gamma Catenin (Plakoglobin)

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

Also Known As:

Networked: 292 relevant articles (2 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saffitz, Jeffrey E: 8 articles (09/2013 - 05/2004)
2.	Asimaki, Angeliki: 7 articles (09/2013 - 09/2006)
3.	McKenna, William J: 7 articles (10/2011 - 05/2004)
4.	Thiene, Gaetano: 6 articles (09/2013 - 11/2002)
5.	Basso, Cristina: 6 articles (09/2013 - 11/2002)
6.	Protonotarios, Nikos: 5 articles (10/2011 - 05/2004)
7.	Tsatsopoulou, Adalena: 5 articles (10/2011 - 05/2004)
8.	Syrris, Petros: 4 articles (04/2011 - 09/2006)
9.	Wichter, Thomas: 4 articles (02/2011 - 12/2002)
10.	Hardisson, David: 4 articles (08/2006 - 11/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "In this study, we demonstrate a functional role for plakoglobin in the shedding of tumor cells from the primary site into the circulation. " 08/28/2014 - "Thus, CTC clusters are derived from multicellular groupings of primary tumor cells held together through plakoglobin-dependent intercellular adhesion, and though rare, they greatly contribute to the metastatic spread of cancer." 08/01/2013 - "Although mutations in the plakoglobin gene (Jup) and/or changes in its protein levels have been observed in various disease states, including cancer progression or cardiovascular defects, the information about endogenous or exogenous stimuli orchestrating Jup expression is limited. " 08/01/2013 - "Plakoglobin is an important component of intercellular junctions, including both desmosomes and adherens junctions, which is known as a tumor suppressor. " 01/01/2013 - "In conclusion, we found that DSG3 functions as an oncogene and facilitates cancer growth and invasion in HNC cells through the DSG3-plakoglobin-TCF/LEF pathway."
2.	Adenocarcinoma 11/01/2002 - "In conclusion, ATRA and CAT show anti-metastatic potential in the invasive rat prostate adenocarcinoma model and gamma-catenin appears to play a mechanistic role." 11/01/1998 - "We examined the expression of E-CD and alpha-, beta- and gamma-catenin immunohistochemically in 18 BACs (9 mucinous, 7 nonmucinous, and 2 sclerosing) in comparison with CPAs, all of which were well-differentiated adenocarcinomas. " 04/01/1998 - "Deficient plakoglobin expression on the primary tumor was significantly correlated to a shortened disease-free and overall survival in patients with adenocarcinomas, pT1-2 tumors, or negative lymph nodes (pN0). " 01/01/2007 - "p120 and gamma-catenin displayed membranous staining in 100% of tubulolobular and tubular carcinomas and cytoplasmic staining in 100% of lobular carcinomas. " 02/01/2006 - "Expression of CD44v6 and nuclear beta- and gamma-catenin were detected only in borderline tumors and adenocarcinomas. "
3.	Carcinoma (Carcinomatosis) 06/20/2005 - "In this study, we directly addressed the question of the role of plakoglobin in bladder tumorigenesis following restoration, or knockdown of expression in bladder carcinoma cell lines. " 10/01/2004 - "In this study, we investigated the clinical relevance of alpha-, beta-, and gamma-catenin immunoexpression in 104 cases of primary ovarian carcinoma with respect to clinicopathological features and as predictors of disease recurrence and prognosis. " 01/01/2013 - "Finally, plakoglobin expression resulted in decreased in vitro proliferation, migration and invasion in different carcinoma cell lines. " 01/01/2013 - "These results were confirmed following plakoglobin expression in the very low plakoglobin expressing and invasive mammary carcinoma cell line MDA-MB-231 cells (MDA-231-PG). " 01/01/2013 - "Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2013 - "Together with the results of our previous studies, the data suggests that plakoglobin suppresses tumorigenesis and metastasis through the regulation of genes involved in these processes. " 08/28/2014 - "In mouse models, knockdown of plakoglobin abrogates CTC cluster formation and suppresses lung metastases. " 01/01/2012 - "In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis." 01/01/2012 - "The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. " 01/01/2012 - "Plakoglobin: role in tumorigenesis and metastasis."
5.	Breast Neoplasms (Breast Cancer) 06/01/2015 - "Here, we aim to summarize the studies on the roles of plakoglobin and evaluate the association of plakoglobin and breast cancer survival. " 06/01/2012 - "This study thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly disseminating breast cancer." 07/01/2000 - "In this study, we screened 24 human breast cancer cell lines and three immortalized human breast epithelial cell lines for alterations in beta- and gamma-catenin and APC by western blotting, protein truncation assay and DNA sequence analysis. " 06/01/2015 - "Plakoglobin may be a potential prognostic biomarker that can be exploited to develop as a therapeutic target for breast cancer. " 06/01/2015 - "Finally, based on an open-access database, the association between plakoglobin and breast cancer survival was investigated using univariate and multivariate survival analyses. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Proteins (Proteins, Gene)
3.	beta Catenin
4.	alpha Catenin (alpha E-Catenin)
5.	Desmoplakins (Desmoplakin)
6.	Messenger RNA (mRNA)
7.	Vimentin
8.	Cyclin D2
9.	Paraffin
10.	delta catenin

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Transplants (Transplant)
3.	Cystectomy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Therapeutics