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Lymphocyte Antigen 96

A secreted protein that associates with TOLL-LIKE RECEPTOR 4 and is essential for receptor recognition of LIPOPOLYSACCHARIDES.

Also Known As:

LY96 Protein; MD-2 Protein

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Lymphocyte Antigen 96: 7
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Lymphocyte Antigen 96: 7

Experts

1.	Huang, Wei: 1 article (01/2022)
2.	Li, Jing: 1 article (01/2022)
3.	Nie, Kechao: 1 article (01/2022)
4.	Peng, Luqi: 1 article (01/2022)
5.	Zhang, Mei: 1 article (01/2022)
6.	Brennan, K M: 1 article (04/2020)
7.	Fisher-Heffernan, R E: 1 article (04/2020)
8.	Harris, L E: 1 article (04/2020)
9.	Huber, L: 1 article (04/2020)
10.	Karrow, N A: 1 article (04/2020)

Related Diseases

1.	Inflammation (Inflammations) 04/05/2023 - "ELISA, immunoprecipitation, and molecular docking indicated that L26 targeted MD-2 protein and competed with LPS to bind to MD-2, which resulted in the inhibition of inflammation. " 04/01/2020 - "Increased expression of immune-related genes including lymphocyte antigen 96, TLR-2 and NF-κB suggests that maternal AL supplementation may increase offspring sensitivity to inflammation after weaning. "
2.	Carcinogenesis 01/01/2022 - "Lymphocyte antigen 96 (LY96) is implicated in tumorigenesis by modulating host immunity. "
3.	Sepsis (Septicemia) 05/01/2023 - "Ursolic acid inhibits the release and expression of cytokines and mediators and regulates LPS-TLR4/MD-2-NF-κB signaling pathway by blocking MD-2 protein, and thus plays an anti-sepsis role."
4.	Infections 12/01/2013 - "As a secreted glycoprotein that binds to the extracellular domain of Toll-like receptor 4 (TLR4), Lymphocyte Antigen 96 (LY96), also called myeloid differentiation 2 (MD2), is required for the activation of TLR4 by lipopolysaccharide (LPS) and plays an important role in innate immunity, which is the first line of defence against microbial infections. "
5.	Hyperglycemia 01/19/2018 - "Metformin promoted HUVEC migration and inhibited apoptosis via upregulation of vascular endothelial growth factor (VEGF) receptors (VEGFR1/R2), fatty acid binding protein 4 (FABP4), ERK/mitogen-activated protein kinase signaling, chemokine ligand 8, lymphocyte antigen 96, Rho kinase 1 (ROCK1), matrix metalloproteinase 16 (MMP16) and tissue factor inhibitor-2 under hyperglycemia-chemical hypoxia. "

Related Drugs and Biologics

1.	rho-Associated Kinases
2.	Matrix Metalloproteinase 16
3.	Toll-Like Receptor 4
4.	Fatty Acid-Binding Proteins
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
7.	Mitogen-Activated Protein Kinases
8.	Chemokines
9.	Cytokines
10.	Thromboplastin (Tissue Factor)