Receptor)
3.	Adenosine Triphosphatases (ATPase)
4.	Erythropoietin
5.	Calcium-Activated Potassium Channels (Calcium-Activated Potassium Channel)
6.	NF-kappa B (NF-kB)
7.	clopidogrel (Plavix)
8.	Vasopressins (Vasopressin)
9.	Arginine Vasopressin (Argipressin)
10.	Sodium

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Surgical Instruments (Clip)
3.	Surgical Portasystemic Shunt (Portosystemic Shunt)
4.	Intraperitoneal Injections