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Post-Dural Puncture Headache

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A secondary headache disorder attributed to low CEREBROSPINAL FLUID pressure caused by SPINAL PUNCTURE, usually after dural or lumbar puncture.

Also Known As:

Post-Lumbar Puncture Headache; Postdural Puncture Headache; Headache, Post-Dural Puncture; Headache, Postdural Puncture; Headaches, Post-Dural Puncture; Headaches, Postdural Puncture; Post Dural Puncture Headache; Post-Dural Puncture Headaches; Postdural Puncture Headaches

Networked: 437 relevant articles (36 outcomes, 40 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 6158
- Central Nervous System Diseases: 1649
  - Brain Diseases: 2114
    - Headache Disorders: 626
      - Secondary Headache Disorders: 14
        Post-Dural Puncture Headache: 437

Related Diseases

1.	Headache (Headaches)
2.	Neuralgia (Stump Neuralgia)
3.	Migraine Disorders (Migraine)
4.	Epilepsy (Aura)
5.	Back Pain (Backache)

Experts

1.	Darvish, B: 3 articles (11/2015 - 01/2011)
2.	Irestedt, L: 3 articles (11/2015 - 01/2011)
3.	Kuczkowski, K M: 3 articles (07/2006 - 09/2003)
4.	Kokki, Hannu: 2 articles (11/2015 - 07/2002)
5.	Dahlgren, G: 2 articles (11/2015 - 01/2011)
6.	Gupta, A: 2 articles (11/2015 - 01/2011)
7.	Chassard, D: 2 articles (09/2015 - 04/2013)
8.	Vassal, O: 2 articles (09/2015 - 04/2013)
9.	Ramírez, Sofía: 2 articles (07/2015 - 07/2015)
10.	Gredilla, Elena: 2 articles (07/2015 - 07/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Post-Dural Puncture Headache:

