Post-Traumatic Headache

Secondary headache attributed to TRAUMA of the HEAD and/or the NECK.

Also Known As:

Cervicogenic Headache; Cervicogenic Headaches; Headache, Cervicogenic; Headache, Post-Traumatic; Headaches, Cervicogenic; Headaches, Post-Traumatic; Post Traumatic Headache; Post-Traumatic Headaches

Networked: 333 relevant articles (42 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 14178
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Headache Disorders: 1176
      - Secondary Headache Disorders: 348
        Post-Traumatic Headache: 333

Related Diseases

1.	Headache (Headaches)
2.	Migraine Disorders (Migraine)
3.	Neck Pain (Cervicalgia)
4.	Pain (Aches)
5.	Neuralgia (Stump Neuralgia)

Experts

1.	Fernández-de-Las-Peñas, César: 9 articles (01/2022 - 09/2013)
2.	Haas, Mitchell: 7 articles (10/2018 - 01/2010)
3.	Goldsmith, Charles H: 7 articles (05/2016 - 11/2005)
4.	Ashina, Håkan: 6 articles (01/2022 - 06/2020)
5.	Vavrek, Darcy: 6 articles (10/2018 - 01/2010)
6.	Graham, Nadine: 6 articles (01/2015 - 06/2010)
7.	Schwedt, Todd J: 5 articles (10/2022 - 08/2019)
8.	Burnie, Stephen J: 5 articles (01/2015 - 06/2010)
9.	Gross, Anita: 5 articles (01/2015 - 06/2010)
10.	Butts, Raymond: 4 articles (09/2022 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Post-Traumatic Headache:

