Trigeminal Autonomic Cephalalgias

Primary headache disorders that show symptoms caused by the activation of the AUTONOMIC NERVOUS SYSTEM of the TRIGEMINAL NERVE. These autonomic features include redness and tearing of the EYE, nasal congestion or discharge, facial SWEATING and other symptoms. Most subgroups show unilateral cranial PAIN.

Also Known As:

Networked: 15 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Migraine Disorders (Migraine)
2.	Headache (Headaches)
3.	Tension-Type Headache (Tension Headache)
4.	Facial Pain (Myofacial Pain)
5.	Paroxysmal Hemicrania (Chronic Paroxysmal Hemicrania)

Experts

1.	Rozen, Todd D: 2 articles (04/2015 - 06/2005)
2.	Beams, Jennifer L: 1 article (04/2015)
3.	VanderPluym, Juliana: 1 article (01/2015)
4.	Kovac, Stjepana: 1 article (03/2014)
5.	Wright, Mary-Anne: 1 article (03/2014)
6.	Matharu, Manjit: 1 article (03/2014)
7.	Eriksson, Sofia H: 1 article (03/2014)
8.	Walker, Matthew C: 1 article (03/2014)
9.	Zrinzo, Ludvic: 1 article (03/2014)
10.	Condes-Lara, Miguel: 1 article (05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Trigeminal Autonomic Cephalalgias:

1.	DroperidolFDA LinkGeneric 09/01/2012 - "The aim of this study was to describe the use and efficacy of low-dose (≤2 mg) droperidol for the treatment of primary headaches (ie, migraine, cluster, tension-type headache and trigeminal autonomic cephalalgias, and other primary headaches) in the emergency department (ED). "
2.	Clomiphene (Clomifene)FDA LinkGeneric 06/01/2005 - "Clomiphene citrate as a new treatment for SUNCT: hormonal manipulation for hypothalamic-influenced trigeminal autonomic cephalalgias." 02/01/2008 - "Hypothalamic hormonal modulation therapy with clomiphene citrate may become a new preventive choice for trigeminal autonomic cephalalgias. "
3.	Indomethacin (Indometacin)FDA LinkGeneric 01/01/2010 - "Paroxysmal hemicrania is a trigeminal autonomic cephalalgia first described in 1976, characterized by episodic attacks of excruciating unilateral periorbital and temporal stabbing, pulsatile, craw-like, or boring headaches lasting 2 - 30 minutes, accompanied by autonomic features, and alleviated by indomethacin. " 01/01/2015 - "Traditionally, indomethacin-responsive headaches include a subset of trigeminal autonomic cephalalgias (paroxysmal hemicrania and hemicrania continua), Valsalva-induced headaches (cough headache, exercise headache, and sex headache), primary stabbing headache, and hypnic headache. " 04/01/2015 - "A case of post-traumatic LASH syndrome responsive to indomethacin and melatonin (a man with a unique triad of indomethacin-responsive trigeminal autonomic cephalalgias)." 12/01/2012 - "Additionally, both sensory and autonomic manifestations were significantly inhibited by highly effective treatments for trigeminal autonomic cephalalgias, such as oxygen, indomethacin and triptans, and some part of their therapeutic action appears to be specifically on the parasympathetic outflow to the cranial vasculature. "
4.	Tryptamines (Triptans)IBA 12/01/2012 - "Additionally, both sensory and autonomic manifestations were significantly inhibited by highly effective treatments for trigeminal autonomic cephalalgias, such as oxygen, indomethacin and triptans, and some part of their therapeutic action appears to be specifically on the parasympathetic outflow to the cranial vasculature. "
5.	Testosterone (Sustanon)FDA Link 06/01/2005 - "We present a patient with treatment refractory short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) who was found to have low levels of serum testosterone supporting the hypothalamic connection to this trigeminal autonomic cephalalgia. "
6.	OxygenIBA 12/01/2012 - "Additionally, both sensory and autonomic manifestations were significantly inhibited by highly effective treatments for trigeminal autonomic cephalalgias, such as oxygen, indomethacin and triptans, and some part of their therapeutic action appears to be specifically on the parasympathetic outflow to the cranial vasculature. "
7.	Mexiletine (Mexitil)FDA LinkGeneric 04/01/2010 - "Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias." 04/01/2010 - "This article describes the role of intravenous lidocaine and mexiletine in the management of headache and trigeminal autonomic cephalalgias based on the published literature to date and provides practical guidelines for their use."
8.	MelatoninIBA 04/01/2015 - "A case of post-traumatic LASH syndrome responsive to indomethacin and melatonin (a man with a unique triad of indomethacin-responsive trigeminal autonomic cephalalgias)."
9.	Lidocaine (Xylocaine)FDA LinkGeneric 04/01/2010 - "Intravenous lidocaine and mexiletine in the management of trigeminal autonomic cephalalgias." 04/01/2010 - "This article describes the role of intravenous lidocaine and mexiletine in the management of headache and trigeminal autonomic cephalalgias based on the published literature to date and provides practical guidelines for their use."
10.	CoffeeFDA Link 09/01/2009 - "Of note, HH patients displayed typical motor activities during the headache (getting up, eating/drinking especially a cup of coffee, reading/watching television) that differentiate HH from migraine and suggest relationships between HH and trigeminal autonomic cephalalgias. "

Therapies and Procedures

1.

Deep Brain Stimulation 04/01/2010 - "Deep brain stimulation in trigeminal autonomic cephalalgias." 05/15/2013 - "While functional imaging and deep brain stimulation studies point to a pivotal role of the hypothalamus in the pathophysiology of migraine and trigeminal autonomic cephalalgias, the circuitry and the mechanisms underlying the modulation of medullary trigeminovascular (Sp5C) neurons have not been fully identified. " 05/01/2007 - "The objective of this study is to describe the therapeutic effect and the technical and surgical problems of deep brain stimulation (DBS) of the posterior hypothalamus over seven years, for treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain. " 03/01/2014 - "The PH is a candidate area involved in cluster headaches and other trigeminal autonomic cephalalgias (TACs) and is targeted for deep brain stimulation (DBS). " 05/01/2007 - "Update on neurosurgical treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain with deep brain stimulation of posterior hypothalamus: results and comments."