Pattern Recognition Receptors

A large family of cell surface receptors that bind conserved molecular structures present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.

Also Known As:

Networked: 1302 relevant articles (5 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zipfel, Cyril: 20 articles (08/2015 - 08/2005)
2.	Netea, Mihai G: 18 articles (03/2015 - 11/2005)
3.	Akira, Shizuo: 17 articles (01/2015 - 03/2004)
4.	Brown, Gordon D: 15 articles (09/2015 - 04/2005)
5.	Bowie, Andrew G: 13 articles (12/2014 - 10/2005)
6.	Paludan, Søren R: 11 articles (08/2015 - 03/2005)
7.	Joosten, Leo A B: 11 articles (01/2015 - 03/2010)
8.	Song, Linsheng: 10 articles (10/2015 - 01/2009)
9.	Wang, Lingling: 10 articles (10/2015 - 01/2009)
10.	Ronald, Pamela C: 10 articles (03/2015 - 01/2010)

Related Diseases

1.	Porcine Reproductive and Respiratory Syndrome (PRRS) 04/01/2015 - "This study evaluated the gastrointestinal microbial diversity and the expression of pattern recognition receptors (PRRs) of the small intestine during the first week post-weaning in newly weaned piglets. " 02/01/2014 - "The regulation of phagocytosis and its outcomes by inflammatory pattern recognition receptors (PRRs) is now followed by new studies strengthening this concept and adding further complexity to the relationship between phagocytosis and innate immune signaling. " 02/01/2014 - "The purpose of this study was to extend previous in vitro data and determine the requirement for the alarmin S100A8 in the PMN response and to evaluate pattern recognition receptors (PRRs) that initiate the response. " 02/01/2014 - "In this study, we aimed to determine which pattern recognition receptors (PRRs) recognize HSV2 in primary vaginal epithelial cells. " 01/01/2014 - "The aim of this study was to assess the effect of genetic variants of genes encoding for pattern recognition receptors (PRRs) on susceptibility to RVVC. "
2.	Infection 09/01/2013 - "The murine Plasmodium berghei ANKA (PbA) infection model has helped to identify crucial players in the pathogenesis of CM. However, the role of pattern recognition receptors in innate immunity to CM induction is still poorly understood. " 09/01/2015 - "However, recent studies with newly developed experimental systems have revealed that virus infection can be recognized by pattern recognition receptors (PRR), eliciting a cytokine response that controls the replication of the virus. " 04/01/2015 - "In this study, we describe the mechanism by which group II IFNs are activated in response to NNV infection in a zebrafish cell line, by focusing on the relationship between type I IFNs and pattern recognition receptors. " 11/03/2015 - "Analysis of differentially expressed genes (DEGs) indicated that VZV infection in aged HGPS fibroblasts resembled that in senescent NHDFs, particularly in terms of genes associated with pattern recognition receptors in virus sensing network, providing novel insights into the mechanisms of senescence-associated susceptibility to VZV infection. " 09/01/2015 - "Chronicity of infection can be broken by a coordinated innate recognition of the spores by pattern recognition receptors. "
3.	Autoimmune Diseases (Autoimmune Disease) 06/15/2014 - "TLRs 7 and 8 are pattern recognition receptors controlling antiviral host defense or autoimmune diseases. " 07/01/2004 - "Indeed, several inflammatory autoimmune diseases have been linked during the past few years to defects or polymorphisms of genes encoding pattern recognition receptors. " 02/01/2008 - "Indeed, deficiencies and/or knock-out mouse studies have highlighted critical roles for soluble pattern recognition receptors in the clearance of apoptotic bodies and protection from autoimmune diseases along with mediating protection from specific infections. " 06/01/2015 - "The activation of some pattern recognition receptors (PRRs) in response to ERVs has been described in mice and in the context of human autoimmune diseases. " 07/01/2004 - "This brought toll-like receptors and other pattern recognition receptors into focus as potential players in the induction of autoimmune diseases. "
4.	Inflammation 12/10/2015 - "This type of inflammation is mediated by damage-associated molecular patterns (DAMPs) that are released upon cellular injury to activate pattern recognition receptors on innate immune cells and amplify organ damage. " 01/01/2015 - "Expression of innate immune receptors varies among organs and species and within different strains among the same species; thus, periodic classification of different pattern recognition receptors in the available strains is necessary to initiate different therapeutic approaches to combat inflammation. " 12/01/2014 - "Pattern recognition receptors are essential mediators of host defense and inflammation in the gastrointestinal system. " 09/01/2014 - "Pattern recognition receptors: curbing gut inflammation." 03/01/2014 - "As DAMPs can attract and activate immune cells upon binding to pattern recognition receptors, we propose that their release may contribute to neutrophilic airway inflammation. "
5.	Neoplasms (Cancer) 08/01/2009 - "The study by Besch et al. in this issue of the JCI now demonstrates that agents designed to stimulate the innate immune system by activating intracellular pattern recognition receptors can kill cancer cells in a direct, cell-autonomous fashion (see the related article beginning on page 2399). " 12/08/2015 - "We propose that the innate response in tumors may partially originate from direct interaction of immunogenic ncRNAs expressed in cancer cells with innate pattern recognition receptors, and thereby assign a previously unidentified danger-associated function to a set of dark matter repetitive elements. " 01/01/2015 - "Editorial: Pattern Recognition Receptors and Cancer." 01/01/2012 - "Inherited variation in pattern recognition receptors and cancer: dangerous liaisons?" 02/01/2010 - "The critical factor for tumor immunotolerance is the establishment of immunosuppressive microenvironment by interaction between pattern recognition receptors with pathogen-associated molecular patterns and damage-associated molecular patterns released from tumor tissue. "

Related Drugs and Biologics

1.	Toll-Like Receptors (Toll-Like Receptor)
2.	Ligands
3.	poly(2- acrylamido- 2- methyl- 1- propanesulfonic acid)
4.	DNA receptor (receptor, DNA)
5.	Amyloid (Amyloid Fibrils)
6.	Synucleins
7.	Prions
8.	Cytokines
9.	Messenger RNA (mRNA)
10.	Inflammasomes

Related Therapies and Procedures

1.	Immunotherapy
2.	Stem Cell Transplantation
3.	Transplants (Transplant)
4.	Ligation
5.	Stents