1.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2021 - "Whether botulinum toxin is a safe and effective treatment specifically for post-traumatic headache (PTH), however, is unknown. " 06/01/2012 - "The efficacy of botulinum toxin in patients with cervicogenic headache: a placebo-controlled clinical trial." 11/01/2012 - "Sufficiently large-scale clinical studies are now required to better evaluate the effects of botulinum toxin on post-traumatic headaches." 11/01/2012 - "No data on the treatment of post-traumatic headaches with botulinum toxin exist. " 11/01/2012 - "Botulinum toxin in the treatment of post-traumatic headache - case study."
2.	SteroidsIBA 09/01/2014 - "Treatment of cervicogenic headache with cervical epidural steroid injection." 03/01/2007 - "The longitudinal effectiveness of lateral atlantoaxial intra-articular steroid injection in the treatment of cervicogenic headache." 01/01/1998 - "Failure of long-term results of epidural steroid injection in cervicogenic headache." 01/01/1998 - "Epidural steroid-based technique for cervicogenic headache diagnosis." 01/01/2011 - "The aim of this pilot study was to compare the efficacy of pulsed radiofrequency to the greater occipital nerve versus a greater occipital nerve block with a mixture of local anaesthetic and steroid in the management of refractory cervicogenic headache. "
3.	salicylhydroxamic acid (SHAM)IBA 10/01/2004 - "In the present randomized, sham-controlled, patient- and evaluator-blinded study, 12 patients with a disabling, long-standing and treatment-resistant strictly unilateral cervicogenic headache were included. " 07/24/2017 - "Our objective was therefore to investigate the efficacy of chiropractic spinal manipulative therapy versus placebo (sham manipulation) and control (continued usual but non-manual management) for cervicogenic headache in a prospective 3-armed single-blinded, placebo, randomized controlled trial of 17 months' duration. " 11/23/2022 - "Nonetheless, recent guidelines on the management of cervicogenic headache underlined the lack of trials comparing manual and exercise therapy to sham or no-treatment controls. " 10/01/2004 - "Radiofrequency denervation of facet joints C2-C6 in cervicogenic headache: a randomized, double-blind, sham-controlled study." 01/01/2023 - "Remotely supervised at-home tDCS for veterans with persistent post-traumatic headache: a double-blind, sham-controlled randomized pilot clinical trial."
4.	Type A Botulinum Toxins (Botox)FDA Link 10/26/2021 - "The efficacy of botulinum toxin A treatment for tension-type or cervicogenic headache: a systematic review and meta-analysis of randomized, placebo-controlled trials." 11/01/2002 - "The aim of this review is to evaluate the studies available from reference systems and published congress contributions on the prophylactic treatment of idiopathic and cervicogenic headache with botulinum toxin A, and to classify these studies according to evidence-based medicine (EBM) criteria. " 10/01/2022 - "Investigation of onabotulinumtoxinA in a murine model of acute and persistent post-traumatic headache. " 01/01/2021 - "Botulinum Toxin Type A for the Treatment of Post-traumatic Headache: A Randomized, Placebo-Controlled, Cross-over Study." 07/01/2011 - "Cervicogenic headache and onabotulinumtoxinA: where do we stand?"
5.	Therapeutic UsesIBA 10/01/2013 - "Acupuncture combined with cervical paravertebral block is effective in relieving cervicogenic headache and improving cervical vertebral activity in cervicogenic headache patients, and can strengthen the therapeutic effect of simple paravertebral block." 05/01/2014 - "This study's objective is to characterize the therapeutic effect of peripheral nerve blocks of the scalp for children and adolescents with post-traumatic headaches. " 01/01/2023 - "To explore the therapeutic effect of C2 dorsal root ganglion pulsed radiofrequency (PRF) combined with stellate ganglion block (SGB) in patients with cervicogenic headache (CEH). " 06/25/2021 - "To compare therapeutic effects between nape acupuncture combined with manipulation and simple manipulation in treating cervicogenic headache, and to verify the synergistic effect of manipulation and nape acupuncture. " 10/01/2013 - "Comparison between the two groups showed that the VAS and ROM scores of the acupuncture group were evidently lower than those of the control group at each time point after the treatment (P < 0.05), displaying a better therapeutic effect of acupuncture plus paravertebral block for cervicogenic headache. "
6.	Oxygen (Dioxygen)IBA 01/01/2013 - "We have treated 23 patients with chronic post-traumatic headache by epidural saline and oxygen injection (ESOI) with efficacy of 96 %. " 05/01/1993 - "Oxygen inhalation, a frequently used treatment for cluster headache, was given to 14 patients with cervicogenic headache. " 05/01/1993 - "Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine."
7.	Lidocaine (Xylocaine)FDA LinkGeneric 01/01/2013 - "Current evidence does not confirm the effectiveness of IM-lidocaine injection for chronic mechanical neck pain nor anaesthetic nerve block for cervicogenic headache. " 01/01/2019 - "To compare the efficacy of 2% articaine solution and 2% lidocaine solution used to perform therapeutic nerve blocks of the large occipital nerve in patients with cervicogenic headache. "
8.	Acetaminophen (Paracetamol)FDA LinkGeneric 10/10/2023 - "Compound capsule of oxycodone and acetaminophen are effective for most of patients with post craniotomy cervicogenic headache. " 01/01/2004 - "This review evaluates use of drug therapy with paracetamol and NSAIDs, infliximab and botulinum toxin type A; manual modalities and transcutaneous electrical nerve stimulation therapy; local injection of anaesthetic or corticosteroids; and invasive surgical therapies for the treatment of cervicogenic headache. "
9.	Topiramate (Topamax)FDA LinkGeneric 01/01/2018 - "Symptoms improved with treatment specific to post-traumatic headache subtype (lumbar puncture, topiramate, or acetazolamide). " 01/01/2019 - "Migraine medications, sumatriptan and topiramate, inhibited post-traumatic headache-associated allodynia. "
10.	SolutionsIBA 01/01/2019 - "Therapeutic large occipital nerve blocks with 2% solution of articaine show the significant decrease in pain intensity and duration of pain paroxysms in a short period of time for patients with cervicogenic headache. " 01/01/2019 - "To compare the efficacy of 2% articaine solution and 2% lidocaine solution used to perform therapeutic nerve blocks of the large occipital nerve in patients with cervicogenic headache. "

