Orofacial Granulomatosis

A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. There is no consensus on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.

Also Known As:

Networked: 48 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Contact Dermatitis (Eczema, Contact)
2.	Crohn Disease (Crohn's Disease)
3.	Hypersensitivity (Allergy)
4.	Allergic Contact Dermatitis
5.	Aphthous Stomatitis (Aphthous Ulcer)

Experts

1.	Challacombe, S J: 3 articles (12/2013 - 03/2004)
2.	Escudier, M P: 3 articles (12/2013 - 03/2004)
3.	Sanderson, J D: 3 articles (12/2013 - 03/2004)
4.	Fedele, S: 2 articles (04/2014 - 08/2004)
5.	Campbell, H E: 2 articles (12/2013 - 10/2011)
6.	Lomer, M C E: 2 articles (12/2013 - 10/2011)
7.	Mignogna, Michele D: 2 articles (01/2013 - 04/2003)
8.	Kemmler, Nicole: 2 articles (07/2012 - 01/2007)
9.	Gibson, J: 2 articles (11/2000 - 10/2000)
10.	Nagore, E: 1 article (05/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Orofacial Granulomatosis:

1.	Triamcinolone (Aristocort)FDA Link 01/01/2011 - "Orofacial granulomatosis treated with intralesional triamcinolone." 04/01/1993 - "Intralesional triamcinolone reduces lip swelling in patients with orofacial granulomatosis. " 04/01/2014 - "It has been suggested that intralesional triamcinolone injections represent a safe and effective therapeutic strategy in controlling the permanent disfiguring swelling of orofacial granulomatosis (OFG). " 08/01/2004 - "Effectiveness of small-volume, intralesional, delayed-release triamcinolone injections in orofacial granulomatosis: a pilot study."
2.	Benzoates (Benzoate)IBA 06/01/2006 - "Improvement in orofacial granulomatosis on a cinnamon- and benzoate-free diet." 10/01/2011 - "Management of orofacial granulomatosis is challenging but cinnamon- and benzoate-free diets appear to have a definite role to play." 10/01/2011 - "Review article: cinnamon- and benzoate-free diet as a primary treatment for orofacial granulomatosis." 01/01/2011 - "Food-associated allergies, especially to benzoates and cinnamon-related compounds, have been associated with orofacial granulomatosis and both standard and urticarial patch testing have been used to detect such allergies. "
3.	infliximab (Remicade)FDA Link 01/01/2007 - "Infliximab: a novel treatment option for refractory orofacial granulomatosis." 07/01/2012 - "Orofacial granulomatosis as first manifestation of Crohn's disease: successful treatment of both conditions with a combination of infliximab and dapsone."
4.	Food Additives (Food Additive)IBA 03/01/1997 - "Successive patients with a clinical diagnosis of orofacial granulomatosis were patch tested to the European Standard series and an Oral Battery containing common food additives. " 03/01/1997 - "This study was performed to document the prevalence of contact sensitivity to food additives in patients with orofacial granulomatosis and assess the role of elimination diets in management. "
5.	Thalidomide (Thalomid)FDA Link 08/01/2014 - "Thalidomide in the treatment of refractory orofacial granulomatosis." 05/01/2003 - "Thalidomide should be considered an effective therapy for the short-term treatment of severe orofacial granulomatosis in appropriately counseled patients." 04/01/2015 - "Orofacial granulomatosis and Crohn's disease may be part of the same disease; both may respond to thalidomide." 05/01/2003 - "We detail the clinical response to low-dose thalidomide of 5 patients with clinical features of orofacial granulomatosis or oral Crohn's disease recalcitrant to recognized immunosuppressant therapy. " 05/01/2003 - "Thalidomide for the treatment of recalcitrant oral Crohn's disease and orofacial granulomatosis."
6.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 04/01/2014 - "Long-term effectiveness of intralesional triamcinolone acetonide therapy in orofacial granulomatosis: an observational cohort study." 01/01/2013 - "Clinical behaviour and long-term therapeutic response in orofacial granulomatosis patients treated with intralesional triamcinolone acetonide injections alone or in combination with topical pimecrolimus 1%."
7.	T-Cell Antigen Receptors (T-Cell Receptor)IBA 04/01/2012 - "Skewed T-cell receptor variable β repertoire and massive T-cell activation in idiopathic orofacial granulomatosis." 05/01/1997 - "Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis."
8.	MercuryIBA 10/01/2006 - "However, a strong association with contact allergy to mercury in dental fillings was found in 2 patients with orofacial granulomatosis." 12/01/2003 - "Thus allergic contact dermatitis to the metals gold and mercury should be considered as a possible etiologic agent of orofacial granulomatosis." 12/01/2003 - "Contact orofacial granulomatosis caused by delayed hypersensitivity to gold and mercury." 12/01/2003 - "The authors describe orofacial granulomatosis associated with contact allergy to gold in dental crowns in one patient and a possible allergic contact reaction to mercury from dental fillings in another one. "
9.	DNA (Deoxyribonucleic Acid)IBA 10/01/2000 - "Looking for Mycobacterium paratuberculosis DNA by polymerase chain reaction (PCR) in orofacial granulomatosis (OFG) and oral Crohn's disease tissue in an Irish population." 11/01/1997 - "Search for Mycobacterium paratuberculosis DNA in orofacial granulomatosis and oral Crohn's disease tissue by polymerase chain reaction."
10.	CosmeticsIBA 08/01/2004 - "Orofacial granulomatosis (OFG) is an idiopathic disorder characterized by chronic orofacial swellings causing significant cosmetic and functional problems. " 04/01/2003 - "The recurrent chronic orofacial swelling caused by orofacial granulomatosis (OFG) can cause significant cosmetic and functional problems but can be prevented if the disease is diagnosed early and promptly treated. "