1.	Caffeine (No Doz)FDA LinkGeneric 09/01/2007 - "Is caffeine effective in preventing and treating postdural puncture headache (PDPH)? " 12/01/1998 - "Well-designed studies are necessary to demonstrate the efficacy of oral caffeine (and other drugs) in post lumbar-puncture headache." 09/01/1992 - "Treatment with caffeine and hydration for presumed postdural puncture headache resulted in relief for approximately 1 hour. " 09/01/1987 - "Should caffeine become the first-line treatment for postdural puncture headache?" 09/01/2007 - "Caffeine for the prevention and treatment of postdural puncture headache: debunking the myth."
2.	gabapentin (Neurontin)FDA LinkGeneric 07/01/2012 - "Gabapentin appears potentially beneficial in the management of patients with post-dural puncture headaches." 07/01/2012 - "Gabapentin in the treatment of post-dural puncture headache: a case series." 03/01/2007 - "Gabapentin relieves post-dural puncture headache--a report of two cases." 07/01/2014 - "Does preoperative gabapentin affects the characteristics of post-dural puncture headache in parturients undergoing cesarean section with spinal anesthesia?" 07/01/2014 - "Gabapentin is effective for treating different types of headache including post-dural puncture headache (PDPH), also used for prophylaxis against migraine. "
3.	Sumatriptan (Imigran)FDA LinkGeneric 04/01/2000 - "We do not recommend sumatriptan in patients who have exhausted conservative management of postdural puncture headache." 04/01/2000 - "Sumatriptan has been used successfully in patients with postdural puncture headache, however, its use has not been investigated in a controlled fashion. " 04/01/2000 - "Sumatriptan in patients with postdural puncture headache." 01/01/1999 - "The use of sumatriptan in the treatment of postdural puncture headache after accidental lumbar puncture complicated a blood patch procedure." 11/01/1997 - "Sumatriptan and postdural puncture headache."
4.	Dexamethasone (Maxidex)FDA LinkGeneric 09/01/2014 - "Is epidural dexamethasone effective in preventing postdural puncture headache?" 01/01/2011 - "Dexamethasone in preventing post-dural puncture headache: a randomized, double-blind, placebo-controlled trial." 02/01/2014 - "Can dexamethasone reduce postdural puncture headache?" 03/01/2015 - "Effect of dexamethasone on the incidence of post-dural puncture headache after spinal anesthesia: a randomized, double-blind, placebo-controlled trial and a meta-analysis." 03/01/2015 - "The effect of dexamethasone on post-dural puncture headache (PDPH) after spinal anesthesia has not been well elucidated. "
5.	Cosyntropin (Cortrosyn)FDA LinkGeneric 01/01/2012 - "Cosyntropin has been reported to be effective in the treatment of post-dural puncture headaches, but there is a lack of data on its effectiveness. " 08/01/2010 - "Cosyntropin for prophylaxis against postdural puncture headache after accidental dural puncture." 01/01/2000 - "Use of intravenous cosyntropin in the treatment of postdural puncture headache." 01/01/2012 - "Caffeine was 80% (95% CI 60-100%) effective and cosyntropin was 56% (95% CI 33-79%) effective in treating post-dural puncture headaches. " 01/01/2012 - "We compared the efficacy of cosyntropin with that of caffeine in the treatment of post-dural puncture headaches. "
6.	Hydrocortisone (Cortisol)FDA LinkGeneric 04/01/2012 - "The efficacy of intravenous (IV) hydrocortisone in treating the patients with postdural puncture headache was observed in this study. " 04/01/2012 - "Role of very short-term intravenous hydrocortisone in reducing postdural puncture headache." 06/01/2005 - "Three cases in which hydrocortisone was used to treat and prevent post-dural puncture headache are reported. " 06/01/2005 - "This report aimed at describing the use of hydrocortisone to treat and prevent post-dural puncture headache (PDPH). " 06/01/2005 - "[Hydrocortisone treatment and prevent post-dural puncture headache: case reports]."
7.	Hetastarch (Pentastarch)FDA Link 09/01/2015 - "Epidural blood patch is the gold standard treatment for post-dural puncture headache, although hydroxyethyl starch may be a useful alternative to blood if the latter is contraindicated. " 01/01/2015 - "Epidural injection of hydroxyethyl starch in the management of post-dural puncture headache: a case series." 11/01/2013 - "Epidural injection of hydroxyethyl starch in the management of postdural puncture headache." 04/01/2013 - "The use of an epidural hydroxyethyl starch injection may be a suitable alternative for treatment of postdural puncture headache if epidural blood patch is contraindicated." 04/01/2013 - "Epidural injection of hydroxyethyl starch in the management of postdural puncture headache."
8.	Adrenocorticotropic Hormone (ACTH)FDA Link 09/01/1997 - "Adrenocorticotropic hormone infusion as a novel treatment for postdural puncture headache." 02/01/2007 - "Adrenocorticotrophic hormone - is a single dose sufficient for post-dural puncture headache?" 09/01/1997 - "A single treatment with ACTH may offer an alternative therapy in the treatment of postdural puncture headache." 09/01/1997 - "When neither patient responded to conservative therapy following development of postdural puncture headache, an infusion of adrenocorticotropic hormone (ACTH) was given prior to consideration of epidural blood patching. " 05/01/1997 - "Postdural puncture headache and ACTH."
9.	Uridine Diphosphate (UDP)IBA 11/01/2001 - "To assess the time of occurrence, circumstances and presenting symptoms of unintentional dural puncture (UDP), the location and intensity of postdural puncture headaches (PDPH), and the efficacy of their treatment by epidural blood-patch (EBP). " 09/01/1999 - "To determine the association between bearing down, postdural puncture headache (PDPH) and epidural blood patch (EBP) following single 17 gauge unintentional dural puncture (UDP) in parturients. " 05/01/2015 - "Unintentional dural puncture (UDP) and postdural puncture headache (PDPH) occur during the course of epidural catheter placement for labor analgesia with a reported incidence of 1%-5%. "
10.	Mepivacaine (Carbocaine)FDA LinkGeneric 09/01/2003 - "Does intrathecal mepivacaine cause post lumbar puncture headache?" 09/01/2005 - "The frequent success rate and infrequent rates of complications such as TNS and postdural puncture headache suggest that spinal anesthesia with mepivacaine is likely to be a safe and effective anesthetic for ambulatory patients."

