Profilins (Profilin)

01/01/2011 - "Purified natural and recombinant profilins for in vitro and in vivo allergy tests are helpful in the diagnostic work-up. "
10/04/1995 - "The results indicate that by using purified recombinant profilin, specific diagnosis of type I allergy might be improved."
01/01/2011 - "The objective of this study was to assess the frequency of sensitization to LTP and profilin using skin prick tests (SPTs) in patients referred to our allergy unit for any complaint (not only pollen and plant food allergy). "
01/01/2011 - "This study confirms the association between profilin sensitization and melon allergy."
01/01/2010 - "Preliminary results of a skin prick test-based study of the prevalence and clinical impact of hypersensitivity to pollen panallergens (polcalcin and profilin)."

04/01/2012 - "By tissue microarray analysis, profilin 1 was found to have a marked decrease of expression in the epithelial cells of the invasive (T2+) versus high risk non invasive (T1G3) tumors with occasional expression in stroma; importantly, this pattern strongly correlated with poor prognosis and increased mortality. "
01/01/2014 - "Previous studies show that profilin could be executing a dual role in cancer by either suppressing or promoting tumorigenesis in a context dependent manner. "
01/01/2012 - "In vitro studies on cancer and epithelial cell lines suggested a role for profilins in cell migration and cell-cell adhesion. "
10/01/2011 - "Several recent studies have implicated a role for the profilin (PFN) family in cancer pathogenesis and progression. "
04/01/2004 - "In the present study, we characterize the ligand binding site crucial for profilin's tumor suppressor activity. "

01/01/2013 - "Evaluation of Montanide™ ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis."
09/20/2010 - "acervulina profilin subunit vaccine in combination with Montanide adjuvants enhances protective immunity against avian coccidiosis."
11/16/2010 - "Our previous study demonstrated that chickens immunized subcutaneously with an Eimeria recombinant profilin protein vaccine emulsified in a Quil A/cholesterol/DDA/Carbopol (QCDC) adjuvant developed partial protection against experimental avian coccidiosis compared with animals immunized with profilin alone. "
03/01/2012 - "This study investigated the ability of two novel adjuvant formulations, QCDC (Quil A/cholesterol/DDA/ Carbopol) and QCDCR (QCDC/Bay R1005), in combination with a recombinant profilin vaccine, to modulate host protective immunity and to alter gene expression during experimental avian coccidiosis. "
06/01/2012 - "The effects against avian coccidiosis of two novel adjuvants, Quil A/cholesterol/dimethyl dioctadecyl ammonium bromide/Carbopol (QCDC) and QCDC/Bay R1005 (R)/cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (CpG ODN [T]) (QCDCRT) emulsified with profilin, a conserved Eimeria recombinant protein, were determined in broiler chickens. "

03/01/2013 - "These results demonstrate a crucial role for profilin-1 in hypertensive cardiac hypertrophy."
03/01/2013 - "Profilin-1 promotes cardiac hypertrophy partly through interfering with the formation of sarcolemmal caveolae and attenuating the eNOS/NO pathway. "
03/01/2013 - "The present study examined the effects of profilin-1 on hypertension-induced cardiac hypertrophy. "
03/01/2013 - "Profilin-1 promotes the development of hypertension-induced cardiac hypertrophy."
03/01/2013 - "In contrast, transgenic overexpression of profilin-1 in SHRs induced more serious cardiac hypertrophy and fibrosis with significant reduction of sarcolemmal caveolae, caveolin-3 protein, eNOS activity, and production of NO when compared with SHR controls. "

08/17/2007 - "Profilin-1: an unexpected molecule linking vascular inflammation to the actin cytoskeleton."
10/01/1996 - "Profilin content in tissues was increased but nonspecifically because inflammation resulting from adenovirus also induces higher profilin concentrations. "
01/01/2014 - "The multifaceted role of profilin-1 in adipose tissue inflammation and glucose homeostasis."
11/01/2013 - "Previously, we showed that the actin-binding protein profilin-1 (pfn) plays a role in atherogenesis because pfn heterozygote mice (PfnHet) exhibited a significant reduction in atherosclerotic lesion burden and vascular inflammation. "
01/01/2012 - "Our findings reveal that ACE2 deficiency worsens Ang II-mediated aortic inflammation and peroxynitrite production associated with the augmentation of profilin-1 expression and the activation of the Akt-ERK-eNOS signaling, suggesting potential therapeutic approaches by enhancing ACE2 action for patients with vascular diseases."