Toll-Like Receptor 3

04/01/2013 - "Cytokine production (IL-12 and TNF-α) and surface marker expression (CD80, CD83, and CD86) in DCs matured with the Toll-like receptor 3/Melanoma Differentiation-Associated protein 5 agonist polyI:C was examined. "
04/01/2011 - "Both toll-like receptor 3 and melanoma differentiation-associated gene-5 are involved in the enhanced IFN-β production, which is associated with increased activation of NF-κB and IRF3 signaling as well as the splicing of X-box-binding protein-1 (XBP-1), an important regulator involved in ER stress response. "
08/01/2007 - "Toll-like receptor 3 expressed by melanoma cells as a target for therapy?"
02/07/2012 - "PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/Toll-IL-1 receptor domain-containing adaptor molecule 1 (TICAM-1) and melanoma differentiation-associated protein 5/IFN-β promoter stimulator 1 (IPS-1) pathways in mDCs to drive activation of natural killer cells and cytotoxic T lymphocytes. "
03/01/2011 - "As an assay, EF1α was employed to examine the changes of Toll-like receptor 3 (TLR3) and melanoma differentiation associated gene 5 (MDA5) after virus infection in CIK cells. "

06/01/2015 - "Recent studies examining the association of Toll-like receptor 3 (TLR3) gene polymorphisms with the risk of developing various types of cancer have reported conflicting results. "
02/01/2015 - "Toll-like receptor 3 has been targeted in different cancers for adjuvant therapy. "
08/01/2014 - "Association between Toll-like receptor 3 polymorphisms and cancer risk: a meta-analysis."
01/01/2014 - "The exploitation of Toll-like receptor 3 signaling in cancer therapy."
06/01/2013 - "There exists compelling evidence that Toll-like receptor 3 (TLR3) agonists can directly affect human cancer cells. "

01/01/2011 - "Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts."
01/01/2006 - "Arthritis triggered by dsRNA is not dependent on the expression of the dsRNA-signaling molecule PKR (or Toll-like receptor 3, as previously shown), but is associated with the ability to produce type I IFN and is critically dependent on type I IFN receptor signaling. "
05/01/2004 - "Although dsRNA is typically recognized by Toll-like receptor 3, Toll-like receptor 3 knockout mice developed arthritis, indicating that some other receptors are instrumental in the inducing of inflammation. "
01/01/2014 - "MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats."
01/01/2010 - "Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats."

05/01/2010 - "Investigation of the [-/A]8 and C1236T genetic variations within the human Toll-like receptor 3 gene for association with multiple sclerosis."
01/01/2014 - "Toll-like receptor 3 differently modulates inflammation in progressive or benign multiple sclerosis."
07/20/2012 - "We have demonstrated that R(+)WIN55,212-2, a synthetic cannabinoid that possesses cannabimimetic properties, acts as a novel regulator of Toll-like receptor 3 (TLR3) signaling to interferon (IFN) regulatory factor 3 (IRF3) activation and IFN-β expression, and this is critical for manifesting its protective effects in a murine multiple sclerosis model. "

01/01/2014 - "Astrocytic Toll-like receptor 3 is associated with ischemic preconditioning-induced protection against brain ischemia in rodents."
12/05/2013 - "Toll-like receptor 3 protein expression has been shown to be upregulated during cerebral ischemia/reperfusion injury in rats. "
10/01/2012 - "Toll-like receptor 3 agonist Poly I:C protects against simulated cerebral ischemia in vitro and in vivo."