GRB10 Adaptor Protein

A binding partner for several RECEPTOR PROTEIN-TYROSINE KINASES, including INSULIN RECEPTOR and INSULIN-LIKE GROWTH FACTOR RECEPTOR. It contains a C-terminal SH2 DOMAIN and mediates various SIGNAL TRANSDUCTION pathways.

Also Known As:

Networked: 13 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wei, Qianping: 2 articles (12/2018 - 01/2014)
2.	Cao, Wuyang: 1 article (07/2022)
3.	Chen, Yuanbing: 1 article (07/2022)
4.	Gao, Qiongjue: 1 article (07/2022)
5.	Huang, Jun: 1 article (07/2022)
6.	Tang, Miao: 1 article (07/2022)
7.	Xiong, Jianbing: 1 article (07/2022)
8.	Cai, Zixin: 1 article (01/2022)
9.	Hu, Shanbiao: 1 article (01/2022)
10.	Li, Dandan: 1 article (01/2022)

Related Diseases

1.	Cognitive Dysfunction 07/01/2013 - "More importantly, we demonstrated that hippocampus-specific modulation of Grb10 protein levels led to a prominent remission of cognitive disorder, including improvements in both ultrastructural pathology and abnormal neurobehavioural changes. " 01/01/2014 - "Growth factor receptor-bound protein 10 (Grb10), a suppressor of IGF1R pathway, has been shown to play a critical role in regulating diabetes-associated cognitive impairment. " 12/01/2018 - "Grb10 (growth factor receptor-bound protein 10)-interacting GYF protein 1 (GIGYF1) can modulate insulin-like growth factor 1 receptor (IGF1R) signaling pathway, which plays an important role in regulating diabetes-associated cognitive impairment, by linking to Grb10 adapter. "
2.	Glioma (Gliomas) 07/05/2022 - "This study aimed to explore the function of growth factor receptor-bound protein 10(GRB 10) in glioma. "
3.	Silver-Russell Syndrome 11/11/2020 - "Maternal uniparental disomy of chromosome 7 is present in 5-10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with the SRS phenotype. " 01/01/2016 - "A 2-year-old boy with clinical features consistent with achondroplasia and Silver-Russell syndrome-like symptoms was found to carry a mutation in the fibroblast growth factor receptor-3 (FGFR3) gene at c.1138G > A (p.Gly380Arg) and a de novo 574 kb duplication at chromosome 7p12.1 that involved the entire growth-factor receptor bound protein 10 (GRB10) gene. "
4.	Uniparental Disomy 11/11/2020 - "Maternal uniparental disomy of chromosome 7 is present in 5-10% of patients with Silver-Russell syndrome (SRS), and duplication of 7p including GRB10 (Growth Factor Receptor-Bound Protein 10), an imprinted gene that affects pre-and postnatal growth retardation, has been associated with the SRS phenotype. "
5.	Prostatic Neoplasms (Prostate Cancer) 01/01/2018 - "Using state-of-the-art patient-derived hormone-naive prostate cancer xenograft models, we found and validated the growth factor receptor bound protein 10 gene as a driver of CRPC, indicating that it may be used as a new molecular target to enhance current CRPC therapy." 01/01/2018 - "Patient-derived Hormone-naive Prostate Cancer Xenograft Models Reveal Growth Factor Receptor Bound Protein 10 as an Androgen Receptor-repressed Gene Driving the Development of Castration-resistant Prostate Cancer."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Mitogen-Activated Protein Kinase Kinases (MEKs)
3.	Proto-Oncogene Proteins c-met
4.	Androgen Receptors (Androgen Receptor)
5.	Proteins (Proteins, Gene)
6.	Insulin (Novolin)
7.	Hormones (Hormone)
8.	Fibroblast Growth Factors (Fibroblast Growth Factor)
9.	Insulin-Like Peptides
10.	Mechanistic Target of Rapamycin Complex 1

Related Therapies and Procedures

1.	Therapeutics
2.	Castration