Cyclin-Dependent Kinase 2

A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.

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Networked: 186 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Keyomarsi, Khandan: 4 articles (04/2012 - 03/2004)
2.	Kung, Hsiang-Fu: 2 articles (11/2015 - 06/2007)
3.	Li, Ling: 2 articles (11/2015 - 01/2015)
4.	Li, Yan: 2 articles (01/2012 - 09/2011)
5.	Mann, David J: 2 articles (10/2011 - 07/2010)
6.	Child, Emma S: 2 articles (10/2011 - 07/2010)
7.	Chwirot, Barbara W: 2 articles (07/2010 - 10/2006)
8.	Kuźbicki, Lukasz: 2 articles (07/2010 - 10/2006)
9.	Burnstein, Kerry L: 2 articles (03/2010 - 11/2003)
10.	Choi, Yung Hyun: 2 articles (09/2009 - 06/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2015 - "Cyclin dependent kinase 2 (CDK2) was regarded as a potentially therapeutic target for cancer therapy. " 06/12/2014 - "The tumor-suppressive function of CMTM7 is associated with its role in G1/S cell cycle arrest, through upregulating p27 and downregulating cyclin-dependent kinase 2 (CDK2) and 6 (CDK6). " 01/01/2014 - "Cyclin-dependent kinase 2 associate protein 1(CDK2-AP1) is a specific negative regulatory protein for CDK2, is important in the cancer cell cycle. " 07/01/2013 - "Cyclin-dependent kinase 2 (CDK2) is critically involved in cell cycling and has been proposed as a potential cancer target. " 02/01/2013 - "The tumor suppressor P12CDK2AP1 negatively regulates cyclin-dependent kinase 2 (CDK2) activities and suppresses DNA replication. "
2.	Infection 11/01/1999 - "The Cdc2 and Cdk2 protein levels were decreased with increasing time after infection. " 10/01/1998 - "A protein encoded by the latency-related gene of bovine herpesvirus 1 is expressed in trigeminal ganglionic neurons of latently infected cattle and interacts with cyclin-dependent kinase 2 during productive infection." 02/01/2004 - "Infection of AG490-treated cells with an E2F-1 adenovirus caused the induction of cyclin A, but could not overcome the drug-induced cell cycle arrest that was coincident with the repression of cyclin-dependent kinase 2 (cdk2)-associated kinase activation. " 12/01/1999 - "A subset of neurons express a protein encoded by the LR gene and the LR protein (LRP) is associated with cyclin-dependent kinase 2 (Cdk2)/cyclin complexes during productive infection (Y. " 12/15/1998 - "When MAPK was activated in wild-type mouse hepatocytes for 24 h, via infection with a construct to express an inducible oestrogen receptor-Raf-1 fusion protein (DeltaRaf:ER), the expression of p21Cip-1/WAF1 and p16INK4a CKI proteins increased, cyclin-dependent kinase 2 (cdk2) and cdk4 activities decreased, and DNA synthesis decreased. "
3.	Aneuploidy (Aneuploid) 10/03/1996 - "We observed a marked decrease in CDC2 and CDK2 kinase activity associated with a corresponding decrease in the amount of CDC2 but not CDK2 protein; a decreased growth potential of Adp21WAF1/CIP1-infected cells demonstrated by diminished [3H]thymidine incorporation, increased cell doubling time and G1-arrested cell cycle; an association between Adp21WAF1/CIP1-infected cells and inhibition of aneuploid cell accumulation; and an alteration of the malignant phenotype of cells was evidenced by the loss of anchorage-independent growth in soft agar and the failure to induce tumorigenesis in both peripheral and intracerebral xenograft models, including the prevention of tumor formation Adp21WAF1/CIP1 infection 2 days post tumor cell implantation. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "Somatic alterations of cyclin-dependent kinase 2 (CDK2)-cyclin E complex have been shown to contribute to breast cancer (BC) development and progression. " 07/01/2010 - "We also showed that the Ser124 site of Cdc25A, which is related to cyclin-dependent kinase 2, is required for I3C-induced degradation of Cdc25A in breast cancer cells, and that interruption of the ATM-Chk2 pathway suppressed I3C-induced destruction of Cdc25A. " 06/10/2006 - "In particular, LUCA-15/RBM5 increased the expression of Stat5b and BMP5 and decreased the expression of AIB1 (Amplified In Breast Cancer 1), proto-oncogene Pim-1, caspase antagonist BIRC3 (cIAP-2, MIHC), and CDK2 (cyclin-dependent kinase 2). " 09/01/2000 - "Here we show that Cdc25A is overexpressed in primary breast tumors and that such overexpression is correlated with higher levels of cyclin-dependent kinase 2 (Cdk2) enzymatic activity in vivo. " 02/13/2012 - "We demonstrated for the first time that monocillin II could arrest breast cancer cell cycle in G1 phase, which might partially be the result of its inhibition effect on the phosphorylation of the Thr160 residue of cyclin dependent kinase 2 (CDK2), a key enzyme in cell-cycle regulation. "
5.	Carcinoma (Carcinomatosis) 06/01/2006 - "Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix." 11/07/2008 - "Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells." 02/01/2006 - "The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells." 10/01/2002 - "SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells." 09/01/1998 - "Expression of cyclins A and E and cyclin-dependent kinase 2 (CDK2) was examined immunohistochemically in 190 cases of human lung carcinoma. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Thymidine
3.	Agar
4.	ABT-100
5.	kenpaullone
6.	Cyclin E
7.	Cyclins
8.	Cyclin D1
9.	Retinoblastoma Protein
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Drug Therapy (Chemotherapy)