Therapies and Procedures

1.	Epidural Blood Patch 02/01/1997 - "Epidural blood patch may give immediate relief of postdural puncture headache and cranial nerve dysfunction after lumbar puncture, but the reason for the rapid and impressive effect of epidural blood patch has not been fully elucidated." 06/01/1990 - "A case is presented of a 12-year-old boy with a post-lumbar puncture headache of 6 weeks duration that was treated successfully with an epidural blood patch. " 11/01/2015 - "The elderly may also develop postdural puncture headache, and epidural blood patch is an effective and well-tolerated treatment of persistent and severe symptoms." 07/01/2012 - "Although epidural blood patch is thought to be an effective treatment for postdural puncture headache, there is insufficient evidence to support its use as a prophylactic procedure." 07/01/2011 - "Although epidural blood patch (EBP) is an effective treatment for postdural puncture headache (PDPH), the adequate blood volume has not been determined. "
2.	Bed Rest (Bedrest) 01/01/2002 - "We sought randomised, unconfounded trials, among all types of patients, that compared the effects on post-dural puncture headache of: bed rest versus early mobilisation; head-down tilt versus horizontal or prone versus supine positions during bed rest; or the administration of supplementary fluids versus control. " 04/19/1999 - "Numerous studies have not been able to identify any benefit of bedrest or excessive intake of fluids in order to prevent post-lumbar-puncture headache. " 07/01/1992 - "A randomized study of 110 patients undergoing their first diagnostic lumbar puncture was performed to compare the effect of immediate mobilization with 4 hours bed rest on the incidence of post lumbar puncture headache. " 02/01/2012 - "Does bed rest prevent post-lumbar puncture headache?" 01/01/2005 - "Although there is no evidence for the use of increased fluids or bed rest to prevent post dural puncture headache, these and other non evidence based practices continue to be used. "
3.	Spinal Anesthesia 03/01/2013 - "This study was conducted to investigate the effects of reinsertion of the stylet after a spinal anesthesia procedure on the Post Dural Puncture Headache (PDPH) METHODS: We have enrolled into this study 630 patients who were undergoing elective operations with spinal anesthesia and randomized them to Group A (stylet replacement before needle removal) and Group B (needle removal without stylet replacement). " 03/01/2013 - "This study was conducted to investigate the effects of reinsertion of the stylet after a spinal anesthesia procedure on the Post Dural Puncture Headache (PDPH). " 03/01/2011 - "Moreover, few descriptive studies or comparative trials have evaluated the efficacy and safety of continuous spinal anesthesia, probably because of concerns about potential adverse effects-principally neurologic complications and postdural puncture headache. " 10/01/2015 - "One of the most exhausting complications of spinal anesthesia, especially in parturients, is post-dural puncture headache (PDPH). " 10/01/2015 - "Postdural puncture headache (PDPH) is a benign condition and the most frequent complication of spinal anesthesia. "
4.	Nerve Block (Nerve Blocks) 01/01/2015 - " this study the efficacy of bilateral occipital nerve block was retrospectively evaluated in patients with post-dural puncture headache. " 01/01/2015 - "Ultrasound-guided bilateral greater occipital nerve block for the treatment of post-dural puncture headache." 11/01/2014 - "Greater occipital nerve block for postdural puncture headache (PDPH): a prospective audit of a modified guideline for the management of PDPH and review of the literature." 05/01/2010 - "This case report suggests that a greater occipital nerve block may be a successful alternative treatment for patients with post-dural puncture headache." 05/01/2010 - "We report a case in which a postdural puncture headache resolved within 2 minutes of a greater occipital nerve block, a minimally invasive and easy procedure with a low complication rate. "
5.	Epidural Analgesia 01/01/2006 - "By comparing the two sets of answers, we demonstrated that the leaflet has successfully improved knowledge of post dural puncture headache and other potential sequelae of obstetric epidural analgesia among general practitioners." 07/01/2008 - "We report on a female patient who developed post-dural puncture headache (PDPH) after epidural analgesia for delivery. " 07/01/2002 - "A 33-year-old parturient developed symptoms of postdural puncture headache 16 hours after initiation of epidural analgesia for labor. " 06/01/2001 - "The authors report a case of subdural haematoma (HSD), which occurred following epidural analgesia for labour, complicated by post dural puncture headache (PDPH). " 10/01/1998 - "Postdural puncture headache after combined spinal-epidural analgesia and anaesthesia."