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alpha Catenin (alpha E-Catenin)

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A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

Also Known As:

alpha E-Catenin; CAP102 Protein; Cadherin-Associated Protein 102 kDa; alpha-1 Catenin; alpha-Catenin; alpha-Catulin; alphaE Catenin; Cadherin Associated Protein 102 kDa; Catenin, alpha; Catenin, alpha-1; Catenin, alphaE; E-Catenin, alpha; alpha 1 Catenin; alpha Catulin; alpha E Catenin

Networked: 279 relevant articles (2 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Cytoskeletal Proteins: 557
    - Catenins: 248
      - alpha Catenin: 279
        mouse Ctnna2 protein: 2
        Drosophila alpha-Cat protein
        human CTNNA1 protein
        human CTNNA2 protein
        human CTNNA3 protein
        human CTNNAL1 protein
        mouse Catna1 protein

Experts

1.	Kosma, V M: 4 articles (09/2002 - 11/2000)
2.	Ozawa, Masayuki: 3 articles (08/2008 - 04/2004)
3.	Bruyneel, Erik: 3 articles (02/2008 - 03/2002)
4.	van Bokhoven, A: 3 articles (09/2007 - 01/2000)
5.	van Roy, Frans: 3 articles (03/2007 - 04/2002)
6.	Tsuneyoshi, M: 3 articles (12/2001 - 11/2000)
7.	Mareel, M: 3 articles (09/2001 - 03/2000)
8.	Saito, T: 3 articles (11/2000 - 01/2000)
9.	Dziki, Adam: 2 articles (11/2012 - 01/2009)
10.	Ferenc, Tomasz: 2 articles (11/2012 - 01/2009)

Related Diseases

1.	Adenoma (Adenomas) 01/01/2010 - "Hepatic adenomas with alpha-catenin mutations have a significantly greater risk for malignant transformation in comparison with the other two subgroups. " 11/13/2007 - "Alpha-catenin is essential in intestinal adenoma formation." 09/01/2002 - "alpha-catenin was not detected in the nuclei in any of the sporadic or familial adenomas. " 11/13/2007 - "These data strongly indicate that simultaneous inactivation of alpha-catenin and Apc during tumor initiation suppresses adenoma formation in line19-Apc(580D/+), suggesting that alpha-catenin plays an essential role in the initiation of intestinal adenomas. " 06/01/1998 - "Normal mucosa, as well as 8/10 of the colon adenomas, showed strong membranous alpha-catenin expression. "
2.	Rupture 06/03/2008 - "The immunoblot analysis confirmed a significant reduction in remote areas, and complete absence of alphaE-catenin in infarct areas from infarct rupture patients. " 06/03/2008 - "The data show a reduced expression and defective localization of alphaE-catenin in the intercalated disc region in patients dying of infarct rupture. " 06/03/2008 - "Three-fourths of the heterozygous alphaE-catenin C-terminal truncated mice died of infarct rupture, compared with one-fourth of the wild-type littermates. " 06/03/2008 - "No alphaE-catenin was detected in 70% of remote samples of infarct rupture hearts compared with 20% in control MI by immunohistochemistry. " 06/03/2008 - "In addition, infarct rupture was studied in transgenic mice heterozygous for alphaE-catenin C-terminal deficiency, mimicking the situation in human infarct rupture patients. "
3.	Neoplasms (Cancer) 11/13/2007 - "A mouse model used in this study focused on the early stage of tumor initiation and clearly indicated an essential role for alpha-catenin. " 01/01/2015 - "Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression." 12/01/2010 - "Micrometastasis was found more frequently in a pathological T2 status and in the tumors with a negative expression of alpha-catenin. " 07/01/2010 - "As anticipated, loss of alpha-catenin protein expression was associated with the lobular subtype in primary breast cancers. " 01/01/2010 - "The expression of alpha-catenin in the main mass of tumor was also associated with histological differentiation and Lauren's classification. "
4.	Colorectal Neoplasms (Colorectal Cancer) 10/01/2009 - "A subpopulation of alpha-catenin-negative cells within the DLD-1 colorectal carcinoma cell line causes it to display a heterogeneous morphological makeup, thus providing an excellent model system in which to investigate the role of alpha-catenin in tumorigenesis. " 08/21/2008 - "To investigate the changing pattern of alpha-catenin expression and its relationship to clinical and pathological features of colorectal cancer (CRC) patients. " 08/21/2008 - "Up-regulation of alpha-catenin is associated with increased lymph node involvement in colorectal cancer." 09/01/2002 - "alpha-catenin can localize to the nuclei of colorectal tumor cells, and this may be related to lack of perception of connection to adjacent cells." 09/01/2002 - "Nuclear localization of alpha-catenin was detected in the colorectal carcinoma cell lines when the cells were dispersed rather than confluent. "
5.	Carcinoma (Carcinomatosis) 07/01/2006 - "We confirm that high-risk p53, p53 mutation, and alpha-catenin immunohistochemistry do have an additional prognostic value in primary bladder carcinoma. " 07/01/2006 - "The predictive value of p53, p27(kip1), and alpha-catenin for progression in superficial bladder carcinoma." 05/01/2006 - "Expression of the truncated mutant in the alpha-catenin deficient colon carcinoma cell line, Clone A, could not restore an adhesive phenotype when compared. " 12/01/2005 - "We transfected an alpha-catenin-deficient colon carcinoma line, which cannot organize desmosomes, with a series of alpha-catenin mutant constructs. " 12/01/2005 - "Loss of alpha-catenin expression in carcinoma of the floor of the mouth correlated significantly with poor prognosis (P=0.05). "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	beta Catenin
3.	gamma Catenin (Plakoglobin)
4.	Proteins (Proteins, Gene)
5.	alpha Catenin (alpha E-Catenin)
6.	Catenins
7.	delta catenin
8.	Messenger RNA (mRNA)
9.	Antibodies
10.	Vimentin

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Drug Therapy (Chemotherapy)