Plectin

A cytoskeletal linker protein with a molecular weight of greater than 500 kDa. It binds INTERMEDIATE FILAMENTS; MICROTUBULES; and MICROFILAMENTS and plays a central role in the organization and stability of the CYTOSKELETON. Plectin is phosphorylated by CALMODULIN KINASE; PROTEIN KINASE A; and PROTEIN KINASE C.

Also Known As:

Networked: 175 relevant articles (0 outcomes, 10 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wiche, Gerhard: 26 articles (12/2015 - 01/2002)
2.	Lai, Yih-Shyong: 8 articles (01/2015 - 01/2004)
3.	Liu, Yi-Hsiang: 8 articles (01/2015 - 01/2004)
4.	Cheng, Chiung-Chi: 8 articles (01/2015 - 01/2004)
5.	Fischer, Irmgard: 7 articles (08/2015 - 02/2003)
6.	Hsu, Yung-Hsiang: 7 articles (01/2015 - 01/2007)
7.	Ho, Chin-Chin: 7 articles (04/2011 - 01/2004)
8.	Pei, Ren-Jeng: 7 articles (04/2011 - 01/2004)
9.	Chao, Wei-Ting: 6 articles (01/2015 - 04/2008)
10.	Sonnenberg, Arnoud: 5 articles (07/2015 - 01/2003)

Related Diseases

1.	Muscular Dystrophies (Muscular Dystrophy) 10/01/2010 - "This study demonstrates that plectin deficiency can indeed lead to both muscular dystrophy and pyloric atresia in an individual EBS patient." 07/01/2015 - "Rodless plectin mice develop normally without signs of skin blistering or muscular dystrophy. " 01/01/2015 - "Mutations in plectin, a widely expressed giant cytolinker protein can lead to different diseases mostly with signs of muscular dystrophy (MD) and skin blistering. " 01/01/2013 - "Mutations in the human plectin gene result in multiple diseases manifesting with muscular dystrophy, skin blistering, and signs of neuropathy. " 04/01/2010 - "Autosomal recessive forms of EBS associated with extracutaneous manifestations, such as muscular dystrophy (MIM 226670) or pyloric atresia (MIM 612138), have been linked to genetic mutations in the gene for plectin (PLEC). "
2.	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 12/15/2015 - "We further demonstrate that keratinocytes have abnormal nuclear morphologies in the epidermis of plectin-deficient, epidermolysis bullosa simplex patients. " 06/01/2015 - "Mutation in exon 1a of PLEC, leading to disruption of plectin isoform 1a, causes autosomal-recessive skin-only epidermolysis bullosa simplex." 03/01/2015 - "Plectin deficiency causes autosomal recessive epidermolysis bullosa simplex (EBS) with involvement of the skin and other organs, such as muscle and gastrointestinal tract, depending on the expression pattern of the defective protein. " 01/01/2014 - "Plectin mutations underlie epidermolysis bullosa simplex in 8% of patients." 03/01/2010 - "Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex."
3.	Bullous Pemphigoid (Pemphigoid) 04/01/2000 - "A vesicular bullous pemphigoid with an autoantibody against plectin." 12/01/2012 - "Peristomal and generalized bullous pemphigoid in patients with underlying inflammatory bowel disease: is plectin the missing link?" 10/01/2009 - "Plectin is a minor pemphigoid antigen with an immunodominant epitope located on the central rod domain." 01/15/2003 - "The results show that: (1) bullous pemphigoid antigen (BP) 180 binds not only to BP230, but also to plectin. " 01/01/2001 - "Plectin, an unusual target antigen in bullous pemphigoid."
4.	Neoplasms (Cancer) 01/01/2015 - "In the present study the potential prognostic value of plectin was evaluated by a tissue microarray (TMA) based immunohistochemical analysis of primary tumor tissue obtained from a North Norwegian cohort of 115 patients diagnosed with OSCC. " 04/01/2015 - "The 500 kDa protein plectin is essential for the cytoskeletal organization of most mammalian cells and it is up-regulated in some types of cancer. " 01/01/2015 - "Furthermore, the expression of plectin was found to correlate (p = 0.01) with the expression of uPAR, which we have previously found to be a potential prognostic marker for T1N0 tumors. " 01/01/2015 - "The statistical analysis revealed that low expression of plectin in the tumor cells predicted a favorable outcome for patients with non-metastatic disease (p = 0.008). " 01/01/2015 - "Therefore, it is hypothesized that the plectin deficiency-mediated collapse of cytoskeleton may modulate cellular motility that is associated with consequent metastatic behaviors of cancer cells. "
5.	Hepatocellular Carcinoma (Hepatoma) 04/01/2008 - "Conclusively, this study offers a hypothesis that plectin deficient might play an important role in the tumorigenesis of hepatocellular carcinoma." 04/15/2011 - "As cells of hepatocellular carcinoma are morphologically different from healthy human hepatocytes, we hypothesized that plectin deficiency and cytoskeletal disorganization underlies this pleomorphic transformation. " 03/01/2011 - "As cells of hepatocellular carcinoma are morphologically different from normal human hepatocytes, we hypothesized that altered plectin expression and cytoskeletal organization underlies this pleomorphic transformation. " 09/01/2008 - "By affecting the organization of IFs, plectin might play an important role in the pleomorphism of hepatoma cells and even the tumorigenesis of hepatoma." 04/01/2008 - "The results revealed that plectin was deficient and cytokeratin18 was modulated in hepatocellular carcinoma. "

Related Drugs and Biologics

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3.	envoplakin
4.	Vimentin
5.	Carrier Proteins (Binding Protein)
6.	Phosphotransferases (Kinase)
7.	Proteins (Proteins, Gene)
8.	Desmin
9.	Antibodies
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