Proto-Oncogene Proteins c-maf

Maf proto-oncogene protein is the major cellular homolog of the V-MAF ONCOGENE PROTEIN. It was the first of the mammalian MAF TRANSCRIPTION FACTORS identified, and it is induced in activated T-LYMPHOCYTES and regulates GENETIC TRANSCRIPTION of INTERLEUKIN-4. c-maf is frequently translocated to an immunoglobulin locus in MULTIPLE MYELOMA.

Also Known As:

Proto-Oncogene Protein c-maf; c-maf Proto-Oncogene Protein; Proteins c-maf, Proto-Oncogene; Proto Oncogene Protein c maf; Proto Oncogene Proteins c maf; Proto-Oncogene Protein, c-maf; Proto-Oncogene Protein, maf; c-maf, Proto-Oncogene Protein; c-maf, Proto-Oncogene Proteins; maf Proto Oncogene Protein; c-maf Protein; maf Proto-Oncogene Protein

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abdellatif, Ahmed M: 1 article (04/2020)
2.	Fujino, Mitsunori: 1 article (04/2020)
3.	Kuno, Akihiro: 1 article (04/2020)
4.	Mizuno, Seiya: 1 article (04/2020)
5.	Ojima, Masami: 1 article (04/2020)
6.	Tagami, Asuka: 1 article (04/2020)
7.	Takahashi, Satoru: 1 article (04/2020)
8.	Cai, Zhen: 1 article (01/2017)
9.	Han, XiaoYan: 1 article (01/2017)
10.	He, DongHua: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Studies have shown that immunohistochemistry (IHC)-based detection of cancer-related genes expression could be alternative indicators for the prognosis of MM. Nuclear expression of c-maf protein in the bone marrow plasma cells of 128 multiple myeloma patients were examined by IHC, and its association with the clinicopathological features of MM patients was analyzed as well. " 09/01/2009 - "Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. "
2.	Multiple Myeloma 01/01/2017 - "Studies have shown that immunohistochemistry (IHC)-based detection of cancer-related genes expression could be alternative indicators for the prognosis of MM. Nuclear expression of c-maf protein in the bone marrow plasma cells of 128 multiple myeloma patients were examined by IHC, and its association with the clinicopathological features of MM patients was analyzed as well. " 12/01/2007 - "In multiple myeloma cell lines, glucocorticoids reduced levels of c-maf protein without influencing corresponding mRNA levels. "
3.	Hairy Cell Leukemia 09/01/2009 - "Up-regulation of c-Maf protein occurs in a small subset of myelomas, in hairy cell leukemia, and in T- and NK-cell neoplasms. "
4.	Cataract (Cataracts) 04/24/2020 - "After tamoxifen injection, adult c-MafΔTAM mice showed successful deletion of c-Maf protein and developed severe cataracts; cataracts are also seen in human patients who have mutations in the c-MAF DNA binding domain. "

Related Drugs and Biologics

1.	Tamoxifen
2.	Messenger RNA (mRNA)
3.	Glucocorticoids
4.	DNA (Deoxyribonucleic Acid)