GRB7 Adaptor Protein

A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS, including the EPHB1 RECEPTOR. It interacts with FOCAL ADHESION KINASE and is involved in CELL MIGRATION.

Also Known As:

Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Luoh, Shiuh-Wen: 4 articles (06/2020 - 06/2011)
2.	Wilce, Jacqueline A: 4 articles (01/2020 - 01/2012)
3.	Gunzburg, Menachem J: 3 articles (01/2017 - 01/2012)
4.	Pero, Stephanie C: 3 articles (10/2015 - 04/2006)
5.	Wilce, Matthew C J: 3 articles (10/2015 - 07/2005)
6.	Villalobo, Antonio: 2 articles (05/2020 - 01/2020)
7.	Chu, Pei-Yu: 2 articles (10/2019 - 07/2009)
8.	Shen, Tang-Long: 2 articles (10/2019 - 07/2009)
9.	Chin, Koei: 2 articles (01/2019 - 01/2013)
10.	Hu, Zhi: 2 articles (01/2019 - 01/2013)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 06/01/2011 - "The purpose of this study was to examine the clinical significance of GRB7 protein expression in human breast cancer. " 06/16/2020 - "Membrane expression of GRB7 protein was observed in breast cancer cell lines with high GRB7 protein expression in vitro. " 06/01/2019 - "Overexpression of miR‑193a‑3p and growth factor receptor bound protein 7 (GRB7) combined with in vitro tumorigenic assays were conducted to determine the carcinostatic capacities of miR‑193a‑3p in HER2 positive breast cancer cells. " 10/08/2015 - "The Grb7 adaptor protein is a therapeutic target for both TNBC and HER2+ breast cancer. " 01/01/2013 - "HER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 04/05/2006 - "We found that 22 (61%) of 36 pancreatic cancer specimens had higher levels of Grb7 protein than their corresponding normal pancreatic tissue specimens. " 04/05/2006 - "Grb7 protein expression was measured by immunohistochemistry in 36 human pancreatic cancer specimens and adjacent normal pancreatic tissue. " 04/05/2006 - "In this study, we evaluated Grb7 protein as a molecular target of therapy for metastatic pancreatic cancer. " 01/01/2017 - "Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. "
3.	Ovarian Neoplasms (Ovarian Cancer) 06/16/2020 - "Objective: To study GRB7 protein expression in normal human tissues and breast and ovarian cancers, and determine its clinical significance. " 06/16/2020 - "Conclusion: GRB7 protein membrane expression may be associated with a better prognosis in breast and ovarian cancers. " 06/16/2020 - "The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers." 12/01/2021 - "Growth factor receptor bound protein 7 (GRB7) plays an important role in regulating the growth and metastasis of ovarian cancer. " 12/01/2021 - "Knockdown of growth factor receptor bound protein 7 suppresses angiogenesis by inhibiting the secretion of vascular endothelial growth factor A in ovarian cancer cells."
4.	Neoplasms (Cancer) 01/01/2022 - "GRB7 protein was expressed more highly in cancer tissues than in adjacent tissues. " 10/01/2020 - "Patients with HER2 3+ overexpression or growth factor receptor-bound protein 7 (Grb7) -positive tumors at baseline demonstrated significantly better survival (P = .007) or treatment response (P = .016), respectively. " 09/01/2020 - "Growth factor receptor bound protein-7 (GRB7) has been regarded as an important regulatory gene in the developments of various malignant tumors. " 01/01/2015 - "Overexpression of growth factor receptor-bound protein 7 (Grb7) has been found in numerous human cancers. " 05/01/2010 - "Aberrant overexpression of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v has been found in numerous human cancers. "
5.	Carcinogenesis 03/01/2016 - "Correction: Differential Functions of Growth Factor Receptor-Bound Protein 7 (GRB7) and Its Variant GRB7v in Ovarian Carcinogenesis." 05/01/2010 - "Differential functions of growth factor receptor-bound protein 7 (GRB7) and its variant GRB7v in ovarian carcinogenesis." 07/24/2009 - "Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tyrosine (L-Tyrosine)
3.	Epidermal Growth Factor (EGF)
4.	ErbB Receptors (EGF Receptor)
5.	Mediator Complex Subunit 1
6.	Cyclin A2
7.	Cyclin C
8.	Focal Adhesion Protein-Tyrosine Kinases
9.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
10.	Small Interfering RNA (siRNA)

Related Therapies and Procedures

1.	Therapeutics