Farnesyltranstransferase (Farnesyltransferase)

An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.

Also Known As:

Farnesyltransferase; Farnesyl Diphosphate-Geranylgeranyl Diphosphate Synthase; GGDP Synthase; GGPP Synthase; Geranylgeranyl Pyrophosphatase; Geranylgeranyl-Diphosphate Synthase; Farnesyl Diphosphate Geranylgeranyl Diphosphate Synthase; Geranylgeranyl Diphosphate Synthase; Pyrophosphatase, Geranylgeranyl; Synthase, GGDP; Synthase, GGPP; Synthase, Geranylgeranyl-Diphosphate

Networked: 508 relevant articles (27 outcomes, 102 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - Farnesyltranstransferase: 508
        Arabidopsis COX10 protein
        human GGPS1 protein
        mouse Ggps1 protein
        S pombe Cpp1 protein

Experts

1.	Wright, John J: 12 articles (05/2014 - 04/2003)
2.	Hamilton, Andrew D: 10 articles (10/2019 - 01/2003)
3.	Sebti, Said M: 10 articles (10/2019 - 03/2002)
4.	Kurzrock, Razelle: 10 articles (04/2011 - 07/2002)
5.	Sebti, S M: 10 articles (02/2007 - 01/2000)
6.	Holstein, Sarah A: 9 articles (02/2022 - 01/2017)
7.	Kaneki, Masao: 9 articles (01/2021 - 06/2007)
8.	Sebti, Saïd M: 9 articles (05/2011 - 12/2003)
9.	Lancet, Jeffrey E: 9 articles (03/2011 - 07/2002)
10.	Hamilton, A D: 9 articles (02/2007 - 01/2000)

Related Diseases

1.	Neoplasms (Cancer) 04/07/2003 - "Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. " 04/07/2003 - "Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. " 04/11/1995 - "elegans vulval development could be a simple and effective in vivo system for evaluation of farnesyltransferase inhibitors against Ras-activated tumors." 12/01/2000 - "The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung tumor model, and in tumor cell lines. " 01/01/1998 - "This is a critical finding that farnesyltransferase inhibitors may directly activate apoptotic signaling pathways in cancer cells and may help to provide a new strategy in the treatment of human cancer."
2.	Breast Neoplasms (Breast Cancer) 01/18/2022 - "In breast cancer, the promising efficacy of farnesyltransferase inhibitors (FTIs) in preclinical studies is in contrast to only limited effects in clinical Phase II-III trials. " 05/01/2011 - "Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice." 09/01/2007 - "Breast tumor models that express wild-type Ras have been shown to be sensitive to farnesyltransferase inhibitors. " 10/01/2003 - "Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma." 01/01/2004 - "New targets for therapy in breast cancer: farnesyltransferase inhibitors."
3.	Leukemia 03/01/2008 - "In this study, we show that inhibition of geranylgeranyl diphosphate synthase induces apoptosis in K562 leukemia cells. " 10/01/2011 - "Inhibition of farnesyltransferase (FT) activity has been associated with in vitro and in vivo anti-leukemia activity. " 04/01/2005 - "Farnesyltransferase inhibitors (FTIs) are currently under investigation for leukemia treatment. " 10/01/2004 - "Ras mutations have recently been implicated in the pathogenesis of acute leukemia, and inhibition of Ras signaling through the use of farnesyltransferase inhibitors (FTIs) has shown promise in early trials in acute myeloid leukemia (AML). " 01/01/2017 - "The cytotoxic effects of farnesyltransferase (FTase) inhibitors (FTIs) have been studied in cancer and leukemia cells. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 11/01/2016 - "In Vitro Apoptotic Effects of Farnesyltransferase blockade in Acute Myeloid Leukemia Cells." 03/01/2005 - "[Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia]." 01/01/2005 - "Farnesyltransferase inhibitor therapy in acute myelogenous leukemia." 10/01/2004 - "Ras mutations have recently been implicated in the pathogenesis of acute leukemia, and inhibition of Ras signaling through the use of farnesyltransferase inhibitors (FTIs) has shown promise in early trials in acute myeloid leukemia (AML). " 08/01/2003 - "Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes."
5.	Glioma (Gliomas) 11/01/1999 - "These studies demonstrate that farnesyltransferase inhibition is effective in diminishing the growth of human glioma cells in vivo. " 07/01/2002 - "We investigated for the first time the ability of farnesyltransferase inhibitors (FTI) to radiosensitize human glioma. " 08/01/2011 - "Although oncogenic Ras mutations are uncommon in gliomas, Ras has been found to be constitutively activated through the action of upstream signaling pathways, suggesting that farnesyltransferase inhibitors may show activity against these tumors. " 01/01/2015 - "As a farnesyltransferase inhibitor, Manumycin is known to induce glioma cell apoptosis in a ROS-dependent manner, and we investigated whether Manumycin could induce apoptosis in TGF-β-treated cells with elevated hCG-β exhibiting ROS-scavenging property. " 08/01/2013 - "Lonafarnib is an oral selective farnesyltransferase inhibitor, a class of drugs which have shown activity in preclinical glioma models. "

Related Drugs and Biologics

1.	tipifarnib (R115777)
2.	lonafarnib (SCH 66336)
3.	Peptidomimetics
4.	Proteins (Proteins, Gene)
5.	Paclitaxel (Taxol)
6.	FTI 277
7.	taxane
8.	Proteasome Inhibitors
9.	Tamoxifen
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Molecular Targeted Therapy
3.	Chemoprevention
4.	Therapeutics
5.	Radiotherapy