Therapies and Procedures

1.	Musculoskeletal Manipulations (Manipulative Therapy) 08/01/2023 - "A large multicentre clinical trial determined that a combined program of manipulative therapy and motor control exercise is effective in the management of cervicogenic headache and outcomes are maintained in the long term. " 01/01/2004 - "It was also noted that chiropractic manipulative therapy was effective treatment for cervicogenic headaches." 07/01/2012 - "This paper systematically reviewed randomized clinical trials (RCT) assessing the efficacy of manual therapies for cervicogenic headache (CEH). " 02/01/2010 - "Lack of efficacy of manual therapy in children and adolescents with suspected cervicogenic headache: results of a prospective, randomized, placebo-controlled, and blinded trial." 01/01/2016 - "Cervical mobilization and manipulation are frequently used to treat patients diagnosed with cervicogenic headache (CEH); however, there is conflicting evidence on the efficacy of these manual therapy techniques. "
2.	Nerve Block (Nerve Blocks) 06/01/2006 - "The nerve stimulator-guided occipital nerve blockade significantly relieved cervicogenic headache and associated symptoms at two weeks following injection." 01/01/2019 - "[The efficacy of therapeutic nerve blocks in patients with cervicogenic headache]." 09/01/2015 - "Efficacy of the Greater Occipital Nerve Block for Cervicogenic Headache: Comparing Classical and Subcompartmental Techniques." 12/01/2006 - "This prospective noncomparative clinical interventional case-series study included 47 patients suffering from cervicogenic headache using a repetitive guided occipital nerve blockade. " 06/01/2006 - "This randomized, double-blind, placebo-controlled trial evaluated the effectiveness of nerve stimulator-guided occipital nerve blockade in the treatment of cervicogenic headache. "
3.	Spinal Manipulation 10/01/2018 - "Dose-response and efficacy of spinal manipulation for care of cervicogenic headache: a dual-center randomized controlled trial." 02/01/2010 - "Dose response and efficacy of spinal manipulation for chronic cervicogenic headache: a pilot randomized controlled trial." 01/01/2016 - "Dose-response of spinal manipulation for cervicogenic headache: study protocol for a randomized controlled trial." 06/01/1997 - "To study whether the isolated intervention of high-speed, low-amplitude spinal manipulation in the cervical spine has any effect on cervicogenic headache. " 01/01/2021 - "Spinal manipulation, spinal mobilization, and exercise are commonly used in individuals with cervicogenic headache (CH). "
4.	Injections 11/01/1992 - "A double blind cross-over trial has presently been conducted in 10 women with cervicogenic headache in order to investigate whether sterile water injections were effective in this disorder. " 05/01/2015 - "In this article, we will review the cervical spine anatomy, cervical facet injections, and the efficacy of cervical facet injections as a treatment for cervicogenic headache. " 04/01/2010 - "To evaluate the efficacy of upper cervical facet joint injections and spinal rami blocks in the treatment of cervicogenic headache. " 04/01/2010 - "C(1/2), C(2/3) facet joint injections and C(2), C(3) spinal rami blocks were effective and well tolerated for the treatment of cervicogenic headache in this study. " 05/01/2015 - "Cervical facet injections in the management of cervicogenic headaches."
5.	Radiofrequency Ablation 01/01/2022 - "To evaluate the feasibility and efficacy of computed tomography (CT)-guided radiofrequency ablation (RFA) of cervical intervertebral discs for the treatment of discogenic cervicogenic headache (CEH). " 01/01/2022 - "In this case series, we present 11 patients with cervicogenic headache who underwent C2 dorsal root ganglion thermal radiofrequency ablation. " 01/01/2022 - "CT-Guided C2 Dorsal Root Ganglion Radiofrequency Ablation for the Treatment of Cervicogenic Headache: Case Series and Clinical Outcomes." 01/01/2022 - "Computed tomography-guided radiofrequency ablation of cervical intervertebral discs for the treatment of refractory cervicogenic headache: A retrospective chart review." 11/01/2020 - "To evaluate the efficacy and complications of C2 dorsal root ganglion (DRG) pulsed radiofrequency ablation (RFA) for cervicogenic headache (CEH) and to identify factors related to the outcome of the procedure in this retrospective analysis. "