Wiskott-Aldrich Syndrome Protein

WASP protein is mutated in WISKOTT-ALDRICH SYNDROME and is expressed primarily in hematopoietic cells. It is the founding member of the WASP protein family and interacts with CDC42 PROTEIN to help regulate ACTIN polymerization.

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Networked: 200 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Snapper, Scott B: 14 articles (11/2021 - 12/2003)
2.	Thrasher, Adrian J: 9 articles (01/2022 - 02/2005)
3.	Westerberg, Lisa S: 7 articles (01/2022 - 06/2010)
4.	Notarangelo, Luigi D: 6 articles (01/2019 - 07/2005)
5.	Ochs, Hans D: 6 articles (01/2018 - 01/2004)
6.	Billadeau, Daniel D: 5 articles (01/2022 - 11/2009)
7.	Cotta-de-Almeida, Vinicius: 5 articles (01/2022 - 02/2007)
8.	Nguyen, Deanna D: 5 articles (09/2013 - 02/2007)
9.	Machesky, Laura M: 5 articles (11/2012 - 04/2003)
10.	He, Minghui: 4 articles (01/2022 - 01/2018)

Related Diseases

1.	Autoimmune Diseases (Autoimmune Disease) 01/01/2008 - "Wiskott-Aldrich syndrome protein is a signaling molecule and instrumental for cognate and innate immunity, cell motility and protection against autoimmune disease. "
2.	Wiskott-Aldrich Syndrome 08/01/2003 - "The present study was conducted to identify the mutation types of Wiskott-Aldrich syndrome protein (WASP) gene in 3 boys suffering from Wiskott-Aldrich syndrome. " 05/01/2019 - "We did a non-randomised, open-label, phase 1/2 clinical study in paediatric patients with severe Wiskott-Aldrich syndrome, defined by either WAS gene mutation or absent Wiskott-Aldrich syndrome protein (WASP) expression or a Zhu clinical score of 3 or higher. " 01/01/2019 - "Wiskott-Aldrich syndrome (WAS) is a form of primary immunodeficiency (PIDs) resulting from mutations of the gene that encodes Wiskott-Aldrich syndrome protein (WASp). " 11/01/2018 - "Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency caused by mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of cytoskeletal dynamics in hematopoietic cells. " 01/01/2015 - "The Wiskott-Aldrich syndrome (WAS) is a severe primary immunodeficiency caused by mutations in the Wiskott-Aldrich syndrome protein (WASp), a scaffold that promotes actin polymerization and links TCR stimulation to T cell activation. "
3.	Cicatrix (Scar) 11/01/2009 - "Two new studies published in this issue of Developmental Cell by Derivery et al. and Gomez and Billadeau reveal that WASH (Wiskott-Aldrich syndrome protein and SCAR homolog) activates Arp2/3 on endosomes and plays a critical role in the fission of tubules that serve as transport intermediates during endosome sorting." 07/15/2004 - "In this study we show that Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton that belongs to the Scar/WAVE family, plays a crucial role in the control of natural killer (NK) cell cytotoxicity. " 01/01/2023 - "Real-time qPCR analysis showed that the expression of genes involved in the Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex and endosomal and lysosomal systems was altered due to this variant. " 01/01/2023 - "TRIM27 is involved in fine tuning the WASH (Wiskott-Aldrich syndrome protein and SCAR homologue) regulatory complex which regulates endosomal actin polymerization. " 01/21/2022 - "The Wiskott-Aldrich syndrome protein and SCAR homolog (WASH), an actin nucleation-promoting factor, is present in the nucleus where it regulates gene transcription and maintains nuclear organization. "
4.	Thrombocytopenia 1 06/22/2017 - "Intermittent low platelet counts hampering diagnosis of X-linked thrombocytopenia in children: report of two unrelated cases and a novel mutation in the gene coding for the Wiskott-Aldrich syndrome protein." 07/16/2013 - "The WIP C-terminal domain binds to Wiskott-Aldrich syndrome protein (WASp) and regulates its activation and degradation, and the WIP-WASp interaction has been shown to be critical for actin polymerization and implicated in the onset of WAS and X-linked thrombocytopenia. " 07/01/2010 - "Clinical aspects and genetic analysis of taiwanese patients with wiskott-Aldrich syndrome protein mutation: the first identification of x-linked thrombocytopenia in the chinese with novel mutations." 01/01/2001 - "Missense C168T in the Wiskott--Aldrich Syndrome protein gene is a common mutation in X-linked thrombocytopenia." 02/01/2000 - "X-linked thrombocytopenia identified by flow cytometric demonstration of defective Wiskott-Aldrich syndrome protein in lymphocytes."
5.	Neoplasms (Cancer) 01/01/2018 - "The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton in hematopoietic cells and mutated in two severe immunodeficiency diseases with high incidence of cancer. " 01/01/2015 - "Neural Wiskott-Aldrich syndrome protein (N-WASP) expression is associated with tumor cell invasion and migration. " 11/01/2012 - "In this article, we identify endogenous WIP at the distal tips of cancer cell invasive protrusions and we summarise recent advances in the study of the roles of WIP- and WASP-protein families during migration and invasion of normal and cancer cells related to podosome and invadopodium generation." 01/01/2023 - "The abnormal expression of the Wiskott-Aldrich syndrome protein (WASP) encoded by the Wiskott-Aldrich syndrome (WAS) gene has been implicated in tumor invasion and immune regulation. " 01/01/2019 - "Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	rho GTP-Binding Proteins (rho GTP-Binding Protein)
3.	platelet protein P47 (pleckstrin)
4.	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)
5.	Cyclic AMP Receptors (Cyclic AMP Receptor)
6.	Profilins (Profilin)
7.	p21-Activated Kinases
8.	Actin Depolymerizing Factors (Cofilins)
9.	Multiprotein Complexes
10.	Integrins

Related Therapies and Procedures

1.	Transjugular Intrahepatic Portasystemic Shunt
2.	Hematopoietic Stem Cell Transplantation