Nuclear Respiratory Factors

A family of transcription factors that control expression of a variety of nuclear GENES encoding proteins that function in the RESPIRATORY CHAIN of the MITOCHONDRIA.

Also Known As:

Nuclear Respiratory Factor; Respiratory Factor, Nuclear; Respiratory Factors, Nuclear

Networked: 14 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Nuclear Respiratory Factors: 14
      - Nuclear Respiratory Factor 1: 82
      - GA-Binding Protein Transcription Factor: 31
  - DNA-Binding Proteins: 2009
    - Nuclear Respiratory Factors: 14
      - Nuclear Respiratory Factor 1: 82
      - GA-Binding Protein Transcription Factor: 31

Experts

1.	Fu, Jianing: 1 article (01/2020)
2.	Fujisaki, Hitomi: 1 article (01/2020)
3.	Hattori, Shunji: 1 article (01/2020)
4.	Hayashi, Toshihiko: 1 article (01/2020)
5.	Ikejima, Takashi: 1 article (01/2020)
6.	Liu, Weiwei: 1 article (01/2020)
7.	Liu, Xiaojing: 1 article (01/2020)
8.	Milanesi, Lorena: 1 article (01/2020)
9.	Mizuno, Kazunori: 1 article (01/2020)
10.	Nie, Yuheng: 1 article (01/2020)

Related Diseases

1.	Cognitive Dysfunction 01/01/2017 - "We further found that the protective effects of thymol on cognitive impairments were associated with the up-regulation of nuclear respiratory factor (Nrf2)/heme oxygenase-1(HO-1) pathway. "
2.	Insulin Resistance 01/01/2005 - "Recent studies indicate that decreased expression of PPARgamma coactivator-1alpha (PGC-1alpha), a "master switch" which induces mitochondrial biogenesis by supporting the transcriptional activity of the nuclear respiratory factors, may largely account for the diminished oxidative capacity of subjects prone to insulin resistance. "
3.	Male Infertility (Male Sterility) 11/01/2017 - "In this study, we found that nuclear respiratory factor (NRF)-1, a key transcription factor for mitochondrial biogenesis, cooperated with DNA methylation to directly regulate the expression of multiple germ cell-specific genes, including Asz1 In addition, conditional ablation of NRF1 in gonocytes dramatically down-regulated these germline genes, blocked germ cell proliferation, and subsequently led to male infertility in mice. "
4.	Infections 01/01/2007 - "Molecular studies suggest that redox mechanisms activate two biogenic transcription factors, nuclear respiratory factors 1 and 2, which forestall a deterioration of oxidative phosphorylation during infection. "
5.	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/01/2020 - "Additionally, the hormone induced the expression of the nuclear respiratory factors 1 and 2 (Nrf-1 and Nrf-2), the mitochondrial transcription factors A (Tfam) and B2 (TFB2M), and the optic atrophy 1 (OPA1). " 01/01/2020 - "In addition, silibinin treatment increases mitochondrial fusion through down-regulating the expression of mitochondrial fission-associated protein dynamin-related protein 1 (DRP1) and up-regulating the expression of mitochondrial fusion-associated proteins, optic atrophy 1, mitofusin 1 and mitofusin 2. Silibinin perturbed mitochondrial biogenesis via down-regulating the levels of mitochondrial biogenesis regulators including mitochondrial transcription factor A (TFAM), peroxisome proliferator-activated receptor gamma coactivator (PGC1) and nuclear respiratory factor (NRF2). "

Related Drugs and Biologics

1.	Thymol
2.	Heme (Haem)
3.	Transcription Factors (Transcription Factor)
4.	PPAR gamma
5.	Proteins (Proteins, Gene)
6.	mitochondrial transcription factor A
7.	Messenger RNA (mRNA)
8.	Mitochondrial DNA (mtDNA)
9.	Presenilins
10.	p38 Mitogen-Activated Protein Kinases