Glucose Transporter Type 1

A ubiquitously expressed glucose transporter that is important for constitutive, basal GLUCOSE transport. It is predominately expressed in ENDOTHELIAL CELLS and ERYTHROCYTES at the BLOOD-BRAIN BARRIER and is responsible for GLUCOSE entry into the BRAIN.

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Networked: 225 relevant articles (3 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	De Vivo, Darryl C: 5 articles (01/2021 - 04/2007)
2.	Kim, Sang Eun: 4 articles (01/2009 - 05/2007)
3.	Lee, Won Woo: 4 articles (01/2009 - 05/2007)
4.	Park, So Yeon: 4 articles (01/2009 - 05/2007)
5.	Baba, Hideo: 3 articles (07/2017 - 01/2009)
6.	Yoshida, Naoya: 3 articles (07/2017 - 01/2009)
7.	Engelstad, Kristin: 3 articles (01/2010 - 04/2007)
8.	Wang, Dong: 3 articles (01/2010 - 04/2007)
9.	Pascual, Juan M: 3 articles (11/2009 - 04/2007)
10.	Chung, Jin-Haeng: 3 articles (07/2008 - 05/2007)

Related Diseases

1.	Glut1 Deficiency Syndrome 01/01/2023 - "Ketogenic Dietary Treatments (KDTs) are to date the gold-standard treatment for glucose transporter type 1 (GLUT1) deficiency syndrome. " 01/01/2021 - "Glucose transporter type 1 (GLUT1) is the most important energy carrier of the brain across the blood-brain barrier, and a genetic defect of GLUT1 is known as GLUT1 deficiency syndrome (GLUT1DS). " 07/01/2017 - "Glucose transporter type 1 (GLUT1) deficiency syndrome (GLUT1-DS) leads to a wide range of neurological symptoms. " 01/01/2016 - "Glucose transporter type 1 deficiency syndrome is due to de novo mutations in the SLC2A1 gene encoding the glucose transporter type 1. Paroxysmal motor manifestations induced by exercise or fasting may be the main manifestations of glucose transporter type 1 deficiency syndrome. " 06/01/2005 - "We report the first two Japanese children diagnosed with glucose transporter type 1 (GLUT1) deficiency syndrome. "
2.	Hyperglycemia 01/01/2010 - "Acute hyperglycemia produces transient improvement in glucose transporter type 1 deficiency." 05/12/2017 - "We evaluated glucose transporter type 1 (GLUT1) expression by immunohistochemistry and analyzed its association with hyperglycemia and survival. " 04/01/2014 - "Hyperglycemia increased GLUT-1 protein expression. " 11/01/2001 - "We speculate that the higher cortical GLUT1 protein levels in diabetes may amplify the effects of hyperglycemia in determining higher intracellular glucose in mesangial cells, thereby contributing to diabetes-related kidney damage." 11/01/2001 - "Simultaneous assessment of total fetal glucose utilization rate (GURf) during selective hyperglycemia demonstrated a transient 40% increase at 1 and 2.5 h, corresponding temporally with a transient increase in brain GLUT-3 and liver and myocardial GLUT-1 protein amounts. "
3.	Cognitive Dysfunction 01/01/2022 - "Conclusions: THC improved cognitive impairment in mice, accompanied by reduced oxidative stress and increased GLUT1 protein levels."
4.	Neoplasms (Cancer) 05/20/2010 - "In this study, we carried out immunohistochemical detection of Glut-1 protein in many tumor and normal tissue types in a range of tissue microarrays. " 07/01/2008 - "Thus, the aim of the present study was to investigate the relationships between FDG uptake and glucose transporter type 1 (Glut-1) expression in these NE tumors. " 07/01/2007 - "The objective of this study was to investigate the expression of Glucose transporter type 1 (GLUT1) and its relation to clinicopathologic parameters in patients with salivary gland tumors. " 09/28/2023 - "More importantly, HSP90B1 promoted the localization of glucose transporter type 1, a key rate-limiting factor of glycolysis, on the plasma membrane, which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells. " 01/01/2022 - "Furthermore, GLUT1 protein expression, not ASCT2, showed a higher immunoreactivity score in PTC patients who are negative for HCV than cancer patients with positive HCV. "
5.	Carcinoma (Carcinomatosis) 11/01/2011 - "GLUT1 protein expression was found to be strongly correlated with increased malignant potential, particularly in non-invasive urothelial carcinomas. " 11/01/2011 - "Elevated GLUT1 protein expression has been observed in the majority of urothelial carcinomas, with various effects on clinicopathological parameters. " 01/01/2009 - "Glucose transporter type 1 (Glut1) has been reported to be present in several types of carcinomas. " 01/01/2005 - "However, 67% of urothelial carcinoma specimens were stained for Glut-1 protein. " 01/01/2005 - "The study showed that papilloma does not express the Glut-1 protein in contrast to urothelial carcinoma. "

Related Drugs and Biologics

1.	Dronabinol (THC)
2.	Messenger RNA (mRNA)
3.	Hexokinase
4.	Enzymes
5.	Carbonic Anhydrase IX
6.	PPAR gamma
7.	Caspase 3 (Caspase-3)
8.	Biomarkers (Surrogate Marker)
9.	Zinc
10.	Antigens

Related Therapies and Procedures

1.	Ketogenic Diet
2.	Therapeutics
3.	Radiotherapy
4.	Prostatectomy (Retropubic Prostatectomy)
5.	Diet Therapy (Therapy, Diet)