Therapies and Procedures

1.	Injections 04/01/2014 - "It has been suggested that intralesional triamcinolone injections represent a safe and effective therapeutic strategy in controlling the permanent disfiguring swelling of orofacial granulomatosis (OFG). " 08/01/2004 - "Effectiveness of small-volume, intralesional, delayed-release triamcinolone injections in orofacial granulomatosis: a pilot study." 01/01/2013 - "Clinical behaviour and long-term therapeutic response in orofacial granulomatosis patients treated with intralesional triamcinolone acetonide injections alone or in combination with topical pimecrolimus 1%."
2.	Oral Medicine 03/01/2014 - "Oral medicine case book 57: orofacial granulomatosis." 10/01/2011 - "Clinical and laboratory data for 119 cases of orofacial granulomatosis who attended oral medicine clinics in Dublin, Ireland, were examined for demographic characteristics at the time of first presentation. " 10/01/2012 - "Biologics in oral medicine: oral Crohn's disease and orofacial granulomatosis." 08/01/2012 - "Service evaluation of patients with orofacial granulomatosis and patients with oral Crohn's disease attending a paediatric oral medicine clinic." 09/01/2011 - "First, a random sample of 160 patients attending the Oral Medicine Unit of Cork University Dental School and Hospital with the following chronic oral mucosal conditions, recurrent aphthous stomatitis, oral lichen planus, the more common vesiculobullous conditions (mucous membrane pemphigoid and pemphigus vulgaris) and orofacial granulomatosis. "
3.	Nerve Block (Nerve Blocks) 10/17/1992 - "Intralesional steroid injection after nerve-block in orofacial granulomatosis." 04/01/1993 - "Intralesional steroid injection after nerve block anesthesia in the treatment of orofacial granulomatosis."
4.	Solid-State Lasers 04/01/2014 - "Unifocal orofacial granulomatosis in retromolar mucosa: surgical treatment with Er,Cr:YSGG laser."
5.	Low-Level Laser Therapy (LLLT) 06/01/2012 - "We report a case of orofacial granulomatosis successfully treated with low-level laser therapy (LLLT). " 06/01/2012 - "Orofacial granulomatosis treated with low-level laser therapy: a case report."